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Could a malaria drug treat cervical Pre-Cancer?

NCT ID NCT04098744

Recruiting now Disease control Sponsor: Frantz Viral Therapeutics, LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase II trial tests whether artesunate, a drug originally used for malaria, can reverse cervical pre-cancer (CIN2/3) when given as a vaginal insert. About 78 women with high-grade cervical lesions will receive either artesunate or a placebo for three 5-day cycles. The main goal is to see if the lesions shrink or disappear by week 17, potentially offering a non-surgical treatment option.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
artesunate vaginal insert
What this could lead to
If it works, this could provide a non-surgical treatment for cervical pre-cancer, potentially reducing the need for procedures like LEEP.
What could go wrong
This is a small, early-phase trial with only 78 participants. It may not show enough benefit over placebo, and the treatment is still experimental with unknown long-term effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cervical intraepithelial neoplasia cervical intraepithelial neoplasia grade 2/3 dysplasia of cervix human papilloma virus infection precancerous condition

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CERVICAL DYSPLASIA CIN 2/3 HPV INFECTION HPV RELATED DISEASE PRE-CANCEROUS DYSPLASIA

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Cleveland Clinic Fairview Hospital

    RECRUITING

    Cleveland, Ohio, 44111, United States

  • Cleveland Clinic Foundation

    RECRUITING

    Cleveland, Ohio, 44195, United States

  • Florida Gynecologic Oncology

    RECRUITING

    Fort Myers, Florida, 33905, United States

  • Hillcrest Hospital

    RECRUITING

    Mayfield Heights, Ohio, 44124, United States

  • The Harris Health System (L.B.J Hospital)

    RECRUITING

    Houston, Texas, 77026, United States

  • University of Michigan

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

  • University of Texas, M.D. Anderson

    RECRUITING

    Houston, Texas, 77030, United States

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