HPV INFECTION

This study tests an experimental vaccine that targets 11 types of HPV, the virus that causes cervical cancer. About 13,500 Chinese women aged 18-45 will receive either the vaccine or a placebo over 6 months. The goal is to see if the vaccine prevents serious cervical cell changes…

This study looks at whether giving girls aged 9-14 a different HPV vaccine for their second dose (switching from a 2-valent to a 9-valent vaccine) is safe and produces a strong immune response. About 400 girls who have never received an HPV vaccine will take part. The goal is to …

This study tests whether two doses of the HPV vaccine work as well as three doses for women aged 27 to 45. About 618 women will be randomly assigned to receive either two or three shots, and their immune response will be checked over 12 months. The goal is to see if a shorter vac…

This study tests a new 15-valent HPV vaccine to see if it is safe and triggers a strong immune response. It involves 330 healthy Chinese volunteers aged 9 to 45. Participants receive three doses of the vaccine or a placebo, and researchers monitor side effects and antibody levels…

This study tests whether a vaginal insert containing artesunate, a drug originally used for malaria, can help reverse high-grade cervical pre-cancer (CIN2/3) caused by HPV. About 78 women will receive either the drug or a placebo over three 5-day cycles. The main goal is to see i…

This study tests an experimental vaginal suppository called Dysplasix in women with high-risk HPV and mild cervical cell changes (ASC-US or LSIL). The goal is to see if the treatment can clear the virus and reverse the abnormal cells. Forty-five women will receive either the acti…

This study tests whether a non-invasive physical plasma treatment can clear HPV infections from the cervix. About 50 adults with HPV will receive the treatment, and researchers will check if the virus is gone afterward. The goal is to find a new way to prevent cervical cancer cau…

This study looks at whether giving women a simple at-home kit to test for HPV (the virus that can cause cervical cancer) makes it easier for those who are overdue for screening to get tested. About 100 women aged 25-65 who haven't had a Pap smear in 3 years will receive a self-co…

This study is testing whether a special menstrual pad (Q-Pad) can accurately detect high-risk HPV from period blood collected at home. About 450 people who need a colposcopy after an abnormal Pap or HPV test will use the pad during their period and mail it to a lab. Researchers w…

This study explores whether women from underserved communities can accurately collect their own samples to test for HPV, the virus that can cause cervical cancer. Researchers will compare results from two different self-collection kits to standard Pap smears. The goal is to make …

This study is testing a handheld, AI-powered colposcope (called Pocket CARE) to see if it can accurately detect cervical pre-cancer in women who have tested positive for HPV. About 1,054 women in Kenya will use the device during a pelvic exam. The goal is to improve screening and…

This study aims to see if a self-administered swab test for HPV (a virus linked to anal cancer) works as well as a test done by a healthcare professional. It focuses on people living with HIV, who have a higher risk of anal cancer. Researchers want to know if the self-test is acc…

This study tests whether a daily supplement containing EGCG (from green tea), folic acid, and vitamin B12 can help women clear a high-risk HPV infection from the cervix. About 100 women with a positive HPV test but no serious cell changes will take the supplement for several mont…

This study looks at how often men with inflammatory bowel disease (IBD) have HPV infection in their mouth and anal area. Researchers will collect samples from 384 men to find out how common the virus is and what factors increase the risk. The goal is to better understand HPV in t…

This study follows up with 100 people who were part of the ANRS IPERGAY trial to see if certain HPV molecular signatures are linked to high-grade anal lesions or cancer 10 years later. Researchers will use high-resolution anoscopy to check for abnormalities. The goal is to better…

This study tests a faster way to screen and treat cervical cancer in women living with HIV in the Dominican Republic. It compares same-day HPV testing and treatment to the usual care. The goal is to see if more women complete the full screening process, which could save lives.

This study follows 250 women living with HIV in Zimbabwe who have been treated for cervical pre-cancer. Researchers want to understand why some women's pre-cancer returns after treatment and how to better monitor them. Participants will have regular check-ups and tests over two y…

This study compares two ways to offer cervical cancer screening to women living with HIV: standard clinic-based screening versus also providing HPV self-collection kits through community health workers. About 2,900 women will take part to see if the community approach increases s…