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Could a vaginal suppository clear High-Risk HPV?

NCT ID NCT07572396

Recruiting now Disease control Sponsor: Amplexd Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether a vaginal suppository called Dysplasix can help women clear high-risk human papillomavirus (HPV) and reverse low-grade cervical abnormalities. About 45 women with HPV and mild cervical changes will use the suppository or a placebo for 19 days. Researchers will check if the lesions shrink and if the virus clears, while monitoring safety.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Epigallocatechin gallate and quinine sulfate vaginal suppository
What this could lead to
If it works, this could offer a non-surgical treatment option to clear high-risk HPV and reverse early cervical changes, potentially reducing the need for procedures.
What could go wrong
This is a small, early-phase trial with only 45 participants, so results may not apply to everyone. The treatment may not work better than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Atypical Squamous Cells of the Cervix cervical intraepithelial neoplasia cervical squamous intraepithelial neoplasia dysplasia of cervix human papilloma virus infection squamous cell intraepithelial neoplasia Squamous Intraepithelial Lesions

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASC-US CERVICAL ABNORMALITIES HIGH-RISK HPV (ANY STRAIN) HPV INFECTION LSIL, LOW GRADE SQUAMOUS INTRAEPITHELIAL LESION UTERINE CERVICAL DYSPLASIA

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Prince of Wales Hospital

    RECRUITING

    Shatin, New Territories, Hong Kong

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

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