New vaccine combo aims to clear persistent HPV infection
NCT ID NCT03913117
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial tests two vaccines designed to help the immune system fight HPV16, a virus linked to cervical cancer. The study includes 30 women with persistent HPV16 infection and mild cervical cell changes (ASC-US or LSIL). Participants receive a DNA vaccine followed by a protein vaccine boost, with the main goals being safety and finding the right dose.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
pNGVL4aCRTE6E7L2 DNA vaccine and TA-CIN protein vaccine
What this could lead to
If successful, this could lead to a therapeutic vaccine that helps the immune system clear persistent HPV16 infection, potentially preventing progression to cervical cancer.
What could go wrong
This is a very early Phase 1 trial with only 30 participants, focused on safety and dosing. The vaccines may not produce a strong enough immune response to clear the virus, and side effects are unknown.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Johns Hopkins University
RECRUITINGBaltimore, Maryland, 21231, United States
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UAB | The University of Alabama at Birmingham
RECRUITINGBirmingham, Alabama, 35249, United States
Contact Email: •••••@•••••