DNA vaccine aims to train immune system against HPV-Linked cervical lesions
NCT ID NCT04131413
First seen Jul 02, 2026 · Last updated Jul 02, 2026
Summary
This phase 1 trial tests a DNA vaccine designed to target HPV16, a virus that can cause high-grade cervical lesions (CIN2/3). The vaccine is given by injection into the muscle followed by a mild electrical pulse to help cells take up the DNA. The study includes both HIV-negative and HIV-positive women with confirmed HPV16-positive lesions. The main goal is to see if the vaccine is safe and tolerable at different doses.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
pNGVL4aCRTE6E7L2 HPV DNA vaccine
What this could lead to
If successful, this vaccine could offer a non-surgical treatment option for precancerous cervical lesions caused by HPV16.
What could go wrong
This is an early phase 1 trial with a small number of participants, so safety and effectiveness are not yet established. The vaccine may not work or could cause side effects.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Johns Hopkins University
RECRUITINGBaltimore, Maryland, 21231, United States
Contact Email: •••••@•••••
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University of Alabama at Birmingham
RECRUITINGBirmingham, Alabama, 35233, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Email: •••••@•••••
Contact