Sidney Kimmel Comprehensive Cancer Center At Johns Hopkins

This study is testing a new vaccine called PVX7 in 32 women with advanced cervical cancer who have finished their main treatment (surgery, radiation, or chemo). The goal is to see if the vaccine is safe and can boost the body's immune response against HPV, the virus that causes c…

This early-stage study tests a vaccine designed to train the immune system to attack cells with a mutated KRAS gene, which is common in pancreatic cancer. The vaccine is given to people at high risk due to family history or pancreatic cysts. The main goals are to see if the vacci…

This phase 2 trial tests a DNA vaccine called pBI-11 in 48 women with persistent HPV16 or HPV18 cervical infection. The vaccine is designed to boost the immune system to clear the virus. Participants receive the vaccine or a placebo via injection with a special device. The study …

This phase 2 trial will test whether adding immunotherapy drugs (cemiplimab alone or with fianlimab or REGN7075) to standard chemotherapy (capecitabine and oxaliplatin) can completely eliminate tumors in patients with locally advanced rectal cancer before surgery. The study plans…

This study tests a new way to treat thyroid cancer that has returned or spread. It combines two types of radiation—external beam radiation and radioactive iodine—to deliver a stronger dose to tumors. The goal is to see if this combination is safe and can give a higher radiation d…

This Phase II trial is testing whether adding the immunotherapy drug atezolizumab to standard chemotherapy (platinum and etoposide) before bladder removal surgery can completely eliminate the cancer in people with a rare, aggressive form of bladder cancer called small cell neuroe…

This phase 2 trial tests a two-step treatment for men with metastatic prostate cancer that no longer responds to standard hormone therapy. First, patients receive a combination of testosterone and an experimental drug called ZEN-3694, followed by a mix of enzalutamide and ZEN-369…

This early-phase study tests a personalized peptide vaccine (mBTCvax) combined with two immunotherapy drugs (durvalumab and tremelimumab) in 25 adults with advanced biliary tract cancer. The goal is to see if the combination is safe and can boost the immune system's ability to ta…

This study tests whether immunotherapy drugs (cemiplimab alone or with fianlimab) can shrink or eliminate tumors in older patients (70+) or those unfit for surgery with a specific genetic type of colorectal cancer (MSI-H). The goal is to avoid surgery if the cancer disappears com…

This phase 2 trial tests a new drug called NC410 combined with standard chemotherapy (FOLFIRINOX) and immunotherapy drugs (nivolumab with or without ipilimumab) in 20 people with metastatic pancreatic cancer who have not had prior treatment. The main goal is to check safety and i…

This study tests whether a special MRI scan, called amide proton transfer (APT) imaging, can help doctors target the most aggressive parts of brain tumors during radiotherapy. Twenty adults with glioblastoma or grade 4 astrocytoma will receive either standard radiotherapy or a ne…

This phase 2 trial tests whether the immunotherapy drug nivolumab, alone or combined with relatlimab or ipilimumab, can shrink tumors in people with advanced basal cell carcinoma that cannot be removed by surgery or has spread. About 57 participants will receive one of the drug c…

This pilot study is testing a precise form of radiation called proton SBRT for people with cancer that has spread to the spine and cannot be treated effectively with standard photon radiation. The study will enroll 12 participants and aims to see if the treatment can be delivered…

This study tests giving chemotherapy and immunotherapy before standard surgery for head and neck cancer. The goal is to shrink tumors enough so that surgeons can perform less extensive, function-preserving operations, reducing damage to swallowing, speech, and vision. The trial e…

This study tests whether giving targeted radiation to cancer that has spread (metastasized) can help children, teens, and young adults with sarcoma live longer. About 70 participants with soft tissue or bone sarcoma will receive consolidative radiation therapy to their metastatic…

This study is testing whether a shorter course of proton therapy (just five treatments) before surgery for soft tissue sarcoma is safe and effective. Researchers will track wound healing, side effects, and quality of life in 40 adult patients over two years. The goal is to see if…

This trial tests whether a lower dose of total body irradiation (200 cGy) before a bone marrow transplant works as well as a standard higher dose (400 cGy) for people with acute leukemia. The goal is to see which dose leads to fewer severe side effects like graft-versus-host dise…

This study is for men with a type of advanced prostate cancer that no longer responds to standard hormone therapy. It compares two treatments: taking the drug enzalutamide alone versus taking it along with high-dose testosterone in cycles. The goal is to see if the combination ca…

This study tests a precise type of radiation called proton beam therapy for people with kidney cancer who cannot have surgery. The goal is to see how well it controls the tumor and how it affects kidney function. About 20 adults with early-stage kidney cancer will receive a few t…

This study tests a daily pill called olaparib in 20 adults with advanced kidney cancer that has spread. To join, your cancer must have a specific gene change (like BAP-1 or BRCA) and you must have already tried at least one other treatment. The goal is to see if olaparib can shri…

This early-phase study tests a vaccine that targets specific KRAS mutations in advanced non-small cell lung cancer. About 12 participants will receive the vaccine alongside standard chemotherapy and two immunotherapy drugs (nivolumab and ipilimumab). The main goal is to check saf…

This early-phase trial tests whether adding the drug momelotinib to standard azacitidine treatment can better control rare blood cancers like chronic myelomonocytic leukemia and chronic neutrophilic leukemia. About 18 adults will take momelotinib pills daily plus azacitidine inje…

This study tests a new way to treat metastatic prostate cancer that has stopped responding to standard hormone therapy. Researchers will give men high doses of testosterone followed by a drug called darolutamide, repeating this cycle to see if it keeps the cancer from growing lon…

This study is testing a bone marrow transplant from a half-matched family donor for people with high-risk solid tumors that have come back or not responded to treatment. Participants receive mild chemotherapy and radiation before the transplant, along with drugs to prevent reject…

This phase 2 trial is testing whether giving two drugs—pembrolizumab (Keytruda) and IO102-103—before surgery is safe and effective for people with head and neck cancer. The study will enroll 30 adults whose cancer can be surgically removed. Researchers will watch for side effects…

This phase II trial is testing whether giving the immunotherapy drug cemiplimab (sometimes with chemotherapy) before standard treatment can shrink tumors enough to allow less intense local therapy, such as reduced radiation or surgery. The goal is to maintain high cure rates whil…

This is a special, single-patient program for someone with prostate cancer who has run out of standard options. The treatment, called X-PACT, combines a drug called methoxsalen with a phosphor device and targeted X-ray energy to attack the tumor directly. The goal is to control t…

This study tests whether adding dexamethasone or metronidazole to standard therapy can restore sensitivity to abiraterone in men with metastatic prostate cancer that has stopped responding. About 58 men whose cancer progressed on abiraterone will receive either dexamethasone or d…

This early-phase study tests a new way to deliver radiation implants (brachytherapy) for men with localized prostate cancer. By using advanced imaging (PET/CT and ultrasound) to map only the aggressive tumor areas, doctors hope to target the cancer while leaving healthy tissue un…

This study tests whether combining a glutamine-blocking drug (DRP-104) with an immunotherapy (durvalumab) can shrink or control advanced fibrolamellar carcinoma, a rare liver cancer. About 27 people aged 12 and older whose cancer has worsened despite prior treatment will receive …

This study tests whether adding a special hormone therapy (bipolar androgen therapy) to a targeted radiation drug (radium-223) can slow the growth of prostate cancer that has spread to bones and stopped responding to standard hormone treatments. About 47 men with this advanced ca…

This study tests whether the drug nivolumab can be safely given after a half-matched bone marrow transplant to help prevent sarcomas from coming back. It includes children and young adults up to age 50 who have already had the transplant and are at high risk of relapse. Researche…

This Phase 2 trial tests a sequence of three drugs—DFMO, high-dose testosterone, and enzalutamide—in 50 men with metastatic castration-resistant prostate cancer that has progressed on standard therapy. The goal is to see if this combination can lower PSA levels and delay cancer g…

This early-stage trial is testing whether combining a chemotherapy wafer placed in the brain during surgery with an immunotherapy drug and standard radiation (with or without another chemo pill) is safe and feasible for people with newly-diagnosed glioblastoma. About 50 adults wh…

This phase II trial tests two drugs—enfortumab vedotin and pembrolizumab—in 20 people with high-grade upper tract urothelial cancer who cannot or choose not to have surgery to remove the kidney and ureter. The goal is to see if the combination can control the cancer and preserve …

This early-stage study tests a cancer vaccine that targets a common mutated protein (KRAS) combined with two immunotherapy drugs (balstilimab and botensilimab) in people with advanced colorectal or pancreatic cancer that has spread. The goal is to see if the combination can shrin…

This study tests whether using MRI scans to guide brachytherapy (a type of internal radiation) can better target tumors in gynecologic cancers like cervical, uterine, vaginal, vulvar, and bladder cancers. The goal is to see if MRI guidance reduces radiation exposure to nearby hea…

This study tests whether giving a mix of two chemotherapy drugs (gemcitabine and cisplatin) plus an immunotherapy drug (pembrolizumab) before and after surgery is safe and helps shrink tumors in people with biliary tract cancer. About 27 adults with resectable cancer will take pa…

This early-phase trial tests a peptide vaccine designed to target a specific protein found in fibrolamellar carcinoma (FLC), a rare liver cancer. The vaccine is combined with two immunotherapy drugs (nivolumab and ipilimumab) to boost the immune system's attack on cancer cells. T…

This study tests two different cancer vaccines (GVAX and a KRAS peptide vaccine) given with two immunotherapy drugs (balstilimab and AGEN2373) in people with pancreatic cancer that can be surgically removed. The goal is to find the safest dose and see if the combination helps the…

This phase 2 trial is testing a stem cell transplant using a milder chemotherapy regimen to treat people with severe immune deficiencies and inherited bone marrow failure. The goal is to see if donor cells can safely take over and rebuild a healthy immune system. Up to 27 partici…

This study tests whether giving the drug enoblituzumab for 12 weeks before prostate removal surgery can help prevent cancer from coming back in men with high-risk localized prostate cancer. About 219 men will be randomly assigned to receive either the drug or standard care. The m…

This study tests if two drugs, senaparib and temozolomide, can shrink tumors in people with a certain type of ovarian cancer that has an ARID1A gene change. About 18 adults with recurrent or persistent clear cell or endometrioid ovarian, fallopian tube, or primary peritoneal canc…

This study tests whether a 12-week exercise program can reduce the number of cancer cells in the blood of men with advanced prostate cancer. Twenty men who are already on hormone therapy will participate. The goal is to see if exercise can help control the disease, not cure it.

This early-phase study tests whether Darzalex Faspro can safely lower donor-specific antibodies (DSAs) in 8 adults with blood cancers or bone marrow failure who are at high risk of rejecting a stem cell transplant. The goal is to reduce DSA levels enough to allow the transplant t…

This pilot study tests whether adjusting chemotherapy based on early PET scan results can improve outcomes for people with stage 2 or 3 triple negative breast cancer. Participants receive four cycles of chemotherapy plus the immunotherapy drug pembrolizumab. A PET scan after the …

This pilot study is testing a peptide vaccine designed to prevent or delay resistance in people with advanced ALK-positive lung cancer who are already on targeted therapy. The vaccine targets ALK protein mutations to boost the immune system. The study will enroll 12 participants …

This early-phase trial tests a new radioactive imaging agent, [18F]DK222, in 6 people with non-small cell lung cancer or urothelial cancer. The agent is designed to attach to PD-L1, a protein that helps cancer hide from the immune system. Researchers want to see if the agent is s…

This study looks at whether virtual music therapy is practical and helpful for people recently diagnosed with glioblastoma, a serious brain cancer. Thirty-five participants will either join live music therapy sessions with a board-certified therapist or listen to curated playlist…

This registry collects detailed information from cancer patients treated with proton radiation therapy. Researchers will track treatment plans, side effects, and quality of life over 15 years. The goal is to learn which patients benefit most from this precise form of radiation an…

This study explores whether a 7-day water-only fast or ketone supplements are safe and doable for men with prostate cancer. The idea is that fasting may change the body's metabolism and boost immune cells to better attack cancer. Researchers will track side effects and how many p…

This study explores whether planning radiation therapy to avoid key brain regions can reduce thinking and learning problems in children with brain or head and neck tumors. Participants include children receiving radiation, survivors who completed radiation at least two years ago,…

This study aims to screen 450 early-stage breast cancer survivors for prediabetes, diabetes, high cholesterol, and heart disease risk. Participants complete surveys and provide lab results, and those with risk factors are directed to community resources. The goal is to catch and …

This study compares two levels of patient navigation—high-intensity versus low-intensity—to see which helps more people with prostate or kidney cancer enroll in clinical trials. About 90 participants will be randomly assigned to receive either extra support from a patient navigat…

This early-phase trial is looking at whether tumor DNA found in blood and spinal fluid can help monitor how well treatment is working in people with a specific type of brain tumor (BRAF-mutant glioma). About 24 participants whose tumors have not responded to prior therapies will …

This study looks at how SPECT imaging can help doctors measure the amount of radiation reaching healthy organs during certain cancer treatments. About 80 adults with advanced prostate or other cancers will get extra SPECT scans before and after their standard radiation therapy. T…

This study aims to increase the use of next-generation sequencing (NGS) testing in men with metastatic prostate cancer at Johns Hopkins. Researchers will test ways to overcome barriers for both doctors and patients. About 256 men newly diagnosed with metastatic prostate cancer wi…

This study collects blood, tumor, and other tissue samples from up to 1,250 people with head and neck, lung, or gastrointestinal cancers. Researchers want to understand how the immune system changes during cancer treatments, especially immunotherapies. Participants donate samples…

This study enrolls 30 adults with breast cancer that has spread to the lining of the brain or spinal cord (leptomeningeal disease). Researchers will collect tissue and fluid samples to learn more about this aggressive condition. The goal is to provide faster test results and trea…

This study explores whether a liquid biopsy (a blood test) can find genetic changes in tumors to guide personalized cancer treatment. Researchers will enroll 150 adults with solid tumors to see if these tests can help doctors pick better therapies and monitor response. The goal i…

This study is creating a registry for children and young adults (up to age 26) receiving proton or photon radiation therapy for sarcoma or brain tumors. Researchers will collect data on survival, side effects, and quality of life over many years to better understand long-term out…

This study looks at whether changes in tumor DNA found in the blood and special imaging scans can predict how well chordoma tumors respond to radiation therapy given before surgery. About 40 adults with chordoma of the spine, skull base, or sacrum will receive proton therapy or s…