Sidney Kimmel Comprehensive Cancer Center At Johns Hopkins

This study tests a cancer peptide vaccine designed to prevent or delay resistance in people with advanced ALK-positive lung cancer who are already on targeted therapy. About 12 participants will receive the vaccine alongside their current medication. The main goals are to check s…

This early-stage study tests a vaccine designed to train the immune system to attack cells with a specific mutation (mutant KRAS) that can lead to pancreatic cancer. The vaccine is given to people who are at high risk due to family history or pancreatic abnormalities. The main go…

This early-stage trial tests a new vaccine called PVX7 in 32 women with advanced cervical cancer who have finished their main treatment (surgery, radiation, or chemo). The goal is to see if the vaccine is safe and can boost the body's immune response against HPV, the virus that c…

This study tests a precise proton radiation therapy for people with spinal tumors that cannot be treated with standard photon radiation. The goal is to see if this approach is feasible and safe. About 12 participants will receive the treatment, and researchers will monitor for si…

This early-phase study tests a vaccine that targets specific KRAS mutations in advanced non-small cell lung cancer. About 12 participants will receive the vaccine alongside standard chemotherapy and immunotherapy drugs (nivolumab and ipilimumab). The main goal is to check safety …

This study tests if a short course of proton therapy (5 sessions) before surgery for soft tissue sarcoma in the arms, legs, or trunk is safe and effective. About 40 adults will receive the therapy and then have standard surgery. Researchers will track wound healing problems and q…

This study tests whether giving the drug enoblituzumab for 12 weeks before prostate removal surgery can help prevent prostate cancer from coming back in men with high-risk localized disease. About 219 men will be randomly assigned to receive either the drug or standard care. The …

This study tests whether early PET scans can help doctors adjust chemotherapy and immunotherapy for people with stage 2 or 3 triple negative breast cancer. About 30 participants will receive four cycles of chemo plus the drug pembrolizumab. A PET scan after the first cycle will s…

This study is for children, teens, and young adults up to age 39 with sarcoma that has spread to a few other places in the body. Researchers want to see if giving extra radiation to those spread spots, along with usual treatment, can help patients live longer without the cancer g…

This study tests whether Darzalex Faspro can safely lower donor-specific antibodies (DSAs) in adults with blood cancers who are at high risk of rejecting a stem cell transplant. Participants receive the drug before standard transplant preparation to reduce DSA levels enough to al…

This study tests a daily pill called olaparib in people with advanced kidney cancer that has certain gene mutations (like BAP-1 or BRCA). The goal is to see if the drug can shrink tumors or keep them stable for at least six months. About 20 adults who have already tried other tre…

This study tests whether two immunotherapy drugs, cemiplimab and fianlimab, can eliminate tumors in older patients (70+) or those unfit for surgery with a specific genetic type of colorectal cancer (MSI-H). Participants receive the drugs and are monitored with scans and scopes to…

This study tests a stem cell transplant method for people with serious immune disorders or bone marrow failure. The goal is to see if a gentler pre-transplant treatment, followed by a drug to prevent rejection, can help donor cells take over and restore healthy blood and immune f…

This study tests a new drug (NC410) combined with standard chemotherapy (FOLFIRINOX) and two immunotherapy drugs (nivolumab with or without ipilimumab) in people with metastatic pancreatic cancer who have not had prior treatment. The main goal is to check safety and find any unex…

This study tests two different cancer vaccines (GVAX and mKRASvax) combined with two immunotherapy drugs (balstilimab and AGEN2373) in people with pancreatic cancer that can be surgically removed. The goal is to find the safest dose and see if the treatment helps the immune syste…

This study is for people with untreated metastatic pancreatic cancer that has spread to other parts of the body. Participants first receive a low-dose combination of five chemotherapy drugs, then continue with two maintenance medications (olaparib and pembrolizumab) to help keep …

This is a single-patient program for someone with advanced prostate cancer who has run out of standard treatments. The experimental therapy, X-PACT, combines a drug called methoxsalen with a special device that activates it using X-rays, injected directly into the tumor. The goal…

This study tests a new treatment approach for men with metastatic prostate cancer that has stopped responding to standard hormone therapy. It alternates high-dose testosterone with a drug called darolutamide to see if this cycling can keep the cancer under control longer. About 6…

This early-stage study tests a personalized cancer vaccine (mBTCvax) combined with two immunotherapy drugs (durvalumab and tremelimumab) in 25 adults with advanced biliary tract cancer. The goal is to see if the combination is safe and can strengthen the body's immune response ag…

This study tests whether combining two drugs, senaparib and temozolomide, can shrink tumors in people with a certain type of ovarian cancer linked to an ARID1A gene change. About 18 adults with recurrent or persistent clear cell or endometrioid ovarian, fallopian tube, or primary…

This study tests a combination of two cancer drugs, enfortumab vedotin and pembrolizumab, in 20 people with high-grade upper tract urothelial cancer (a rare cancer of the kidney and ureter). Participants are those who cannot or choose not to have standard surgery to remove the ki…

This study tests adding the drug momelotinib to standard treatment for people with certain rare blood cancers (MDS/MPN and chronic neutrophilic leukemia). The goal is to better control the disease, improve symptoms, and help more patients become eligible for a transplant. About 1…

This study tests a bone marrow transplant from a partially matched family donor for people with high-risk solid tumors that have not responded to standard treatments. The goal is to see if a milder chemotherapy regimen and shorter use of immune-suppressing drugs can make the tran…

This study tests whether giving high-dose testosterone followed by the drug enzalutamide works better than enzalutamide alone for men with a type of advanced prostate cancer that no longer responds to standard hormone therapy. About 150 men without pain from their cancer will tak…

This early-stage trial tests whether adding an immunotherapy drug (retifanlimab) to standard treatment (carmustine wafers, radiation, and possibly temozolomide) is safe and helps people with newly diagnosed glioblastoma, a fast-growing brain cancer. About 50 adults who have alrea…

This study tests a sequence of three drugs—DFMO, high-dose testosterone, and enzalutamide—in 50 men with metastatic prostate cancer that has stopped responding to standard hormone therapy. The goal is to see if this approach can lower PSA levels and delay cancer growth. Participa…

This study tests whether the drug nivolumab can be safely given after a half-matched bone marrow transplant to help prevent sarcomas from coming back. It includes children and young adults (ages 1 to 50) who have recently had this transplant and are at high risk of relapse. Resea…

This study tests whether giving two drugs (pembrolizumab and IO102-103) before surgery is safe and effective for people with head and neck cancer that can be removed. About 30 adults with newly diagnosed or returning cancer will receive the drug combination, then have surgery. Re…

This study tests a more precise type of radiation therapy for men with early-stage prostate cancer. Instead of treating the whole prostate, doctors use special scans to find only the aggressive parts of the tumor and target those with radiation seeds. The goal is to control the c…

This study tests a vaccine that targets a specific protein found only in fibrolamellar carcinoma (FLC), a rare liver cancer. The vaccine is given together with two immunotherapy drugs (nivolumab and ipilimumab) to boost the immune system's attack on cancer cells. The trial includ…

This study tests two different low doses of total body irradiation (200 vs 400 cGy) given before a stem cell transplant for people with acute leukemia. The goal is to see which dose better prevents severe graft-versus-host disease, relapse, and death. About 160 participants will …

This study tests whether adding dexamethasone or metronidazole (a gut bacteria-targeting antibiotic) can make abiraterone work again in men with metastatic prostate cancer whose disease has stopped responding to the drug. About 58 men will receive one of these combinations for up…

This study tests giving chemotherapy and an immunotherapy drug before standard surgery for head and neck cancer. The goal is to shrink tumors enough so that surgeons can perform a less extensive operation, preserving speech, swallowing, and vision. The trial enrolls 75 adults wit…

This study tests a new treatment for men with a type of advanced prostate cancer that no longer responds to standard hormone therapy. The treatment combines a hormone therapy (testosterone) with a radioactive drug (radium-223) to try to slow cancer growth. About 47 men will recei…

This study tests whether combining two drugs—DRP-104 (a glutamine blocker) and durvalumab (an immunotherapy)—is safe and can shrink tumors in people with advanced fibrolamellar carcinoma, a rare liver cancer. About 27 participants aged 12 and older whose cancer has worsened despi…

This study tests whether giving immunotherapy (with or without chemo) before standard treatments can allow doctors to use less intense, gentler therapy while still curing the cancer. About 32 adults with advanced HPV-related head and neck cancer will receive the drugs first, then…

This early-stage study tests a new vaccine that targets a common cancer-driving protein (mutant KRAS) combined with two immunotherapy drugs (balstilimab and botensilimab) in people with advanced colorectal or pancreatic cancer that has not responded to standard chemotherapy. The …

This study tests whether the immune drug nivolumab, alone or combined with relatlimab or ipilimumab, can shrink tumors in people with advanced basal cell carcinoma that cannot be removed by surgery or has spread. About 57 participants will receive treatment to see how well the ca…

This study tests whether a 12-week exercise program can reduce the number of cancer cells in the blood of men with advanced prostate cancer. Twenty men on hormone therapy will participate. Researchers will measure changes in cancer cells and DNA before, during, and after the exer…

This study is for people with kidney cancer who cannot have surgery or other local treatments. It uses a precise type of radiation called proton beam therapy to target the tumor while aiming to protect the kidney. Researchers will track how well the kidney works after treatment a…

This study tests whether using MRI to guide brachytherapy (internal radiation) can better target tumors and reduce radiation exposure to nearby organs like the bladder and rectum. About 54 adults with cervical, uterine, vaginal, vulvar, or bladder cancer will receive treatment in…

This study is for people with biliary tract cancer that can be removed with surgery. Researchers are testing a combination of three drugs (gemcitabine, cisplatin, and pembrolizumab) given before and after surgery to see if it is safe and helps shrink the tumor. About 27 adults wi…

This study is testing whether giving testosterone along with an experimental drug (ZEN-3694) first, followed by a standard prostate cancer drug (enzalutamide) plus ZEN-3694, can shrink tumors in men whose prostate cancer has spread and stopped responding to standard treatments. R…

This early-phase study tests a new imaging drug called [18F]DK222 in 6 people with lung or bladder cancer. The drug is designed to attach to PD-L1, a protein that helps cancer hide from the immune system. Researchers want to see if the drug is safe, how it moves through the body,…

This study is for people with breast cancer that has spread to the lining of the brain and spinal cord, a condition called leptomeningeal disease. The goal is to collect tissue samples and health information to better understand this aggressive cancer and to see if a rapid expert…

This study looks at whether giving cancer patients more personalized help (high-intensity navigation) makes them more likely to join a clinical trial compared to standard help (low-intensity navigation). About 90 adults with prostate or kidney cancer will take part. The goal is t…

This study looks at whether tiny bits of tumor DNA found in blood and spinal fluid can help doctors monitor how well treatment is working in people with a specific type of brain tumor (BRAF-altered glioma). About 24 patients whose cancer has not responded to prior treatments will…

This study looks at how SPECT imaging can help doctors better understand where radiation therapy goes in the body and how much reaches healthy organs. Researchers will scan 80 people with advanced prostate or other cancers who are already receiving standard radiation treatments. …

This study is for 40 adults with chordoma of the spine, skull base, or sacrum who will receive radiation therapy before surgery. Researchers want to see if changes in tumor DNA in the blood and special imaging features can predict how well the tumor responds to radiation. The goa…

This study creates a registry for up to 5,000 children and young adults (up to age 26) receiving radiation therapy for brain tumors or sarcoma. Researchers will collect detailed radiation dose information and follow participants over time to understand long-term survival, side ef…

This study collects blood, tumor, and other tissue samples from up to 1,250 people with head and neck, lung, or gastrointestinal cancers. Researchers will analyze these samples to learn how different cancer treatments affect the immune system, identify who might develop side effe…

This study looks at whether a blood test (liquid biopsy) can find genetic changes in tumors to help doctors pick the best treatment for each patient. About 150 adults with solid cancers like breast, lung, or head & neck cancer will give blood samples over time. The goal is to see…

This study looks at ways to increase the number of men with metastatic prostate cancer who receive next-generation sequencing (NGS) testing. Researchers will test methods to overcome barriers for both doctors and patients. About 256 men newly seen at Johns Hopkins will take part.…