Could a testosterone boost help fight resistant prostate cancer?

NCT ID NCT04363164

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is for men with a type of advanced prostate cancer that no longer responds to standard hormone therapy. It compares two treatments: taking the drug enzalutamide alone versus taking it along with high-dose testosterone in cycles. The goal is to see if the combination can delay cancer growth better than enzalutamide alone. About 150 men will participate, and the study is currently recruiting.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

castration-resistant prostate carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Dana-Faber Cancer Institute

    RECRUITING

    Boston, Massachusetts, 02215, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Johns Hopkins University/Sidney Kimmel Cancer Center

    RECRUITING

    Baltimore, Maryland, 21287, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of California, San Diego (UCSD)

    RECRUITING

    San Diego, California, 92037, United States

    Contact

    Contact Email: •••••@•••••

  • University of Minnesota

    RECRUITING

    Minneapolis, Minnesota, 55455, United States

    Contact

    Contact Email: •••••@•••••

  • University of Nebraska Medical Center

    RECRUITING

    Omaha, Nebraska, 68198, United States

    Contact

    Contact Email: •••••@•••••

  • University of Washington/Fred Hutchinson Cancer Center

    RECRUITING

    Seattle, Washington, 98109, United States

    Contact Email: •••••@•••••

    Contact