Leukemia transplant study tests lower radiation for better outcomes

This trial tests whether a lower dose of total body irradiation (200 cGy) before a bone marrow transplant works as well as a standard higher dose (400 cGy) for people with acute leukemia. The goal is to see which dose leads to fewer severe side effects like graft-versus-host disease and better survival without relapse. About 160 participants will be randomly assigned to one of the two radiation doses as part of their transplant preparation.