ACUTE LEUKEMIA

This study is testing a stem cell transplant from a partially matched family donor for patients with hard-to-treat blood cancers like leukemia and lymphoma. Before the transplant, patients receive chemotherapy and radiation to wipe out their own bone marrow and cancer cells. The …

This study is testing if adding a precise, targeted form of radiation to the standard treatment before a stem cell transplant can kill more cancer cells in the bone marrow and lower the chance of the disease coming back. It is for adults aged 18-75 with acute leukemia or myelodys…

This is a first-in-human study to test the safety and find the right dose of a new oral drug called BY002. It is for adults with acute leukemia that has returned or not responded to standard treatments, particularly those with specific genetic changes. The main goals are to see h…

This study is testing whether changing when a key drug is given can better prevent a serious complication called graft-versus-host disease (GVHD) after a stem cell transplant for blood cancers. It will enroll about 29 adults with leukemia or related disorders who are receiving a …

This study is testing if a drug called luspatercept is safe and can help treat anemia (low red blood cells) in people who have had a stem cell transplant for acute leukemia. The main goal is to see if the drug can increase hemoglobin levels enough to reduce the need for blood tra…

This study is observing how well umbilical cord blood stem cells from unrelated donors work for patients with serious blood cancers and disorders. Researchers will track how quickly patients' blood counts recover, how often the transplant fails, and the rates of disease relapse a…

This study is testing whether removing a specific type of immune cell (called naive T cells) from a donor's stem cells before transplant can prevent chronic graft-versus-host disease in children and young adults with blood cancers. Chronic graft-versus-host disease is a serious c…

This early-stage study is testing whether combining two oral drugs, revumenib and mezigdomide, is safe and effective for people with specific types of acute leukemia that have returned or not responded to prior treatments. The trial will enroll about 52 participants aged 12 and o…

This study is testing a new oral drug called revumenib to see if it can safely help prevent certain aggressive types of leukemia from coming back after a patient has received a stem cell transplant. The trial will enroll about 27 patients, including children as young as 2, who ha…

This early-stage study is testing the safety and feasibility of using bone marrow from deceased donors for patients with various blood cancers like leukemia and lymphoma. The goal is to see if this type of transplant can help patients when a living donor isn't available. Research…

This study is testing a new method to help patients recover their immune systems faster after a stem cell transplant for leukemia. It involves giving patients a special, filtered portion of their donor's immune cells, aiming to reduce the risk of life-threatening viral and fungal…

This early-stage study is testing whether an experimental drug called LP-118 can be safely combined with an approved leukemia drug, ponatinib, and standard chemotherapy. The goal is to find the safest and most effective dose for patients whose T-cell acute lymphoblastic leukemia …

This program provides access to an experimental drug called AVM0703 for patients with various solid tumors and blood cancers. It is for people who may not have other treatment options. The drug aims to help the body's immune system fight cancer, and early reports show mostly mild…

This study is testing whether changing the timing of a standard immune-suppressing drug (ATG) can better prevent severe graft-versus-host disease (GVHD) after a stem cell transplant. The trial will enroll 56 adults with acute leukemia, myelodysplastic syndrome, or myeloproliferat…

This study is for people with acute leukemia or myelodysplastic syndrome (MDS) who need a stem cell transplant from a donor. The main goal is to find the best way to reduce a serious complication called graft-versus-host disease (GVHD), where the donor's immune cells attack the p…

This early-stage trial is testing a new approach to stem cell transplants for adults with advanced blood cancers like leukemia. Researchers are modifying the donor cells by adding specific immune cells (regulatory T-cells) alongside the standard transplant. The goal is to help th…

This early-stage trial is testing whether adding an experimental drug called ziftomenib to standard leukemia treatments is safe and tolerable for patients. It focuses on adults with acute myeloid leukemia (AML) that has returned or not responded to prior therapy and has specific …

This study is testing a new diagnostic platform called IT-TCP that analyzes tumor samples from patients with high-risk cancers. Researchers will collect samples from 300 patients with various cancers including leukemia, pancreatic cancer, and melanoma to see if this detailed anal…

This study is testing whether using virtual reality (VR) headsets can help children and teenagers with leukemia feel less pain and anxiety when they need repeated needle insertions into their chest port for treatment. Over 3 months, researchers will compare VR distraction to stan…

This study is testing whether a new support program called EASE can help reduce the severe emotional distress and physical symptoms people often experience after being diagnosed with acute leukemia. About 266 newly diagnosed patients will be randomly assigned to receive either th…

This study aims to understand how stem cell transplants for acute leukemia affect women's reproductive health. Researchers will review medical records of 80 women who received transplants as adults to document gynecological complications like early menopause and fertility issues.…

This study aims to understand the barriers that prevent eligible blood cancer patients from receiving a potentially curative stem cell transplant. Researchers will observe over 1,300 adults with acute leukemia, myelodysplastic syndrome, or myeloproliferative neoplasms to track wh…

This study aims to better understand various blood cancers by analyzing patient samples using multiple advanced laboratory techniques. Researchers will examine bone marrow, blood, and tissue samples from 1,040 patients across Italy, both from past collections and new participants…

This study aims to discover new genes that cause cancer to run in families, especially those affecting children. Researchers will collect health information, blood, and sometimes leftover tumor samples from families where multiple members have had cancer. The goal is to build a l…

This study aims to find new treatments for blood cancers like leukemia. Researchers will test hundreds of approved and experimental drugs on cancer cells taken from 250 patients. The goal is to see which drugs work best on different types of cancer cells and to learn why, which c…