New cell addback could shield kids from deadly infections after transplant
NCT ID NCT03810196
First seen Jun 25, 2026 · Last updated Jul 09, 2026 · Updated 3 times
Summary
This study tests whether giving children with leukemia a special type of donor immune cell (CD45RA-depleted) after a stem cell transplant can help their immune system recover faster and lower the risk of serious viral or fungal infections. The trial enrolls 50 children under 25 who are at high risk for infections after transplant. The approach aims to balance preventing graft vs. host disease while boosting infection-fighting ability.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- CD45RA-depleted donor immune cells
- What this could lead to
- If it works, this could lower the risk of life-threatening infections after a stem cell transplant for children with leukemia.
- What could go wrong
- This is an early, small trial (50 participants) testing a complex cell-processing procedure. It may not reduce infections or GVHD as hoped, and there are risks of immune reactions or treatment failure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Children's Hospital of Philadelphia
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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