New hope for tough leukemias: experimental pill targets genetic weakness

NCT ID NCT04065399

Recruiting now Disease control Sponsor: Syndax Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an oral drug called revumenib in people with certain types of leukemia that have relapsed or not responded to standard therapy. The trial has two parts: first, finding the best dose, then testing that dose in four groups based on leukemia type. About 447 participants will take part to see if the drug can shrink the cancer and how safe it is.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: revumenib (also called SNDX-5613), taken orally
What this could lead to: If successful, this could provide a new treatment option for people with hard-to-treat leukemias that have specific genetic changes.
What could go wrong: This is an early-phase trial, so the drug may not work or could cause serious side effects. It is only for patients who have not responded to other treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

acute biphenotypic leukemia acute leukemia acute leukemia of ambiguous lineage acute lymphoblastic leukemia acute myeloid leukemia leukemia mixed phenotype acute leukemia Precursor Cell Lymphoblastic Leukemia-Lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE LEUKEMIA OF AMBIGUOUS LINEAGE ACUTE LYMPHOBLASTIC LEUKEMIA ACUTE MYELOID LEUKEMIA MIXED LINEAGE ACUTE LEUKEMIA MIXED PHENOTYPE ACUTE LEUKEMIA

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••

Locations

Alfred Hospital
RECRUITING

Melbourne, 3004, Australia
Centre Hospitalier Lyon Sud
RECRUITING

Pierre-Bénite, 69495, France
Centre Hospitalier Universitaire (CHU) de Bordeaux
RECRUITING

Pessac, 33604, France
Children's Healthcare of Atlanta
COMPLETED

Atlanta, Georgia, 30329, United States
City of Hope Comprehensive Cancer Center
ACTIVE_NOT_RECRUITING

Duarte, California, 91010, United States
Dana Farber Cancer Institute
ACTIVE_NOT_RECRUITING

Boston, Massachusetts, 02215, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27110, United States
Emory Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States
Florida Cancer Specialists and Research Institute
ACTIVE_NOT_RECRUITING

Sarasota, Florida, 34232, United States
Galilee Medical Center
RECRUITING

Nahariya, 2210010, Israel
Hackensack University Medical Center
COMPLETED

Hackensack, New Jersey, 07601, United States
Hadassah Medical Center- Ein Kerem
RECRUITING

Jerusalem, 9112001, Israel
Hospital Centro Comprensivo de Cancer UPR
RECRUITING

San Juan, 00935, Puerto Rico
Hospital Saint-Louis - APHP
RECRUITING

Paris, 75010, France
Hospital Universitari i Politecnic La Fe de Valencia
RECRUITING

Valencia, 46026, Spain
Hospital Universitario Virgen del Rocio
RECRUITING

Seville, 41013, Spain
Huntsman Cancer Institute at the University of Utah
COMPLETED

Salt Lake City, Utah, 84112, United States
IRCCS Azienda Ospedaliero Universitaria di Bologna
RECRUITING

Bologna, 40138, Italy
IRCCS-Istituto Europeo di Oncologia
RECRUITING

Milan, 20141, Italy
Institut Catala d'Oncologia (ICO) - Hospital Duran i Reynals
RECRUITING

L'Hospitalet de Llobregat, 08908, Spain
Institut Gustave Roussy-Gustave Roussy Cancer Center -DITEP
RECRUITING

Villejuif, 94805, France
Istituto Romagnolo Per Lo Studio dei tumori Dino Amadori
RECRUITING

Meldola, 47014, Italy
Klinikum Nuernberg Nord
COMPLETED

Nuremberg, 90419, Germany
Memorial Sloan Kettering Cancer Center
ACTIVE_NOT_RECRUITING

New York, New York, 10065, United States
Moffitt Cancer Center
COMPLETED

Tampa, Florida, 33162, United States
Montefiore Medical Center
RECRUITING

New York, New York, 10467, United States
Ohio State University
RECRUITING

Columbus, Ohio, 43201, United States
Oregon Health & Science University
RECRUITING

Portland, Oregon, 97239, United States
Peter MacCallum Cancer Centre (PMCC)
ACTIVE_NOT_RECRUITING

Melbourne, Victoria, 3000, Australia
Princess Maxima Center for Pediatric Oncology
RECRUITING

Utrecht, 3584 CS, Netherlands
Rabin Medical Center
RECRUITING

Petah Tikva, 4941492, Israel
Rambam Health Care Campus (RHCC)
RECRUITING

Haifa, 3109601, Israel
Royal Melbourne Hospital (RMH)
ACTIVE_NOT_RECRUITING

Parkville, Victoria, 3050, Australia
Royal North Shore Hospital
RECRUITING

Saint Leonards, 2065, Australia
S Bortolo Hospital AULSS 8 Berica
RECRUITING

Vicenza, 36100, Italy
Shaare Zedek Medical Center
RECRUITING

Jerusalem, 9103102, Israel
Sheba Medical Center
RECRUITING

Ramat Gan, 52621, Israel
Sir Charles Gairdner Hospital
RECRUITING

Nedlands, 6009, Australia
Stanford Cancer Institute
ACTIVE_NOT_RECRUITING

Palo Alto, California, 94305, United States
The Hospital for Sick Children
ACTIVE_NOT_RECRUITING

Toronto, Canada
The University of Chicago Medical Center
RECRUITING

Chicago, Illinois, 60637, United States
The University of Texas MD Anderson Cancer Center
ACTIVE_NOT_RECRUITING

Houston, Texas, 77030, United States
Universita Cattolica Fondazione Policlinico Agostino Gemelli
RECRUITING

Roma, 00168, Italy
Universitaetsklinikum Essen (AoR)
WITHDRAWN

Essen, 45147, Germany
Universitaetsklinikum Hamburg-Eppendorf
RECRUITING

Hamburg, 20246, Germany
Universitaetsmedizin Der Johannes
RECRUITING

Gutenberg, 55131, Germany
Universitaetsmedizin Greifswald
COMPLETED

Greifswald, 17475, Germany
University Health Network
RECRUITING

Toronto, M5G 2M9, Canada
University Hospital Of Ulm, Universitatsklinikum Ulm
RECRUITING

Ulm, Baden-Wurttemberg, 89081, Germany
University Of California Care Medical Group - Norris Comprehensive Cancer Center And Hospital
COMPLETED

Los Angeles, California, 90033, United States
University of Cincinnati
COMPLETED

Cincinnati, Ohio, 45267, United States
University of Colorado
RECRUITING

Aurora, Colorado, 80045, United States
University of Iowa Hospital
RECRUITING

Iowa City, Iowa, 52246, United States
University of Leipzig
RECRUITING

Leipzig, 04103, Germany
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Vilnius University Hospital Santaros Klinikos
RECRUITING

Vilnius, 08661, Lithuania
Washington University in St. Louis School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.