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Hunt for hidden cancer genes: families needed to unlock hereditary secrets

NCT ID NCT03050268

Recruiting now Knowledge-focused Sponsor: St. Jude Children's Research Hospital Source: ClinicalTrials.gov ↗

First seen Jan 04, 2026 · Last updated Jun 18, 2026 · Updated 28 times

Summary

This study aims to discover new genes that may cause certain cancers to run in families. Researchers will collect blood samples and health information from 1,500 people in families where multiple members have had cancer, especially childhood cancers. The goal is to build a registry and sample bank to help future diagnosis and care. Participants may not receive individual results, but the knowledge gained could improve understanding of hereditary cancer.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • St. Jude Children's Research Hospital

    RECRUITING

    Memphis, Tennessee, 38105, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

The condition(s) this trial relates to.

acute leukemia acute myeloid leukemia Adenomatous Polyposis Coli adrenal carcinoma adrenal cortex carcinoma atypical teratoid rhabdoid tumor BAP1-related tumor predisposition syndrome Carney complex choroid plexus carcinoma classic familial adenomatous polyposis Colorectal Neoplasms, Hereditary Nonpolyposis Cowden disease deafness-lymphedema-leukemia syndrome Diamond-Blackfan anemia DICER1-related tumor predisposition dyskeratosis congenita familial atypical multiple mole melanoma syndrome Fanconi anemia gastrointestinal stromal tumor GATA2 Deficiency hereditary breast ovarian cancer syndrome hereditary neoplastic syndrome hereditary pheochromocytoma-paraganglioma hereditary Wilms tumor Hodgkins lymphoma inherited acute myeloid leukemia inherited disease susceptibility juvenile polyposis syndrome Li-Fraumeni syndrome Lynch syndrome malignant pancreatic neoplasm melanoma mismatch repair cancer syndrome mismatch repair cancer syndrome 1 multiple endocrine neoplasia type 1 multiple endocrine neoplasia type 2 multiple endocrine neoplasia type 2A myelodysplastic syndrome neuroblastoma Neurofibromatosis 2 neurofibromatosis type 1 nevoid basal cell carcinoma syndrome NF2-related schwannomatosis non-Hodgkin lymphoma Noonan syndrome overgrowth syndrome pancreatic neoplasm paraganglioma Peutz-Jeghers syndrome pheochromocytoma pheochromocytoma-paraganglioma PTEN hamartoma tumor syndrome RASopathy retinoblastoma rhabdomyosarcoma Rothmund-Thomson syndrome tuberous sclerosis von Hippel-Lindau disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE LEUKEMIA ADENOMATOUS POLYPOSIS ADRENOCORTICAL CARCINOMA AML BAP1 TUMOR PREDISPOSITION SYNDROME CARNEY COMPLEX CHOROID PLEXUS CARCINOMA CONSTITUTIONAL MISMATCH REPAIR DEFICIENCY SYNDROME DIAMOND-BLACKFAN ANEMIA DICER1 SYNDROME DYSKERATOSIS CONGENITA EMBERGER SYNDROME FAMILIAL ACUTE MYELOID LEUKEMIA FAMILIAL ADENOMATOUS POLYPOSIS FAMILIAL CANCER FAMILIAL NEUROBLASTOMA FAMILIAL WILMS TUMOR FANCONI ANEMIA GIST HEREDITARY BREAST AND OVARIAN CANCER HEREDITARY PARAGANGLIOMA-PHEOCHROMOCYTOMA SYNDROME HODGKIN LYMPHOMA JUVENILE POLYPOSIS LI-FRAUMENI SYNDROME LI-FRAUMENI SYNDROME LYNCH SYNDROME LYNCH SYNDROME MDS MELANOMA SYNDROME MELANOMA SYNDROME MULTIPLE ENDOCRINE NEOPLASIA TYPE 1 MULTIPLE ENDOCRINE NEOPLASIA TYPE 2 MULTIPLE ENDOCRINE NEOPLASIA TYPE 2 MULTIPLE ENDOCRINE NEOPLASIA, TYPE 1 NEUROBLASTOMA NEUROBLASTOMA NEUROFIBROMATOSIS TYPE 1 NEUROFIBROMATOSIS TYPE II NEVOID BASAL CELL CARCINOMA SYNDROME NON HODGKIN LYMPHOMA NON-HODGKIN LYMPHOMA NOONAN SYNDROME AND OTHER RASOPATHY OVERGROWTH SYNDROMES PANCREATIC CANCER PEUTZ-JEGHERS SYNDROME PHEOCHROMOCYTOMA/PARAGANGLIOMA PTEN HAMARTOMA TUMOR SYNDROME RETINOBLASTOMA RHABDOID TUMOR PREDISPOSITION SYNDROME RHABDOMYOSARCOMA ROTHMUND-THOMSON SYNDROME TUBEROUS SCLEROSIS VON HIPPEL-LINDAU DISEASE