Hunt for hidden cancer genes: families needed to unlock hereditary secrets

NCT ID NCT03050268

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to discover new genes that may cause certain cancers to run in families. Researchers will collect blood samples and health information from 1,500 people in families where multiple members have had cancer, especially childhood cancers. The goal is to build a registry and sample bank to help future diagnosis and care. Participants may not receive individual results, but the knowledge gained could improve understanding of hereditary cancer.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ACUTE LEUKEMIA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

acute leukemia acute myeloid leukemia Adenomatous Polyposis Coli adrenal carcinoma adrenal cortex carcinoma atypical teratoid rhabdoid tumor BAP1-related tumor predisposition syndrome Carney complex choroid plexus carcinoma classic familial adenomatous polyposis Colorectal Neoplasms, Hereditary Nonpolyposis Cowden disease deafness-lymphedema-leukemia syndrome Diamond-Blackfan anemia DICER1-related tumor predisposition dyskeratosis congenita familial atypical multiple mole melanoma syndrome Fanconi anemia gastrointestinal stromal tumor GATA2 Deficiency hereditary breast ovarian cancer syndrome hereditary neoplastic syndrome hereditary pheochromocytoma-paraganglioma hereditary Wilms tumor Hodgkins lymphoma inherited acute myeloid leukemia inherited disease susceptibility juvenile polyposis syndrome Li-Fraumeni syndrome Lynch syndrome malignant pancreatic neoplasm melanoma mismatch repair cancer syndrome mismatch repair cancer syndrome 1 multiple endocrine neoplasia type 1 multiple endocrine neoplasia type 2 multiple endocrine neoplasia type 2A myelodysplastic syndrome neuroblastoma Neurofibromatosis 2 neurofibromatosis type 1 nevoid basal cell carcinoma syndrome NF2-related schwannomatosis non-Hodgkin lymphoma Noonan syndrome overgrowth syndrome pancreatic neoplasm paraganglioma Peutz-Jeghers syndrome pheochromocytoma pheochromocytoma-paraganglioma PTEN hamartoma tumor syndrome RASopathy retinoblastoma rhabdomyosarcoma Rothmund-Thomson syndrome tuberous sclerosis von Hippel-Lindau disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • St. Jude Children's Research Hospital

    RECRUITING

    Memphis, Tennessee, 38105, United States

    Contact Email: •••••@•••••

More trials for these conditions

Other studies related to the condition(s) this trial covers.