LYNCH SYNDROME

This study tests a new tool: a capsule about the size of a fish oil pill attached to a string that takes pictures inside the lower gut. It is inserted without sedation and moves slowly upward using a motor. The goal is to see if it can get clear images of the lower GI tract in 30…

This study looks at whether people with Lynch syndrome can collect their own vaginal samples at home to check for early signs of uterine cancer. About 30 participants will use a self-collection kit and answer health surveys. The goal is to see if this method is easy, acceptable, …

This study is testing a blood test (called a liquid biopsy) to see how well it can find colorectal cancer, advanced polyps, and Lynch syndrome-related cancers early. Researchers will enroll 1,200 people who have had a colonoscopy and take a blood sample to compare the test result…

This study looks at whether a menstrual cup can collect enough tissue from the uterus to screen for cancer, as an alternative to a standard biopsy. It involves 25 women with Lynch syndrome, who are at higher risk for uterine cancer. Participants will use a menstrual cup at home a…

This study is for people aged 50–75 with Lynch syndrome, a genetic condition that raises the risk of several cancers, including bladder and urinary tract cancers. Researchers want to see if a urine test that looks for tumor DNA can find these cancers early, before symptoms appear…

This early-stage study tests a new vaccine made from a person's own immune cells to prevent cancer in people with Lynch syndrome, a genetic condition that raises cancer risk. The vaccine is designed to train the immune system to recognize and attack cells that might become cancer…

This study tests whether a digital app (Open Food Facts) plus nutrition education can help 170 people at high risk for breast, pancreas, colon cancer, or with Lynch syndrome or BRCA mutations improve their diet quality. Participants will use the app to reduce ultra-processed food…

This study tests whether naproxen or aspirin can increase immune cells in the colon to prevent cancer in people with Lynch syndrome, a genetic condition that raises cancer risk. About 40 participants will take one of these drugs or a placebo for a short time. Researchers will mea…

This study looks at how the immune system's surveillance affects the development of colorectal cancer in people with Lynch syndrome, a genetic condition that raises cancer risk. Researchers will follow 300 participants with Lynch syndrome who are already undergoing regular cancer…

This study compares an artificial intelligence system called CAD-EYE to the standard dye-spray technique for finding polyps during colonoscopy in people with Lynch syndrome. Lynch syndrome is a genetic condition that greatly increases the risk of colorectal cancer. The goal is to…

This research study aims to discover new genes that may cause cancer to run in families. Researchers will collect blood samples and health information from 1,500 people in families where multiple members have had childhood cancers. Participants will not receive direct treatment o…

This study offers free genetic testing to the general public to find people with inherited cancer syndromes, like hereditary breast and ovarian cancer or Lynch syndrome. Researchers want to see if broad testing is better than only testing those with a family history. Up to 27,500…

This study reviews past medical records of 400 people with Lynch syndrome who had a small bowel capsule endoscopy (a camera in a pill) to screen for early growths or cancer. The goal is to see how well this test finds precancerous or cancerous lesions in the small bowel. Results …

This study is testing a new way to find early signs of pancreas cancer in people at high risk, such as those with a strong family history or certain gene mutations. Researchers will collect and analyze pancreatic juice during a routine endoscopy to look for cancer markers. The go…

This study looks at how well a tiny camera you swallow (videocapsule endoscopy) can find early signs of small bowel cancer in people with Lynch syndrome. About 100 adults with Lynch syndrome will swallow the camera pill as part of their regular care. Researchers will track how ma…

This study aims to collect blood samples (liquid biopsies) from 2,500 people with cancer or at high risk for cancer, along with their medical information. The samples will be stored and used by researchers to develop better ways to detect, monitor, and understand cancer over time…

This study is creating a large database of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand what causes cancer, how it progresses, and how to improve p…