LYNCH SYNDROME

This study is looking back at past medical records to see how effective a tiny, swallowable camera (capsule endoscopy) is at finding early signs of cancer in the small intestine of people with Lynch syndrome. Lynch syndrome is a genetic condition that increases a person's risk fo…

This study is testing whether a new computer system that uses artificial intelligence (AI) can be as good as the current best method at finding pre-cancerous growths during colonoscopies. It involves people with Lynch syndrome, a genetic condition that greatly increases the risk …

This study is testing whether a menstrual cup used at home can collect good samples from the lining of the uterus to screen for cancer. It compares the cup samples to those taken during a standard, more invasive biopsy procedure. The goal is to find a gentler and more convenient …

This study is testing a new urine test that looks for cancer DNA to find bladder and urinary tract cancers early in people with Lynch syndrome. Lynch syndrome is a genetic condition that makes people much more likely to develop several types of cancer. The goal is to see if this …

This study is testing whether women with Lynch syndrome can use simple home vaginal swabs to detect early signs of uterine cancer. Researchers want to see if these self-collected samples can find DNA changes that might indicate cancer risk. The study also checks if participants f…

This study is testing a new, low-cost tool to take pictures inside the lower intestines. The tool is a tiny capsule, about the size of a vitamin pill, attached to a thin string. Doctors will gently guide the capsule up the colon in awake participants to see if it can capture clea…

This study is testing a new blood test to see if it can accurately detect colorectal cancer and precancerous growths called adenomas. It aims to provide a less invasive screening option to help find these conditions earlier. The test will also be evaluated for people with Lynch s…

This is a first-in-human study testing a personalized vaccine called DC-DELAY, designed to prevent cancer in people with Lynch syndrome—a genetic condition that greatly increases cancer risk. The trial will enroll 20 participants to primarily check if the vaccine is safe and if i…

This study is testing whether two common over-the-counter pain relievers, aspirin or naproxen, can help prevent cancer in people with Lynch syndrome, a genetic condition that greatly increases cancer risk. Researchers will give 40 participants one of the drugs for a year and use …

This large study aims to find better ways to detect pancreatic cancer early in people at high genetic risk. Researchers will collect and analyze pancreatic fluid from 9,000 participants during scheduled endoscopies, looking for biological markers that signal developing cancer. Th…

This study aims to create a library of blood samples from cancer patients and people at high risk for cancer. Researchers will collect these 'liquid biopsies' to help future studies develop better ways to detect cancer early and monitor treatment. The study involves 2,500 partici…

This study aims to discover new genes that cause cancer to run in families, especially those affecting children. Researchers will collect health information, blood, and sometimes leftover tumor samples from families where multiple members have had cancer. The goal is to build a l…

This study is building a large, long-term database of health information and biological samples from people with cancer, people at risk for cancer, and healthy volunteers. The goal is to collect this data to help researchers better understand what causes cancer and how to prevent…

This study is testing a new approach to finding people at high risk for inherited cancers. Researchers are offering free genetic testing to the general public to see if this broad screening catches more at-risk people than the current method, which only tests those with a known f…