LYNCH SYNDROME

This study tests a vaccine called Nous-209 in 45 people with Lynch syndrome, an inherited condition that raises the risk of colorectal and other cancers. The vaccine is designed to train the immune system to recognize and attack cells with cancer-like changes. Researchers want to…

This study was designed to test two immunotherapy drugs, nivolumab and ipilimumab, in children and young adults with cancers that returned or didn't respond to treatment and have many genetic mutations. The goal was to see if the combination could shrink tumors or help patients l…

This study tests whether adding the immunotherapy drug atezolizumab to standard chemotherapy can better prevent colon cancer from coming back in people with stage III colon cancer that has a specific DNA repair problem (dMMR). About 712 participants will receive either chemothera…

This early-stage trial is testing the safety and early effectiveness of a drug called pembrolizumab in children and young adults whose aggressive brain tumors have come back or stopped responding to standard treatments. The drug is a type of immunotherapy designed to help the bod…

This study tests a two-part vaccine (Tri-Ad5 plus N-803) to see if it can prevent colon cancer and precancerous growths in people with Lynch syndrome, a genetic condition that raises cancer risk. About 186 participants will receive either the vaccine or a placebo. The goal is to …

This study tests a program that helps people with BRCA+ or Lynch syndrome mutations lose weight and adopt healthier habits like better diet and more exercise. The goal is to see if these changes can lower their risk of developing cancer. About 384 participants and their family me…

This study tests a program to help 200 adults with hereditary cancer syndromes (like BRCA or Lynch syndrome) living in rural areas follow cancer prevention and screening guidelines. Participants get personalized care plans and regular check-ins over two years. The goal is to see …

This study tests different programs to help people at high risk for cancer eat healthier and exercise more. The goal is to see which approach works best to increase physical activity and improve diet. About 337 people with a high BMI, low activity, or poor diet are taking part. T…

This study looks at whether providing education materials helps relatives of people with Lynch syndrome decide about genetic counseling and testing. About 185 adult relatives will be randomly assigned to receive either a standard information letter or a letter plus a booklet. Res…

This study looks at whether people with Lynch Syndrome, a condition that raises the risk for several cancers, follow recommended screening guidelines after genetic counseling. Researchers will track up to 1,530 participants to see how many get the suggested tests and what factors…

This study is creating a large database of people at high risk for pancreatic cancer, including those with cysts, genetic syndromes, or other risk factors. The goal is to track their health over time to find better ways to detect and prevent the disease early. About 317 participa…

This study looks at whether a website and a genetic family navigator can help more family members of people with hereditary cancer get genetic testing. About 205 adults who have a known cancer gene mutation and their relatives will take part. The goal is to see if this approach m…

This study looks at how bacteria living in the gut and diet may increase colon cancer risk in people with Lynch syndrome or other inherited colon polyp conditions. Researchers collect stool, colon tissue samples, and diet/lifestyle questionnaires from 77 participants during routi…