LYNCH SYNDROME

This early-phase study aimed to test the safety and effectiveness of a two-drug immunotherapy combination (nivolumab and ipilimumab) in children, teens, and young adults. It was specifically for patients whose cancers had returned or stopped responding to standard treatments and …

This study is for people with stage III colon cancer that has a specific genetic feature (dMMR). It compares the standard chemotherapy treatment (FOLFOX) to that same chemotherapy plus an immunotherapy drug called atezolizumab. The goal is to see if adding the immunotherapy helps…

This early-stage trial is testing the safety and early effectiveness of a drug called pembrolizumab in children with aggressive brain tumors that have come back or stopped responding to standard treatments. The drug is an immunotherapy, which aims to help the body's own immune sy…

This study is testing different ways to help people at high risk for cancer or cancer survivors become more active and eat healthier foods. Researchers are comparing methods like weekly phone calls, emails, daily text messages, and online forums to see which combinations work bes…

This study is testing whether a structured, long-term follow-up program helps people with inherited cancer syndromes stick to recommended cancer screening and prevention plans. It focuses on 200 adults with known genetic mutations, especially those living in rural areas, who will…

This trial is testing a vaccine called Nous-209 in people with Lynch syndrome, a genetic condition that greatly increases the risk of colorectal and other cancers. The vaccine is designed to teach the body's immune system to recognize and attack early cancer cells. Researchers wa…

This study is testing whether a combination of a three-part vaccine and an immune system booster can prevent colon and other cancers in people with Lynch syndrome, a genetic condition that greatly increases cancer risk. The vaccine aims to train the body's immune system to recogn…

This study is testing different ways to help people with BRCA or Lynch syndrome gene mutations manage their weight and improve health habits to lower their cancer risk. Researchers are comparing methods like phone coaching, text message reminders, and family support groups to see…

This study is testing two different ways to share genetic test results related to breast cancer risk with African American women. Researchers want to see if an online, self-guided program works as well as the standard method of a phone call with a genetic counselor. The goal is t…

This study is testing whether educational materials help relatives of people with Lynch syndrome decide about getting genetic counseling and testing. About 185 relatives at risk will receive either a standard information letter or the letter plus an educational booklet. Researche…

This study aims to create a large database of patient information to find better ways to detect pancreatic cancer early, when it's most treatable. It involves 317 adults at Moffitt Cancer Center who have pancreatic cysts, a strong family history of pancreatic cancer, or other ris…

This study is testing a new program to help family members of people with hereditary cancer get genetic testing. The program includes a website and a personal guide. Researchers want to see if this approach makes it easier for families to understand and act on their genetic cance…

This study aims to understand if the bacteria living in our gut and our diet affect cancer risk in people with inherited conditions that make them prone to colon cancer. Researchers are collecting stool samples, colon tissue from routine colonoscopies, and diet questionnaires fro…

This study aims to understand if people with Lynch Syndrome, a genetic condition that increases cancer risk, follow through with the recommended screening tests for multiple organs after receiving genetic counseling. Researchers are observing over 1,500 adults who have received t…