Gut bacteria may hold key to cancer risk in lynch syndrome

NCT ID NCT02371135

Ongoing Knowledge-focused Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how bacteria living in the gut and diet might influence colorectal cancer risk in people with Lynch syndrome and other inherited colon conditions. Researchers will collect stool samples, colon biopsies, and diet questionnaires from 77 participants during routine colonoscopies. The goal is to better understand the link between gut microbes, diet, and cancer risk in these high-risk groups.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help identify dietary or bacterial factors that lower colorectal cancer risk in people with inherited syndromes.
What could go wrong: This is an observational study, not a treatment trial. It cannot prove cause and effect, and results may not lead to direct clinical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Colorectal Neoplasms, Hereditary Nonpolyposis intestinal polyposis syndrome Lynch syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEREDITARY COLONIC POLYPOSIS SYNDROMES LYNCH SYNDROME

Contacts and locations

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Locations

Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States

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