Can a walking routine alter cancer biomarkers? new trial investigates

NCT ID NCT03996239

Ongoing Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time

Summary

This study explores whether regular aerobic exercise, specifically walking about 300 minutes per week, can change certain biomarkers in the blood that are linked to cancer risk. Participants are adults who have completed all cancer therapy and have either clonal hematopoiesis (a blood condition) or a solid tumor with residual disease. The trial uses a home-based, digitally monitored exercise program to see if exercise can intercept cancer progression.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: aerobic exercise (walking)
What this could lead to: If it works, this could show that exercise can reduce cancer-related biomarkers, pointing toward a non-drug way to lower cancer risk.
What could go wrong: This is a small early-stage proof-of-concept trial, so results may not be conclusive or apply to everyone. Exercise adherence may vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer cancer clonal hematopoiesis colorectal cancer Lynch syndrome neoplasm prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANCER

Contacts and locations

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Locations

Duke University Medical Center (Data or Specimen Analysis Only)

Durham, North Carolina, 27701, United States
LABORATORY CORPORATION OF AMERICA HOLDINGS (Data or Specimen Analysis Only)

Burlington, North Carolina, 27215, United States
Memorial Sloan Kettering Bergen

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Commack

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester

Harrison, New York, 10604, United States
SOMALOGIC (Data or Specimen Analysis Only)

Boulder, Colorado, 80301, United States
University of California, Los Angeles (Data or Specimen Analysis Only)

Los Angeles, California, 90095, United States

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