LYNCH SYNDROME

This early-stage trial tests a personalized vaccine made from a person's own immune cells to prevent cancer in people with Lynch syndrome, a genetic condition that raises cancer risk. The vaccine is designed to train the immune system to recognize and attack potential tumor cells…

This study looks at whether simple, non-invasive tests like blood, urine, stool, and vaginal swabs can help predict cancer in people with Lynch syndrome, a genetic condition that raises cancer risk. Researchers will compare these liquid biopsies to standard procedures like colono…

This study tests an online tool called Let's Talk to help people with Lynch syndrome encourage their relatives to get screened for cancer. Researchers will work with 20 participants (15 patients and 5 genetic counselors) to see if the tool is easy to use and improves knowledge. T…

This study checks if a newer, cheaper DNA sequencing machine (MGI) works as well as the current standard (Illumina) for finding gene changes linked to hereditary cancers like breast, ovarian, and Lynch syndrome. Researchers will compare results from 248 stored DNA samples using b…

This study looks at 150 people with Lynch syndrome to find out how many also have Muir-Torre syndrome, a condition that raises the risk for certain skin cancers. Researchers will check medical records and skin samples to spot new signs of the syndrome and build a tissue bank for …

This study tests a web-based program called Kindred that helps African American families understand their genetic cancer risk and talk about testing. About 150 people will use the online tool to learn about hereditary cancer syndromes like BRCA and Lynch. The goal is to see if th…

This study looks at whether a tiny camera in a capsule, which you swallow, can be a good alternative to standard colonoscopy for people with Lynch syndrome. Lynch syndrome greatly raises the risk of colon cancer, so regular screening is important. The capsule camera is less invas…