Liquid biopsies may let lynch syndrome patients skip half their colonoscopies
NCT ID NCT07360834
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether annual liquid biopsies (from blood, urine, stool, and vaginal swabs) can safely replace colonoscopies every 18 months for people with Lynch syndrome. 2,000 participants will be split into two groups: one gets standard care (colonoscopy every 18 months), the other gets liquid biopsies plus a colonoscopy every 36 months. The goal is to see if the liquid biopsy approach catches cancers just as early, while being less invasive and more convenient.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
liquid biopsy (blood, urine, stool, vaginal swab) and colonoscopy
What this could lead to
If successful, this could allow people with Lynch syndrome to have fewer invasive colonoscopies while still catching cancers early, improving quality of life.
What could go wrong
This is a large but early-stage study that has not yet started recruiting. Liquid biopsies may miss some early cancers, and the approach must prove it is as safe as standard care.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Erasmus Medisch Centrum Rotterdam
Rotterdam, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GGC Network
Paris, France
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Contact
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Ist. Tumori di Milano
Milan, Italy
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Klinicki Bolnicki Centar Sestre Milosrdnice Ustanova
Zagreb, Croatia
Contact Email: •••••@•••••
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Masaryk Memorial Cancer Institute
Brno, Czechia
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Oslo University Hospital
Oslo, Norway
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Pauls Stradins Clinical University Hospital
Riga, Latvia
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Tampereen Korkeakoulusäätiö SR
Helsinki, Finland
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University of Edinburgh
Edinburgh, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••