Liquid biopsies may let lynch syndrome patients skip half their colonoscopies

NCT ID NCT07360834

Not yet recruiting Diagnosis Sponsor: UNICANCER Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 04, 2026 · Updated 3 times

Summary

This study tests whether annual liquid biopsies (from blood, urine, stool, and vaginal swabs) can safely replace colonoscopies every 18 months for people with Lynch syndrome. 2,000 participants will be split into two groups: one gets standard care (colonoscopy every 18 months), the other gets liquid biopsies plus a colonoscopy every 36 months. The goal is to see if the liquid biopsy approach catches cancers just as early, while being less invasive and more convenient.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: liquid biopsy (blood, urine, stool, vaginal swab) and colonoscopy
What this could lead to: If successful, this could allow people with Lynch syndrome to have fewer invasive colonoscopies while still catching cancers early, improving quality of life.
What could go wrong: This is a large but early-stage study that has not yet started recruiting. Liquid biopsies may miss some early cancers, and the approach must prove it is as safe as standard care.

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Conditions

The condition(s) this trial relates to.

Colorectal Neoplasms, Hereditary Nonpolyposis Lynch syndrome mismatch repair cancer syndrome 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LYNCH SYNDROME

Contacts and locations

Locations

Erasmus Medisch Centrum Rotterdam

Rotterdam, Netherlands
GGC Network

Paris, France
Ist. Tumori di Milano

Milan, Italy
Klinicki Bolnicki Centar Sestre Milosrdnice Ustanova

Zagreb, Croatia
Masaryk Memorial Cancer Institute

Brno, Czechia
Oslo University Hospital

Oslo, Norway
Pauls Stradins Clinical University Hospital

Riga, Latvia
Tampereen Korkeakoulusäätiö SR

Helsinki, Finland
University of Edinburgh

Edinburgh, United Kingdom

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