Weight loss program aims to cut cancer risk in BRCA and lynch syndrome carriers

NCT ID NCT04125914

Ongoing Disease control Sponsor: M.D. Anderson Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a weight management and health behavior program for people with BRCA or Lynch syndrome mutations, who have a higher risk of certain cancers. Participants receive diet tracking, exercise guidance, phone coaching, and online support to help them lose weight and adopt healthier habits. The goal is to see if these lifestyle changes can lower cancer risk in this high-risk group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: behavioral intervention (diet, exercise, coaching, text messages, Facebook group)
What this could lead to: If successful, this program could help people with hereditary cancer mutations lower their cancer risk through lifestyle changes.
What could go wrong: This is an early-stage behavioral study, not a drug trial. Results depend on participants sticking with the program, and it may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Colorectal Neoplasms, Hereditary Nonpolyposis familial ovarian carcinoma hereditary breast carcinoma hereditary breast ovarian cancer syndrome Lynch syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEREDITARY BREAST CARCINOMA HEREDITARY OVARIAN CARCINOMA LYNCH SYNDROME

Contacts and locations

Locations

M D Anderson Cancer Center

Houston, Texas, 77030, United States

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