M.d. Anderson Cancer Center

This study tests whether a personalized cell therapy called liso-cel can stop large B-cell lymphoma from returning in patients who still have traces of cancer DNA after initial treatment. About 50 adults who are in remission but test positive for lymphoma DNA will receive their o…

This early-phase study tests a combination of three drugs (avutometinib, defactinib, and everolimus) in people with recurrent endometrial cancer that has specific genetic changes in the RAS pathway. The main goal is to find a safe dose and understand side effects. About 31 partic…

This study tests whether a combination of three drugs—adagrasib, cetuximab, and cemiplimab—can help control metastatic colorectal cancer in people whose tumors have a specific genetic change called KRAS G12C. About 31 adults whose cancer has not responded to at least one prior tr…

This early-stage trial tests a new type of immune cell therapy for people with several kinds of blood cancers that have come back or stopped responding to treatment. The therapy uses natural killer (NK) cells from donated cord blood, which are genetically modified to better recog…

This Phase 3 trial tests whether personalizing apalutamide treatment based on cancer aggressiveness can reduce fatigue and other side effects in men with prostate cancer who have detectable PSA after prostatectomy. About 120 participants will receive either standard therapy or a …

This phase II trial is testing whether patients with early HER2-positive or triple-negative breast cancer who had a complete response to pre-surgery treatment and have no cancer DNA in their blood can safely receive less therapy after surgery. The goal is to reduce side effects w…

This early-phase trial is testing a new drug called HC-7366 in 18 adults with acute myeloid leukemia (AML) that has come back or not responded to other treatments. The main goal is to find a safe dose and check for side effects. Researchers hope this drug may offer a new option f…

This study tests whether combining two drugs, dostarlimab and LB-100, can help control ovarian clear cell carcinoma. About 21 adults with recurrent disease will receive the drugs by vein. The main goal is to check safety and see if the tumors shrink or stop growing.

This phase 2 trial tests whether giving two drugs, cemiplimab and cetuximab, before salvage surgery can help control recurrent oral cavity squamous cell carcinoma. The study involves 17 adults whose cancer has returned at least 3 months after prior treatment. Researchers will mon…

This study tests whether adding the drug niraparib to standard hormone therapy after radiation helps control high-risk prostate cancer that hasn't spread far. About 200 men will receive either hormone therapy alone or hormone therapy plus niraparib. The goal is to see if the comb…

This study looks at how well a combination of four chemotherapy drugs (gemcitabine, docetaxel, melphalan, and carboplatin) followed by a stem cell transplant works in children and teens up to age 21 whose germ cell tumors have come back or not responded to treatment. Researchers …

This early-phase trial is testing a combination of two drugs—Hyper-CVAD chemotherapy and venetoclax—in 22 children and young adults whose leukemia has returned or not responded to treatment. The main goal is to find a safe dose and monitor side effects. If the combination proves …

This phase 2 trial tests a daily oral drug called zanzalintinib in 70 adults with advanced or metastatic bone sarcomas that cannot be removed by surgery. The study includes four groups based on sarcoma type. Researchers will check if the drug is safe and helps control the cancer.

This early-stage trial tests a new therapy made from cord blood immune cells that are engineered to better target and attack head and neck cancer cells. Up to 33 patients with advanced disease that has not responded to standard treatments will receive these cells along with low-d…

This study is testing a drug called inotuzumab ozogamicin, which is like a smart bomb that targets and kills leukemia cells, combined with low-intensity chemotherapy. The goal is to find the best dose and see if this combo works better than standard treatments for patients with a…

This study is for people with breast cancer who need a mastectomy (breast removal) followed by immediate breast reconstruction using their own tissue. It compares two ways of giving radiation before surgery: the standard longer course versus a shorter course with fewer, higher do…

This Phase 2 trial tests a combination of horse anti-thymocyte globulin, cyclosporine, steroids, and growth factors in 140 adults with aplastic anemia or low-risk myelodysplastic syndrome (MDS). The goal is to see if this immune-suppressing and blood-cell-boosting approach can im…

This early-phase study tests a chemotherapy drug (gemcitabine) given as a mist to breathe in. It is for people whose solid tumors have spread to the lungs and who have no standard treatment options. The main goal is to find the safest dose and watch for side effects. Up to 44 par…

This early-phase study tests a combination of four drugs (venetoclax, dexamethasone, bortezomib, and daratumumab) for teens and young adults aged 12 to 30 whose T-cell acute lymphoblastic leukemia or lymphoma has returned or not responded to prior treatment. The main goal is to c…

This pilot study tests whether a surgical procedure called lymphovenous bypass (LVB) can prevent lymphedema (chronic swelling) when done at the same time as lymph node removal in melanoma patients. About 20 adults with melanoma who need axillary or inguinal lymph node dissection …

This study tests whether the drug ubamatamab, alone or with cemiplimab, can help control rare cancers like renal medullary carcinoma and epithelioid sarcoma. About 40 adults with advanced or metastatic disease will receive the treatment to check safety and effectiveness. The goal…

This early-phase trial is testing whether combining the drug enfortumab vedotin with radiation therapy can help control locally advanced bladder cancer. About 41 adults with urothelial carcinoma of the bladder will receive the drug by IV along with radiation. The main goal is to …

This study looks at whether stem cell transplant patients can safely stop taking a medicine called letermovir earlier if their immune system shows a strong response to CMV. About 105 participants will be monitored to see if this approach reduces infections and side effects compar…

This phase 2 trial is testing a combination of two immune-based therapies—axicabtagene ciloleucel (a CAR T-cell therapy) and glofitamab (a bispecific antibody)—in 40 people with large B cell lymphoma that has relapsed or not responded to first treatment. The goal is to see if the…

This study is for people with a high-risk form of smoldering multiple myeloma, an early stage of blood cancer. The purpose is to test a drug called belantamab mafodotin to find the safest dose and see if it can control the disease. About 30 participants will receive the drug, and…

This early-phase study tests a new combination treatment for people with advanced pancreatic cancer that has spread or cannot be removed by surgery. The treatment uses specially engineered immune cells (NK cells) from donated cord blood, given through a belly infusion and a vein,…

This phase 2 trial is testing a drug called ivonescimab in 24 people with advanced cutaneous squamous cell carcinoma (a type of skin cancer) or castration-resistant prostate cancer. The goal is to see if the drug can help control the cancer and to check for side effects. Particip…

This early-phase trial tests whether adding natural killer (NK) cells from a healthy donor to the standard drugs azacitidine and venetoclax can help control acute myeloid leukemia (AML). About 32 adults with relapsed or hard-to-treat AML will receive the combination. The main goa…

This study is for people with stage IV cancer that has started to grow in only a few places (oligoprogression). It compares adding local treatments like radiation or surgery to all growing spots versus switching to a new systemic therapy. The goal is to see if this approach can b…

This early-phase trial is testing a combination of two oral drugs—venetoclax and decitabine/cedazuridine—in children and teens whose acute myeloid leukemia (AML) has returned or not responded to prior treatment. The study aims to find the safest dose and check for early signs tha…

This study tests whether specially grown donor immune cells (called cytotoxic T lymphocytes) can safely and effectively control BK and JC virus infections in people with weakened immune systems, such as those with cancer, HIV, or organ transplants. About 100 participants will rec…

This early-phase trial tests a combination of three drugs—ziftomenib, venetoclax, and gemtuzumab—in children and young adults (ages 3 to 21) with acute myeloid leukemia that has come back or not responded to treatment. The main goal is to find a safe dose and check for side effec…

This study tests a two-step treatment for hairy cell leukemia, a rare blood cancer. First, patients receive chemotherapy (cladribine) to kill cancer cells, then an immunotherapy drug (rituximab) to help the immune system attack any remaining cells. The goal is to see if adding ri…

This study combines three chemotherapy drugs (cladribine, idarubicin, cytarabine) with a targeted drug (quizartinib) to treat acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS). It includes up to 80 adults who are newly diagnosed or whose cancer has returne…

This phase 2 trial is testing a drug called ivonescimab in people with a specific type of breast cancer called invasive lobular carcinoma that has spread and no longer responds to hormone therapy. The study includes 29 adults whose cancer is either hormone-receptor positive or tr…

This study tests a combination of three drugs—ASTX727, venetoclax, and gilteritinib—for people with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome that has a FLT3 mutation. The drugs work in different ways to stop cancer cells from growing. The trial aims to f…

This phase 2 trial tests whether a combination of three drugs—avutometinib, defactinib, and cetuximab—can help control advanced colorectal cancer that has stopped responding to standard anti-EGFR treatment. About 33 participants will receive the drugs orally and intravenously. Th…

This phase 2 trial tests the drug avapritinib in 50 adults with advanced solid tumors that have mutations in the CKIT or PDGFRA genes. The drug blocks enzymes that help cancer cells grow. The main goal is to see how many patients' tumors shrink or disappear. Researchers will also…

This study tests whether giving belzutifan alone, pembrolizumab alone, or both together before kidney surgery can help control advanced clear cell kidney cancer. About 10 people with locally advanced disease will receive the drugs before partial or total kidney removal. The main …

This early-phase trial is testing a combination of two drugs—atezolizumab (an immunotherapy) and cabozantinib (a targeted therapy)—in patients whose glioblastoma has returned after standard treatment. The goal is to see if the combination is safe and can help control the cancer. …

This study tests whether adding the investigational drug NKTR-255 to the standard immunotherapy durvalumab can help restore immune cells after chemoradiation in people with advanced non-small cell lung cancer. About 39 adults will receive the combination and be followed for overa…

This phase 2 study is testing whether adding talazoparib to standard hormone therapy and enzalutamide can help men with prostate cancer that has spread to lymph nodes. About 30 participants will take the drug combination before having their prostate removed. The goal is to see if…

This study tests a new treatment for people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that has come back or not responded to standard therapy. The treatment uses specially engineered natural killer (NK) cells designed to recognize and attack cancer cells…

This study tests a combination of two drugs, CPX-351 and ivosidenib, in about 30 adults with a specific genetic form of acute myeloid leukemia or high-risk myelodysplastic syndrome. The goal is to see if the combo can shrink or control the cancer. Participants must have the IDH1 …

This phase 2 study tests asciminib, a daily pill, in 40 adults with chronic myeloid leukemia whose first treatment with a TKI drug didn't work or caused side effects. Participants take asciminib for up to 2 years. The main goal is to see how many achieve a major molecular respons…

This Phase 2 trial tests whether adding venetoclax to a chemotherapy regimen of cladribine, low dose cytarabine, and azacitidine can improve remission rates in adults aged 50 and older with untreated acute myeloid leukemia. The study involves 145 participants and uses a two-stage…

This study is testing a new drug called ADI-PEG20, which breaks down arginine (a nutrient cancer cells need), together with two chemotherapy drugs (carboplatin and cabazitaxel) in men with aggressive variant prostate cancer. The goal is to find the safest dose and check for side …

This phase 2 trial is testing whether adding isatuximab to the standard drug lenalidomide after a stem cell transplant can better control high-risk multiple myeloma. About 61 adults aged 18 to 72 with newly diagnosed high-risk myeloma will receive the combination as maintenance t…

This study tests whether combining two drugs, blinatumomab and asciminib, can help control Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). The trial enrolls 40 adults who are not good candidates for strong chemotherapy. Researchers will monitor safety and…

This Phase 2 trial tests the drug asciminib in 50 adults newly diagnosed with chronic myeloid leukemia (CML). The goal is to see if asciminib can control the disease and to check for side effects. Participants take the drug by mouth, and researchers monitor their health closely.

This study tests a new treatment for people with blood cancers like leukemia, lymphoma, and multiple myeloma that have returned or not responded to treatment. Participants receive chemotherapy followed by specially engineered natural killer (NK) cells from donated cord blood. The…

This study tests whether adding the drug BMS-986504 to standard chemotherapy can help control pancreatic cancer in people with a specific genetic change (MTAP deletion). About 60 adults with this type of pancreatic cancer will receive the combination before and after surgery or w…

This phase 2 trial tests the drug AMB-05X in 15 colorectal cancer patients who have completed curative treatment but still have signs of cancer in their blood (ctDNA-positive) with no visible tumors on scans. The goal is to see if the drug can safely eliminate these remaining can…

This early-stage trial is testing whether combining chemotherapy and radiation, followed by more chemotherapy plus the immunotherapy drug dostarlimab, is safe and tolerable for people with stage IIIC node-positive endometrial cancer. The study aims to see if this approach can hel…

This study tests whether alternating two different drug combinations can help control higher-risk myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML). About 60 adults who have not responded to or relapsed after standard treatment will receive cladribine, low…

This study tests a new all-oral combination of three drugs—SNDX-5613, ASTX727, and venetoclax—for people with acute myeloid leukemia (AML) or related leukemia. The first part finds the safest dose of SNDX-5613, and the second part checks if that dose helps control the disease. Ab…

This study tests a drug called ivonescimab in 45 adults whose glioblastoma brain tumor has returned after standard treatment. Phase 1 finds the safest dose, and Phase 2 checks if that dose can control the tumor. The goal is to manage the disease, not cure it.

This phase 2 trial is testing a drug called zanidatamab in 20 people with early-stage, low-risk HER2-positive breast cancer. The drug is given intravenously, along with hormone therapy pills (letrozole or tamoxifen). The main goal is to see if the cancer disappears completely by …

This study tests a combination of two drugs, azacitidine (a standard chemotherapy) and APG1252 (a new targeted therapy), in people with high-risk acute myeloid leukemia (AML). The goal is to see if the combo is safe and can help control the disease. About 52 participants will be …

This study tests a device that uses nanosecond electrical pulses to destroy small papillary thyroid cancers (up to 1.5 cm) without cutting the skin. Fifteen participants will get the outpatient procedure under local anesthesia. The main goal is to check safety and side effects, n…

This phase 2 trial tests the drug zanzalintinib given before surgery in 45 people with advanced thyroid cancer. The goal is to see if the drug can shrink tumors, making surgery more effective. Researchers will also monitor safety and side effects.

This early-phase trial is testing a new drug called IACS-6274, either alone or combined with other cancer drugs, in 54 adults with advanced solid tumors (such as melanoma, ovarian, or head and neck cancers). The main goal is to find the safest dose and understand side effects. Th…

This study tests whether freezing only the part of the prostate that contains cancer (focal cryotherapy) can control intermediate-risk prostate cancer. About 30 men with a single area of cancer will receive this targeted treatment. The goal is to reduce side effects while keeping…

This study tests whether two drugs, fruquintinib and tislelizumab, can control leftover cancer cells in people with colorectal cancer who have completed chemotherapy but still show signs of minimal residual disease (MRD) on a blood test. About 20 adults with stable disease will r…

This study is testing a new procedure called nanosecond pulsed field ablation (nsPFA) to treat benign (non-cancerous) thyroid nodules. The goal is to see if this non-surgical treatment can shrink the nodules and improve patients' quality of life. The study will enroll 30 adults w…

This early-phase study is testing whether a new drug called SAR445877, when added to standard chemotherapy and a targeted therapy, is safe for people with advanced colorectal cancer that hasn't spread widely yet. About 41 adults will take part. The main goal is to find any side e…

This phase 1 trial is testing whether injecting tiny radioactive beads (Y-90) into the right side of the liver can shrink tumors and make the left side grow larger, so more patients with colorectal cancer liver metastases can have potentially curative surgery. The study will enro…

This early-stage trial is testing a drug called tasquinimod, either alone or with the standard drug ruxolitinib, in 33 people with myelofibrosis (a type of bone marrow cancer). The goal is to see if the combination is safe and can help control the disease, especially in patients …

This study tests whether the chemotherapy drug paclitaxel, given before and after stomach removal surgery, can improve outcomes for people with gastric cancer that has spread to the lining of the abdomen. About 30 adults with this condition will receive the drug and be monitored …

This study is for adults with high-risk soft tissue sarcoma that can be removed by surgery. It tests whether adding an immunotherapy drug (atezolizumab) to standard chemotherapy, radiation, and surgery can delay the cancer from coming back. About 50 participants will receive the …

This phase 2 trial tests whether giving patients their own personalized natural killer (NK) cells after chemotherapy and a cord blood transplant can help kill any remaining cancer cells. The study includes 100 people with various blood cancers like leukemia, lymphoma, and multipl…

This study tests a type of internal radiation called high-dose-rate brachytherapy for people with liver tumors that cannot be surgically removed. The treatment uses a tiny radioactive source placed directly into the tumor to kill cancer cells while sparing nearby healthy tissue. …

This phase 2 trial tests whether the drug belzutifan can control metastatic clear cell renal cell carcinoma in people who are currently just being watched (active surveillance). Researchers will compare belzutifan to continued observation in 78 adults with slow-growing disease wh…

This early-phase trial is testing whether people with stage II-III rectal cancer can safely avoid surgery by first receiving chemotherapy and then being closely monitored. The goal is to see if the rectum can be preserved without harming survival. Around 120 participants will be …

This study tests a drug called ivonescimab in 90 adults with advanced colorectal cancer that has already been treated. The drug is designed to help the immune system fight the cancer. Researchers want to see if it is safe and can control the disease.

This study tests a combination of three drugs—olutasidenib, decitabine, and venetoclax—in people with acute myeloid leukemia (AML) that has a specific IDH1 gene mutation. The goal is to find a safe and effective dose for those whose cancer has returned or not responded to treatme…

This phase II trial is testing whether adding two immunotherapy drugs (blinatumomab and inotuzumab ozogamicin) to a standard chemotherapy regimen (Hyper-CVAD) can improve outcomes for adults newly diagnosed with B-cell acute lymphoblastic leukemia (B-ALL). The study plans to enro…

This study tests a drug called canakinumab in people with low- or intermediate-risk myelodysplastic syndromes (MDS) or chronic myelomonocytic leukemia (CMML). The drug is a lab-made antibody that may help slow cancer growth and improve blood cell counts. About 76 adults will rece…

This phase 2 trial is testing whether adding the drug glofitamab after an initial treatment with acalabrutinib (or zanubrutinib) and rituximab can better control high-risk mantle cell lymphoma (MCL) in people who have not been treated before. The study will enroll 30 participants…

This early-stage trial is testing a chemotherapy drug called CPX-351 in people with high-risk myelodysplastic syndromes (MDS) or chronic myelomonocytic leukemia (CMML) that came back or didn't respond to standard treatment. The goal is to find the best dose that is safe and to se…

This study compares two drug combinations to prevent graft-versus-host disease (GVHD) in people aged 65 and older with certain blood cancers who receive a stem cell transplant. Participants will receive either cyclophosphamide, sirolimus, and MMF or cyclophosphamide, sirolimus, a…

This early-phase study tests a new treatment for people with advanced pancreatic cancer that has spread and has a specific mutation called KRAS G12D. The treatment uses tiny particles called exosomes to deliver a molecule that blocks the mutated gene. The goal is to find the best…

This early-stage trial tests a precise type of proton radiation for children with ependymoma, a brain tumor. The therapy is designed to kill cancer cells while reducing damage to healthy brain tissue. About 48 children will take part to see if the treatment is safe and what side …

This study tests a combination of two drugs, blinatumomab and ponatinib, along with standard chemotherapy, in people with a specific type of acute lymphoblastic leukemia (ALL) that has a genetic change called the Philadelphia chromosome. The goal is to see if this mix can better …

This study provides compassionate access to a device that selects CD34+ cells (special blood-forming cells) for patients whose stem cell transplant did not work well. The goal is to improve graft function and monitor for graft-versus-host disease. Up to 200 participants will rece…

This early-phase trial tests a new combination therapy for people with colorectal cancer who have minimal residual disease (MRD) — tiny amounts of cancer left after treatment. The approach uses specially engineered immune cells from cord blood (TROP2-CAR-NK cells) plus a targeted…

This early-phase trial is testing whether combining two drugs, naxitamab and sacituzumab govitecan, is safe and effective for people with metastatic triple-negative breast cancer. The study aims to find the best dose and check for side effects in 31 adults whose cancer has spread…

This phase 2 trial tests whether the drug olverembatinib can safely control chronic myeloid leukemia (CML) in people who are newly diagnosed. About 50 adults will take the drug by mouth. Researchers will track side effects and how well the drug works. The study is currently recru…

This study tests a combination of four drugs (mosunetuzumab, polatuzumab, tafasitamab, and lenalidomide) in people with relapsed B-cell non-Hodgkin lymphoma. The goal is to see if this mix can shrink tumors or stop the cancer from growing. About 36 adults who have already tried o…

This phase 2 trial tests whether the experimental drug SAR445877 can help control advanced non-small cell lung cancer in people whose tumors no longer respond to immunotherapy. About 29 adults with locally advanced or metastatic disease will receive the drug by IV. The main goal …

This study tests whether combining two chemotherapy drugs (tretinoin and arsenic trioxide) with a targeted therapy (gemtuzumab ozogamicin) works better than the two drugs alone for adults with a specific type of leukemia called acute promyelocytic leukemia. About 151 newly diagno…

This early-phase trial is testing whether adding a drug called eribulin to two standard chemotherapy drugs (irinotecan and temozolomide) is safe for children and young adults up to age 25 with solid tumors that have returned or not responded to treatment. The main goal is to find…

This phase 2 trial is testing whether the drug loncastuximab tesirine (Lonca) can help patients with large B-cell lymphoma who had only a partial response after CAR T-cell therapy achieve a complete remission. About 30 adults will receive Lonca as a consolidation treatment. The s…

This study tests a new treatment called KSQ-004EX for people with advanced solid tumors that have not responded to standard therapies. The treatment uses a patient's own immune cells (tumor infiltrating lymphocytes) that are genetically modified to be more powerful against cancer…

This early-stage study tests whether adding the HIV drug nelfinavir to standard chemotherapy (cisplatin) and radiation can safely treat advanced vulvar cancer that has spread and cannot be surgically removed. About 25 adults with stage II-IVA vulvar cancer will take part. The mai…

This study tests a combination of chemotherapy drugs (mini-Hyper-CVD) plus three targeted drugs (rituximab, inotuzumab ozogamicin, and blinatumomab) in children and young adults whose B-cell acute lymphocytic leukemia has come back or not responded to treatment. The goal is to se…

This phase 2 trial is testing whether adding the drug epcoritamab to a standard chemotherapy combination (R-miniCVP) can better control newly diagnosed diffuse large B-cell lymphoma in older or frail patients who cannot take strong chemotherapy. The study will enroll 40 adults an…

This Phase 2 trial is testing whether combining two drugs, tivozanib and nivolumab, can help control advanced non-clear cell kidney cancer. About 48 adults with this rare cancer type will receive the drugs to see how safe they are and whether they shrink or slow tumor growth. The…

This phase II trial is testing whether combining two drugs—CPX-351 (a chemotherapy) and venetoclax (a targeted therapy)—can help people with acute myeloid leukemia (AML) that has come back or not responded to prior treatment. About 52 adults will take part at MD Anderson Cancer C…

This study is testing a combination of oral medications for acute myeloid leukemia (AML) that has returned or not responded to treatment. The drugs include decitabine/cedazuridine, venetoclax, and either ivosidenib or enasidenib. The goal is to see if this combination is safe and…

This phase 2 trial is testing a combination of four chemotherapy drugs—cladribine, idarubicin, cytarabine, and venetoclax—in people with acute myeloid leukemia, high-risk myelodysplastic syndrome, or blast-phase chronic myeloid leukemia. The goal is to see if this mix can kill ca…

This early-phase trial is testing a new combination of three drugs—cyclophosphamide, axatilimab, and retifanlimab—in people with metastatic triple negative breast cancer that has stopped responding to standard treatments. The main goal is to find the safest dose of the new combin…

This phase 3 trial tests whether a multi-disciplinary treatment plan can help people with pancreatic cancer that has spread to only a few other places in the body live longer without the disease getting worse. About 80 adults with this condition will receive either standard care …

This study is testing whether shorter courses of radiation therapy can work as well as standard treatment for people with breast cancer that has spread to lymph nodes. About 768 participants who have had surgery will receive either a very short (ultrahypofractionated) or moderate…

This study tests whether a combination of three drugs—pembrolizumab, bevacizumab, and low-dose cyclophosphamide—can help control high-grade ovarian cancer that remains after standard frontline therapy. About 20 women with minimal residual disease will receive the treatment to see…

This study tests a drug called emapalumab to see if it can safely help people whose blood cell counts stay dangerously low after CAR T-cell therapy for certain lymphomas. About 32 adults who have already received standard CAR T-cell therapy will take part. The goal is to find out…

This study is testing whether a simple blood test that measures tumor DNA (ctDNA) can help doctors decide how much chemotherapy to give before surgery for colorectal or appendix cancer that has spread to the abdomen. The goal is to see if the test can identify patients who need s…

This phase II trial tests whether combining two drugs—azacitidine and pembrolizumab—can help people with Hodgkin's lymphoma that has come back or stopped responding to treatment. About 24 participants will receive both drugs by IV. The main goal is to see how many patients respon…

This early-phase study tests a new treatment called JV-213 for adults with B-cell lymphoma that has come back or not responded to other treatments. JV-213 uses the patient's own immune cells, modified to attack cancer cells. The main goal is to find the safest dose and monitor si…

This trial tests a new approach for people with multiple myeloma that has come back or not responded to treatment. Doctors take immune cells from donated cord blood, genetically engineer them to better recognize and attack myeloma cells, and give them back to the patient along wi…

This phase 2 trial is testing whether combining two immunotherapy drugs, nivolumab and relatlimab, can help control melanoma that has spread to the brain. About 30 adults with active brain metastases will receive the drugs by IV. Researchers will monitor side effects and how well…

This phase 2 trial tests brentuximab vedotin (Adcetris) in 55 patients with CD30+ malignant mesothelioma that cannot be removed by surgery. The drug is an antibody-drug conjugate designed to seek out and attack cancer cells carrying the CD30 marker. The main goal is to see if the…

This early-stage trial tests whether a specially engineered herpes virus (G207) is safe to inject directly into the brain tumors of children whose cancer has returned. Up to 24 children aged 3 to 21 will receive the virus, and some will also get a small dose of radiation to help …

This Phase 2 trial tests the drug ivonescimab in 40 people with advanced clear cell renal cell carcinoma that has worsened after prior treatment. The goal is to see if the drug can help control the cancer and to monitor any side effects. Participants receive ivonescimab by IV inf…

This study tests whether adding calcipotriene to the standard cream fluorouracil works better for people with multiple actinic keratoses (precancerous skin spots). Thirty adults will apply either fluorouracil alone for 2-3 weeks or a combination cream for just 4 days. Researchers…

This study tests an investigational drug called nirogacestat in about 40 adults with desmoid tumors (a type of non-cancerous growth). The main goal is to check the drug's safety and side effects. Researchers will also see how the tumor responds to treatment.

This study tests whether adding a third drug (relatlimab) to a standard two-drug combination (nivolumab and ipilimumab) works better for advanced kidney cancer that hasn't been treated before. About 15 adults with stage IV clear cell kidney cancer will receive either the three-dr…

This early-phase trial tests a new treatment made from specially engineered cord blood cells (TROP2-CAR-NK cells) in adults with advanced solid tumors that have not responded to standard therapies. The main goal is to find a safe dose and monitor side effects. Up to 54 participan…

This early-phase trial tests a new two-drug combination for men with metastatic castration-resistant prostate cancer that has progressed after at least two prior treatments. The drugs are REGN5678, which helps immune cells target cancer cells, and cemiplimab, which removes the br…

This early-phase trial is testing whether a combination of two drugs, atezolizumab and tiragolumab, can help control bladder cancer when given before surgery to remove the bladder and tumor. The study includes 10 adults with muscle-invasive bladder cancer who cannot take standard…

This phase II trial is testing a drug called puxitatug samrotecan (AZD8205) in 28 adults with an aggressive form of adenoid cystic carcinoma that has spread or come back. The study aims to see if the drug is safe and effective for this specific cancer subtype. Participants will r…

This study tests a new type of immune cell therapy for people with myeloid cancers (like AML or MDS) that have come back or not responded to treatment. The cells are taken from donated cord blood, engineered to better recognize and attack cancer cells, and given after chemotherap…

This study tests a drug called REGN5678 in men with high-risk prostate cancer who will later have their prostate removed. The goal is to check the drug's safety and how it affects the cancer before surgery. About 42 men will take part in this early-phase trial at MD Anderson Canc…

This study tests a combination of three drugs (177Lu girentuximab, cabozantinib, and nivolumab) in people with advanced clear cell kidney cancer who have not had prior treatment. The goal is to see if the combination can control the cancer and to check for side effects. About 100…

This Phase 2 trial is testing whether a CAR T-cell therapy called obecabtagene autoleucel (obe-cel) can help control newly diagnosed, high-risk B-cell acute lymphoblastic leukemia (ALL) after initial treatment. The study will enroll 30 adults with high-risk features who are in fi…

This early study tests whether adding special cells from donated umbilical cord blood (called mesenchymal stromal cells) to the drug ruxolitinib can help control severe graft-versus-host disease (GVHD) that hasn't improved with steroids. GVHD is a serious complication where donor…

This study tests whether having a partner for support helps inactive women increase their physical activity. 500 women aged 18-65 who are not very active will be paired with a female partner. They will use activity trackers, get educational newsletters, and receive phone coaching…

This study is testing whether giving radiation therapy along with immunotherapy before surgery can improve outcomes for people with sinonasal or anorectal mucosal melanoma, two rare and aggressive cancers. About 40 participants will receive combination immunotherapy (such as ipil…

This study tests whether combining two oral drugs, pirtobrutinib and venetoclax, can control mantle cell lymphoma (MCL) in patients whose cancer has come back or hasn't responded to prior treatments. About 30 adults with confirmed MCL will take these pills to see how many achieve…

This study tests whether matching smoking cessation treatments—like nicotine patches, counseling, or medications—to a person's unique traits can help them quit. About 2,010 smokers who want to quit will receive personalized care. The goal is to find better ways to help people sto…

This early-phase study tests the safety of an engineered virus called M032 in 20 children and adults with diffuse midline glioma, a rare and aggressive brain tumor. Participants receive the virus directly into the tumor after completing standard radiation therapy. The goal is to …

This early-phase trial tests a new treatment called Attil12-T cell therapy for people with advanced soft tissue or bone sarcoma that has spread or cannot be removed. The therapy uses a patient's own immune cells, modified to target and attack the tumor. The main goals are to find…

This phase 2 trial is testing whether combining a CAR T-cell therapy (axicabtagene ciloleucel) with radiation therapy is safe for people with follicular lymphoma that has returned or not responded to at least two prior treatments. About 20 adults will receive the treatment, and r…

This phase 2 trial tests whether adding local treatments (like radiation or surgery) to the drug lorlatinib can better control advanced ALK-positive non-small cell lung cancer. About 30 patients who have not had prior targeted therapy will receive lorlatinib for 12 weeks, then ma…

This study tests whether a special type of immune cell (ONC-PluReceptor NK cells) given with two antibody drugs (epcoritamab and tafasitamab) can control B-cell Non-Hodgkin lymphoma that has come back or not responded to prior treatments. About 30 adults aged 18-80 who have alrea…

This study tests whether a time-limited combination of three drugs (pirtobrutinib, venetoclax, and obinutuzumab) is safe and effective for people with untreated chronic lymphocytic leukemia (CLL) or Richter transformation (RT). About 60 adults with good organ function and perform…

This early-phase study tests a new treatment for advanced clear cell kidney cancer that has stopped responding to standard therapies. The treatment uses donor immune cells (NK cells) that are genetically modified to better recognize and attack cancer cells while resisting the tum…

This phase 2 trial tests an optimized cord blood transplant for 35 patients with high-risk blood cancers (like leukemia) who relapsed after their first stem cell transplant. Participants receive chemotherapy followed by a cord blood infusion, plus drugs to prevent rejection. The …

This early-phase study tests a combination of three drugs (decitabine, lisaftoclax, and olverembatinib) in 30 adults with advanced chronic myeloid leukemia or a related acute leukemia. The goal is to find safe doses and see if the combo can control the disease in people who have …

This study tests a CAR T-cell drug called brexucabtagene autoleucel in 40 adults with B-cell acute lymphocytic leukemia that has come back or is hard to treat. Participants first receive standard chemotherapy drugs to reduce cancer, then get the CAR T-cells. The goal is to see if…

This Phase 2 trial is testing whether a combination of two drugs, pirtobrutinib and rituximab, can help people with untreated low or intermediate risk mantle cell lymphoma achieve long-term remission without chemotherapy. The study will enroll 50 adults who have not received prio…

This phase 2 trial tests whether adding metal detoxification drugs (DMSA and Ca-EDTA) to standard therapy can improve outcomes for adults with intermediate- to high-risk acute myeloid leukemia (AML). Researchers believe lowering metal levels in blood and bone marrow may help cont…

This early-phase trial tests a new treatment for colorectal cancer that has spread to the lining of the abdomen. It combines specially engineered natural killer (NK) cells, given both into a vein and directly into the belly, with the drug cetuximab. The goal is to find the safest…

This early-stage study is testing the safety of two devices (NovoTTF-200M and NovoTTF-200A) that deliver electric fields to treat spinal tumors that have not responded to standard treatments like surgery or radiation. About 30 participants will receive the treatment, either alone…

This study tests two drugs, atezolizumab and cabozantinib, in 40 adolescents and young adults (ages 12 and up) with osteosarcoma that has come back or spread. Atezolizumab helps the immune system attack cancer cells, while cabozantinib blocks enzymes that help tumors grow. The go…

This study tests whether two drugs, zanzalintinib and pembrolizumab, can help control advanced soft-tissue sarcoma that has spread. About 20 adults with specific sarcoma types will receive the combination. The main goal is to check safety and see if the treatment slows tumor grow…

This study tests a new, more precise way to perform liver ablation (using heat or cold to destroy tumors) in people with liver cancer. The technique combines stereotactic guidance, special CT imaging, and computer software to ensure the entire tumor is treated. About 50 participa…

This study is for people with esophageal or stomach cancer that has spread to 3 or fewer places in the body. It compares standard chemotherapy alone to chemotherapy plus radiation or surgery to the main tumor and those spots. The goal is to see if adding local treatment helps peo…

This study tests whether radiofrequency ablation (using heat to destroy tumors) can safely lower high calcium levels in 20 adults with recurrent parathyroid cancer who cannot have surgery. Participants will have one to five neck tumors treated. The goal is to control the disease …

This phase 2 trial is testing whether a combination of three drugs—acalabrutinib, venetoclax, and obinutuzumab—can better control chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) that has come back or is resistant to treatment. About 168 adults with high-ri…

This early-phase study tests a new type of cell therapy for people with advanced melanoma that has not responded to standard treatments. The therapy uses a patient's own immune cells (NK cells) that are engineered in the lab to recognize and attack a protein called PRAME found on…

This phase II trial tests whether ultra low dose radiation can control skin lesions in people with mycosis fungoides, a type of lymphoma. About 50 participants will receive very low doses of radiation to their skin lesions. The goal is to see if this gentler approach works as wel…

This study is for people with certain blood cancers (like acute myeloid leukemia) that have a specific genetic change called a FLT3 mutation. The cancers have either come back or not responded to prior treatment. The trial tests a combination of three drugs—azacitidine, venetocla…

This early-phase trial tests a new therapy for people with advanced synovial sarcoma or myxoid/round cell liposarcoma. Participants receive donated natural killer (NK) cells that have been engineered to recognize and attack a protein called NY-ESO-1 found on their cancer cells. T…

This early-phase trial is testing a new type of radiation called HYDRA for people with laryngeal cancer. The goal is to find the highest safe dose and see how well it controls the tumor. Eleven participants will receive different doses of radiation and complete quality-of-life su…

This early-phase study is testing two drugs together — alpelisib and pembrolizumab — in people with metastatic breast cancer or melanoma that has spread to the brain or other organs. The main goal is to find a safe dose and see what side effects occur. Up to 50 adults whose cance…

This study tests an oral drug called larotrectinib in people aged 16 and older whose advanced solid tumors have too many copies of the NTRK gene. The drug blocks enzymes that help cancer cells grow. Researchers will measure how many patients' tumors shrink or disappear.

This phase 2 trial tests a cream containing tofacitinib, a drug that calms the immune system, for people with early-stage cutaneous T-cell lymphoma (CTCL). The study will include 20 adults with stage IA, IB, or IIA disease. Researchers want to see if the cream is safe and can hel…

This study tests an oral drug called ONC201 in people whose acute leukemia or high-risk myelodysplastic syndrome (MDS) has returned or not responded to standard treatments. The trial has two phases: Phase I finds the safest dose, and Phase II checks if the drug shrinks or control…

This study tests whether fecal microbiota transplantation (FMT) can reduce gut-related side effects from antibiotics in 40 adults with B-cell lymphoma who are receiving standard CAR-T cell therapy. Participants will receive FMT alongside their cancer treatment to see if it improv…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy (gemcitabine and cisplatin) before and after surgery can improve outcomes for people with a type of bile duct cancer called intrahepatic cholangiocarcinoma. The trial will enroll 24 adul…

This early-phase trial is testing a new treatment for autoimmune disorders like lupus and scleroderma. It combines specially engineered natural killer cells (AD-PluReceptor) with a drug called tafasitamab and chemotherapy to try to control the disease. The study will enroll 47 pe…

This phase 2 trial is testing whether adding the antibiotic metronidazole to standard therapy can reduce harmful bacteria (F. nucleatum) in rectal cancer patients. About 60 adults with locally advanced rectal cancer will receive either standard treatment plus metronidazole or sta…

This phase II trial is testing two oral drugs, binimetinib and encorafenib, in 35 adults with advanced melanoma that has spread to the brain. The drugs block enzymes that help cancer cells grow. The study aims to see if this combination can control the disease and improve surviva…

This phase 2 trial tests a drug called olutasidenib combined with other targeted therapies for people with relapsed or hard-to-treat blood cancers that have a specific IDH1 mutation plus other signaling mutations. The study aims to see how safe and tolerable these drug combinatio…

This study tests whether adding low-dose radiation to the drug elranatamab can better kill cancer cells in people with multiple myeloma that has come back or not responded to treatment and has spread outside the bone. About 34 adults will receive the combination. The goal is to s…

This phase 2 trial tests whether combining surgery to remove visible tumor with heated chemotherapy delivered directly into the abdomen can help women whose mucinous ovarian cancer has returned. About 30 participants will receive this intensive treatment. The goal is to see how l…

This study tests whether two drugs, pembrolizumab and lenvatinib, can shrink brain tumors in people with breast cancer, lung cancer, or other solid tumors that have spread to the brain. About 87 participants will receive the combination therapy. The goal is to see how well the tr…

This study tests whether radiation therapy can help control multiple myeloma that remains active after standard CAR-T cell therapy. About 30 adults who still have signs of myeloma on scans after CAR-T will receive targeted radiation to up to five tumor spots. Researchers will mea…

This study tests a new treatment plan for people with a rare and aggressive blood cancer called BPDCN. The plan combines two targeted drugs (tagraxofusp and venetoclax) with standard chemotherapy to kill cancer cells. The goal is to see if this combination can control the disease…

This phase 2 trial is testing whether giving systemic therapy first, followed by focused radiation (stereotactic radiosurgery), can better control brain metastases. About 316 adults with brain metastases that are low-risk will receive standard cancer drugs, then some will get rad…

This early-stage trial tests a new drug called CBP-1019 combined with standard chemotherapy (FOLFOX) and possibly other drugs for people with advanced solid tumors that have not responded to prior treatments. The goal is to find safe and effective doses. About 128 participants wi…

This early-stage trial is testing whether genetically modified T-cells can safely control viral infections in cancer patients with weakened immune systems. The T-cells are designed to target specific viruses like CMV, BK virus, or COVID-19. The study involves 30 participants and …

This early-phase trial tests a new drug called NBTXR3, which is injected into the tumor and activated by radiation to destroy cancer cells. It is given alongside standard chemotherapy for people with stage II–III esophageal adenocarcinoma. The main goals are to find the safest do…

This study tests whether two drugs, venetoclax and revumenib, can control minimal residual disease (MRD) in people with acute myeloid leukemia (AML). MRD means small numbers of cancer cells remain after initial treatment, raising the risk of relapse. The trial enrolls about 8 par…

This phase 2 trial is testing whether a combination of three drugs—nivolumab, ipilimumab, and cabozantinib—can help people with kidney cancer that has spread to the brain. The study will enroll 20 participants who have not had prior treatment for their brain metastases. The main …

This Phase 3 trial tests whether adding chemotherapy (cisplatin and etoposide) to the standard drug mitotane after surgery works better than mitotane alone for patients with adrenocortical carcinoma at high risk of recurrence. The study plans to enroll 240 adults with stage I-III…

This study tests a drug called NBTXR3 given with radiation therapy for people with locally-advanced non-small cell lung cancer who cannot have chemotherapy or surgery. The goal is to see if the combination is safe and helps control the cancer. About 40 adults with stage I to III …

This early-phase trial is testing whether adding an experimental drug called HC-7366 to standard immunotherapy drugs (nivolumab and ipilimumab) can help control advanced clear cell kidney cancer. About 35 adults with stage IV disease will receive the combination. The main goal is…

This phase 2 trial is testing a combination of five drugs (fludarabine, cytarabine, filgrastim-sndz, gemtuzumab ozogamicin, and idarubicin) in 270 people with newly diagnosed acute myeloid leukemia or high-risk myelodysplastic syndrome that have specific genetic changes. The goal…

This phase 2 trial tests whether the drug sacituzumab govitecan can help control salivary gland cancer that has come back or spread to other parts of the body. About 30 adults whose cancer cannot be removed by surgery or cured with radiation will receive the drug through an IV. R…

This early-stage trial tests whether a stool transplant (FMT) can help cancer patients who develop severe diarrhea or colon inflammation from immune-checkpoint inhibitor drugs. About 40 patients with various cancers will receive the transplant via colonoscopy. The main goal is to…

This phase 2 trial tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy can shrink advanced squamous cell cancers of the nasal cavity and sinuses better than chemotherapy alone. About 35 adults with newly diagnosed, untreated stage II to IVb disease …

This study tests whether a combination of three drugs—calaspargase pegol-mknl, decitabine, and venetoclax—can help control relapsed or treatment-resistant T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LLy) in patients aged 1 month to 21 years. T…

This early-phase trial tests the safety and best dose of a drug called ulixertinib when given with cetuximab and/or encorafenib. It is for people with advanced colorectal cancer that has spread and who have already tried treatments targeting EGFR or BRAF. The goal is to find a do…

This early-phase trial is testing an oral drug called NP-101 in 35 adults with advanced solid tumors that have not responded to standard treatments. The main goal is to check safety and side effects, with a secondary look at whether the drug can shrink tumors. Because it is a Pha…

This study looks at whether adding radiation to the liver can improve outcomes for people with advanced intrahepatic cholangiocarcinoma, a type of bile duct cancer that has spread. About 60 adults with at least one liver tumor 3 cm or larger will receive either standard therapy a…

This early-phase trial is testing whether combining the drug talazoparib with one of three other drugs (palbociclib, axitinib, or crizotinib) can safely help control advanced solid tumors that have spread. Talazoparib blocks cancer cells from repairing their DNA, while the other …

This study tests whether giving high-dose ruxolitinib and busulfan before a stem cell transplant can reduce spleen size and help the transplant work better in people with myelofibrosis. About 30 adults aged 18 to 75 with an enlarged spleen and a matched donor will take part. The …

This study tests a combination of three drugs—ivosidenib, venetoclax, and azacitidine—in people with blood cancers like acute myeloid leukemia (AML) that have a specific IDH1 mutation. The goal is to see if the combo is safe and works better than current treatments. About 96 adul…

This early-phase trial is testing the drug talazoparib together with radiation therapy in 24 women whose gynecologic cancer (ovarian, endometrial, cervical, or related cancers) has come back after previous treatment. Talazoparib blocks enzymes that cancer cells need to grow, and …

This study is for people with certain types of breast cancer (HER2-positive or triple-negative) who have a complete response to initial drug therapy. It tests whether they can safely skip surgery and only receive radiation, or skip radiation if surgery shows no cancer left. For a…

This study tests whether a family-centered program can help Black prostate cancer survivors and their caregivers eat better, be more active, and feel better overall. About 648 survivor-caregiver pairs will join, with some receiving the family program, some the survivor-only progr…

This study tests a new way to give radiation therapy for advanced prostate cancer. Instead of many sessions, patients get just 5 high-dose treatments. The goal is to see if this shorter approach is safe and works well. About 70 people with high-risk prostate cancer will take part…

This early-phase trial tests a new drug called nadunolimab combined with standard treatments (azacitidine, with or without venetoclax) in 40 adults with high-risk myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). The goal is to see if the combination is safe and to …

This study tests a drug called ponatinib in 50 adults with chronic myeloid leukemia (CML) whose cancer did not respond to or they could not tolerate other targeted therapies. The goal is to see if ponatinib can control the disease by blocking a protein that helps cancer cells gro…

This study is for people whose brain metastases have returned after initial radiation. It combines either laser ablation or surgery with a second round of targeted radiation. The goal is to control the disease and monitor side effects in 155 participants.

This study tests a drug called olutasidenib in people with certain early blood conditions (CCUS, lower-risk MDS, or CMML) that have a specific IDH1 gene change. The goal is to see if the drug can control the disease and is safe. About 15 participants will take the drug and be mon…

This study tests whether adding belantamab mafodotin to lenalidomide after a stem cell transplant can turn residual myeloma cells undetectable in patients with newly diagnosed multiple myeloma. About 94 adults who have already had a transplant will receive the combination therapy…

This study tests whether a non-invasive ventilation mask (NIPPV) can reduce the need for intubation in cancer patients with respiratory failure. Researchers will compare NIPPV plus standard oxygen therapy to standard oxygen therapy alone in 256 participants. The goal is to see if…

This study tests whether adding the drug venetoclax to standard chemotherapy can better treat acute myeloid leukemia (AML) that is newly diagnosed or has come back. About 116 adults with AML or high-risk MDS will receive the combination. The goal is to see if the combo improves r…

This early-phase trial is testing whether combining an immunotherapy drug (nivolumab) with chemotherapy (fluorouracil) and an immune stimulant (interferon alpha 2b) can safely shrink or control fibrolamellar liver cancer that cannot be removed by surgery. The study will enroll 15…

This early-phase trial tests a modified cold virus (DNX-2401) that is loaded into donor stem cells and injected into the brain's blood supply to target recurrent high-grade gliomas. The virus is designed to infect and kill cancer cells while leaving healthy cells alone. The study…

This phase II study is testing a combination of two drugs, enasidenib and azacitidine, in people with acute myeloid leukemia (AML) that has come back or not responded to treatment. The trial enrolls 50 adults with a specific IDH2 gene mutation. The goal is to see if the combinati…

This phase 2 trial is testing whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard chemotherapy (carboplatin and paclitaxel) can improve outcomes for people with stage 1 triple-negative breast cancer. The study will enroll 28 participants at MD Anderson Canc…

This study tests a new treatment using specially engineered immune cells (called CAR-NK cells) from donated cord blood, given alongside chemotherapy, for people with advanced kidney cancer, mesothelioma, or bone cancer. The goal is to find a safe dose and see if it helps control …

This study tests whether adding celecoxib to TAS-102 can clear tiny amounts of cancer DNA (ctDNA) in the blood of colorectal cancer patients who have finished standard chemotherapy. About 25 adults with stage II-IV colorectal cancer and no visible tumors on scans will take TAS-10…

This phase 2 trial tests whether adding cediranib or ceralasertib to olaparib can overcome resistance in BRCA-mutated advanced breast cancer. About 60 participants with HER2-negative, BRCA-positive tumors that have progressed on prior therapy will receive one of the two drug comb…

This study compares two surgical approaches for people with advanced ovarian, fallopian tube, or primary peritoneal cancer who have received chemotherapy before surgery. One group will have minimally invasive surgery (small incisions), and the other will have standard open surger…

This study tests a daily pill called olutasidenib given after a stem cell transplant to people with certain blood cancers (like AML or MDS) that have an IDH1 mutation. The goal is to see if the drug is safe and tolerable as maintenance therapy. About 31 participants will take the…

This study tests if injecting the cancer drug nivolumab directly into high-risk precancerous mouth lesions can stop them from turning into cancer. About 45 adults with these lesions will receive either the drug or a placebo injection. The goal is to see if the treatment is safe a…

This early-stage trial is testing whether two drugs that lower metal levels in the body can help people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) respond better to chemotherapy. The study will enroll 58 adults and aims to find the safest dose and check f…

This early-phase study tests a new treatment called JV-394 for people with T/NK cell lymphoma that has come back or not responded to standard therapy. JV-394 is made from a patient's own immune cells, which are modified to attack cancer cells. The main goal is to find a safe dose…

This early-phase trial tests a new treatment called attIL12-TIL for people with advanced or metastatic soft tissue and bone sarcoma. The therapy uses a patient's own tumor-fighting immune cells, modified to better target and attack cancer. The study first finds a safe dose, then …

This early-phase trial is testing a combination of two drugs, gemcitabine and nab-sirolimus, in people with advanced leiomyosarcomas or soft-tissue sarcomas that have lost function in the TSC1 or TSC2 genes. The main goal is to find a safe and tolerable dose. The study plans to e…

This early-phase study tests a combination of two drugs (BMS-986504 and olaparib) in adults with advanced solid tumors that have lost a gene called MTAP. The main goal is to find safe doses and understand side effects. About 36 people will take part, and the study is currently re…

This study tests if the drug elranatamab, given before and after a stem cell transplant, can better control high-risk multiple myeloma. About 40 adults with newly diagnosed, high-risk disease will receive the drug to reduce cancer cells before transplant and then as maintenance t…

This study tests a combination of targeted drugs and immunotherapy for people with untreated primary mediastinal large B-cell lymphoma (PMBL), a rare type of blood cancer. The treatment uses brentuximab vedotin (which delivers a toxin directly to cancer cells) and nivolumab (whic…

This early-phase study tests a new drug called rezatapopt combined with the standard drug azacitidine in 24 adults with a specific type of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that has a TP53Y220C mutation. The main goal is to check safety and find the b…

This study is for people with multiple myeloma that has come back or stopped responding to other treatments. The trial has two parts: first, finding the best dose of a drug called belumosudil mesylate, and second, testing that dose alone or with dexamethasone to see if it can con…

This phase 2 trial is testing whether adding the targeted drug golidocitinib to standard chemotherapy (CHOP) can better control newly diagnosed peripheral T cell lymphoma, a rare and aggressive blood cancer. About 30 adults will receive the combination, and researchers will monit…

This study is testing whether crushing belumosudil tablets and mixing them with water changes how the drug is absorbed in people with chronic graft-versus-host disease (cGVHD). Only 8 participants who have had a stem cell transplant will take the drug both ways and have their blo…

This phase II trial is testing a combination of six chemotherapy drugs (clofarabine, etoposide, cyclophosphamide, liposomal vincristine, dexamethasone, and bortezomib) in patients with acute lymphoblastic leukemia, lymphoblastic lymphoma, or related cancers that have come back or…

This clinical trial is testing whether adding the drug venetoclax to standard chemotherapy before a stem cell transplant can improve outcomes for people with high-risk acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The study will enroll 324 participants and aims …

This early-stage trial tests whether specially grown donor T cells can safely treat adenovirus infections in people with weakened immune systems, such as cancer patients. The cells are designed to target and kill the virus. The study will check for side effects and see if the inf…

This phase II trial tests whether adding local treatments like surgery or radiation to the immunotherapy drug durvalumab can help control stage III non-small cell lung cancer that has progressed after chemoradiation and durvalumab. About 51 participants with 3 or more growing tum…

This study tests a combination of two drugs, azacitidine and enasidenib, in people with a high-risk blood cancer called myelodysplastic syndrome (MDS) that has a specific genetic change (IDH2 mutation). The goal is to see if the drugs can stop cancer growth and improve outcomes. …

This study tests whether adding ASTX727 to the standard drug dasatinib can better control chronic myeloid leukemia (CML) in newly diagnosed patients. About 70 adults with a specific genetic marker (Philadelphia chromosome) will receive both pills. The goal is to see if the combin…

This study tests a drug called revumenib in 40 people with leukemia that has come back or not responded to treatment. The leukemia must have certain genetic changes that turn on HOX genes. The goal is to see if revumenib can safely control the disease. Participants take the drug …

This study looks at whether giving radiation to the lymph nodes after surgery can lower the chance of melanoma returning in people who are already receiving immunotherapy. About 168 adults with high-risk melanoma that has spread to a sentinel lymph node will take part. The goal i…

This phase 2 trial tests whether combining two antiviral drugs, baloxavir and oseltamivir, works better than oseltamivir alone for severe flu in people with weakened immune systems (such as blood cancer patients or stem cell transplant recipients). The study will measure how quic…

This early-stage trial tests two oral drugs, ziftomenib and quizartinib, together in adults with relapsed or hard-to-treat acute myeloid leukemia (AML) that has certain genetic markers. The goal is to find a safe and effective all-pill treatment for common AML subtypes. About 44 …

This phase 2 trial tests whether pravastatin (a cholesterol drug) or a combination of pentoxifylline and vitamin E can prevent lymphedema and fibrosis (swelling and scarring) caused by radiation therapy in head and neck cancer patients. About 295 adults with oropharyngeal cancer …

This phase I/II trial tests whether injecting NBTXR3 nanoparticles into tumors can make radiation more effective, combined with immunotherapy (anti-PD-1/PD-L1), for patients with advanced solid cancers that have spread to the lung or liver. The study aims to see if this approach …

This study tests whether a blood test that detects tiny bits of tumor DNA (ctDNA) after liver surgery can help doctors decide who needs more chemotherapy. About 120 adults with colorectal cancer that spread to the liver will have their ctDNA levels checked after surgery. Those wi…

This study tests whether combining two drugs, niraparib and dostarlimab, can control advanced cancers that have spread to the brain. It includes 120 adults with certain cancer types like BRCA-mutated or lung cancers. The goal is to see if the treatment shrinks or stabilizes brain…

This Phase 2 trial tests whether combining cladribine, low-dose cytarabine, and decitabine can help control acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS). About 160 older adults (60+) who haven't had prior intensive treatment will receive the drugs in c…

This study tests whether adding a prebiotic-rich diet to standard immunotherapy before surgery can improve immune response in people with melanoma. About 35 adults with resectable melanoma will receive prebiotic snack packs and diet counseling alongside their usual treatment. The…

This study tests a new treatment using immune cells (NK cells) from donated cord blood that are engineered to target a protein called CD5 found on certain cancer cells. The treatment is given after chemotherapy to prepare the body, and the goal is to see if it is safe and effecti…

This early-phase trial is testing the safety of the immunotherapy drug pembrolizumab (Keytruda) in 37 people with thymoma or thymic carcinoma that cannot be removed by surgery. The drug helps the immune system attack cancer cells. Researchers are looking at side effects and how w…

This phase 1 study is testing a combination of three drugs—ziftomenib, venetoclax, and azacitidine—in children and young adults (ages 2 to 21) with acute leukemia that has returned or not responded to treatment. The main goal is to find the safest dose of ziftomenib when given wi…

This phase 2 trial tests several medications—including pravastatin, pentoxifylline, and others—to see if they can treat or prevent lymphedema and fibrosis caused by radiation therapy in head and neck cancer survivors. About 250 participants who have finished radiation at least 6 …

This early-stage trial tests genetically engineered natural killer (NK) cells in 25 people with recurrent glioblastoma, an aggressive brain cancer. The cells are designed to resist the tumor's defenses. The main goal is to find a safe dose and check for side effects, while also w…

This phase 2 trial tests whether two drugs, tucatinib and T-DM1, can control HER2-positive solid tumors that have spread to the brain. About 30 participants will receive both drugs, and researchers will monitor side effects and how well the treatment works. The goal is to find a …

This study tests whether the drug letermovir can prevent cytomegalovirus (CMV) from reactivating in people who have received a type of CAR T-cell therapy called axicabtagene ciloleucel. CMV is a common virus that can cause serious illness when the immune system is weakened. The t…

This study tests whether combining two drugs, mosunetuzumab and zanubrutinib, can safely control marginal zone lymphoma that has returned or stopped responding to prior treatment. About 36 adults with stage II–IV disease will receive the combination. The goal is to see how well t…

This early-phase trial tests whether adding an experimental drug called CTX-009 to standard chemotherapy (gemcitabine and cisplatin) plus immunotherapy (durvalumab) can safely treat advanced biliary tract cancer that cannot be removed by surgery. About 50 adults will receive the …

This early-phase trial tests whether adding the drug lurbinectedin to two standard chemotherapy drugs (paclitaxel and bevacizumab) can better control platinum-resistant ovarian cancer. About 34 adults with advanced ovarian, fallopian tube, or peritoneal cancer will receive the co…

This early-phase trial tests a wearable device that creates electric fields (tumor treating fields) combined with either cabozantinib or nab-paclitaxel and atezolizumab in 43 people with advanced solid tumors in the abdomen or chest. The goal is to find the safest dose and see if…

This phase 1 trial tests an oral chemotherapy drug (decitabine) alone or combined with other targeted drugs to prevent acute myeloid leukemia (AML) from coming back in patients who are already in remission. About 125 adults whose AML is under control but who are not ready for a s…

This study tests whether inhaling a drug called tranexamic acid can help stop lung bleeding in cancer patients who are on breathing machines. The trial includes 60 adults with blood cancers and severe lung bleeding. Half will get the inhaled drug plus usual care, and half will ge…

This study tests a more intense treatment for a fast-growing type of brain cancer called IDH wildtype glioma. It combines higher doses of radiation with the chemotherapy drug temozolomide to try to stop the tumor from growing longer. The trial will enroll 40 adults with this spec…

This phase II trial is testing whether a shorter course of higher-dose radiation (hypofractionated) can effectively treat Merkel cell carcinoma, a rare skin cancer. The study aims to see if this approach controls the tumor and nearby lymph nodes for at least two years, while bein…

This study tests whether adding 1 year of pembrolizumab (an immunotherapy drug) after radiation therapy can better control kidney cancer that has spread to a few spots. About 144 people with this type of cancer will take part. The main goal is to see if the combination is safe an…

This study tests whether combining three drugs—pemigatinib, atezolizumab, and bevacizumab—can help control advanced bile duct cancer that has a specific genetic change (FGFR2 fusion). About 25 adults whose cancer has not responded to other treatments will take part. The main goal…

This study tests a combination of ultra-low-dose radiation to the whole skin and a drug called brentuximab vedotin for people with mycosis fungoides, a rare type of skin lymphoma. The treatment is given every three months for a year. The goal is to see if this approach can better…

This study is testing a combination of three drugs—quizartinib, decitabine, and venetoclax—in people with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome. The goal is to find the safest dose and see if the combination improves remission rates. The trial is for …

This study tests the safety and best dose of bendamustine, given with or without cyclophosphamide, to prevent graft-versus-host disease (GVHD) in people with blood cancers receiving a stem cell transplant. About 25 participants will receive the drug after transplant, along with s…

This study tests a chemotherapy drug called paclitaxel, given directly into the abdominal cavity, for people with appendix cancer that has spread. The goal is to find a safe dose and see if it helps control the disease. About 39 adults with advanced appendix cancer that cannot be…

This study tracks 150 gastrointestinal cancer patients with a narrowed portal vein who receive a stent to keep the vein open. Researchers will monitor how long the stent stays clear, changes in liver function, nutrition, bleeding risk, and quality of life. The goal is to see if s…

This early-phase trial is testing whether combining two drugs—pembrolizumab (an immunotherapy that helps the immune system attack cancer) and lenvatinib (which blocks enzymes that help tumors grow)—can shrink tumors in people with advanced stomach or gastroesophageal cancer that …

This study tests whether a very low dose of radiation (4 Gy) can control marginal zone lymphoma, a slow-growing blood cancer. Participants first get the low dose, and if needed, a higher dose later. The goal is to see if this approach works with fewer side effects. About 50 adult…

This phase II trial is testing a combination of chemotherapy drugs plus nelarabine in 160 people with previously untreated T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma. The goal is to see if this stronger cocktail can improve remission rates and help people live …

This early-stage trial is testing whether stem cells from a donor can help control heart failure in people whose hearts were weakened by a type of chemotherapy called anthracyclines. About 72 participants will either receive standard care alone or standard care plus stem cells gi…

This study tests two drugs—axatilimab and ruxolitinib—together in people with myelofibrosis or chronic myelomonocytic leukemia. The goal is to find a safe dose and see if the combination helps control the disease. About 66 adults who have tried other treatments or are new to ther…

This study is for people with high-risk chronic lymphocytic leukemia (CLL) who have been on ibrutinib or acalabrutinib for at least a year but still have detectable disease. Researchers want to see if adding venetoclax for 12 cycles can clear remaining leukemia cells from the bon…

This study tests whether a combination of three drugs—pirtobrutinib, venetoclax, and obinutuzumab—can control relapsed chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). About 40 adults who have had prior treatment will receive this time-limited therapy. The …

This phase III trial tests whether giving focused radiation before surgery for brain metastases works better than giving it after surgery. The study involves 180 patients with cancer that has spread to the brain. Researchers will compare how well each approach controls the diseas…

This study is testing whether a new contrast agent called gadopiclenol (VUEWAY) can improve MRI scans to detect leptomeningeal disease (LMD), a condition where cancer spreads to the lining of the brain and spinal cord. Researchers will compare it to the standard contrast agent ga…

This study tests whether advanced MRI and CT scans can tell the difference between a brain tumor that is actually growing (true progression) and one that only looks like it is growing after treatment (pseudoprogression). About 25 adults who have had brain tumor treatment and now …

This study is testing a mixed meal test to better diagnose a specific type of diabetes (type 3c) that occurs in people with pancreatic cancer or chronic pancreatitis. Researchers will enroll 775 adults aged 30 to 84 who have new-onset diabetes and one of these pancreatic conditio…

This early-stage study tests a new imaging agent called 18F-4FN for PET scans to safely detect inflammation in the body. It involves 55 adults with cancer who are on immunotherapy or have suspected inflammation. The goal is to see if this agent can highlight areas of inflammation…

This early-phase study tests whether a special PET scan using a radioactive tracer called 18F-AraG can find tumors in people with esophageal cancer and predict how well they respond to chemoradiation. About 60 adults with untreated, locally advanced esophageal cancer will receive…

This study is testing a new point-of-care diagnostic test for HPV, called the Rice HPV test, to see if it works as well as standard tests. Researchers at MD Anderson Cancer Center will enroll 600 people with a cervix aged 21 or older. The goal is to develop a test that requires l…

This study is testing whether combining the standard CA125 blood test with other tumor markers can help detect ovarian cancer earlier in women who are at low risk. Researchers will track 8,000 postmenopausal women over time, repeating blood tests and sometimes ultrasound if marke…

This study tests whether advanced scans (PET/MR, PET/CT, and whole-body MR) can find leukemia that has spread outside the bone marrow in people newly diagnosed with acute myeloid leukemia (AML). About 77 participants will receive these scans to see how well they detect hidden dis…

This study is testing whether a special type of MRI (called DCE-MRI) can predict jaw bone damage (osteoradionecrosis) in head and neck cancer patients who have had radiation therapy. Researchers will scan up to 1,400 participants before, during, and after radiation to see if chan…

This study tests a new imaging device called the Active Biopsy Guidance System to help doctors decide when and where to take tissue samples (biopsies) from mouth lesions. About 90 adults with suspicious mouth spots or a history of oral cancer will participate. The goal is to see …

This phase I trial is testing a new radioactive tracer called [18F]FTT, which is used with PET/CT scans to find tumor cells in people with solid tumors, including breast, ovarian, and other cancers. The study will enroll 300 participants and aims to see how well the tracer highli…

This study compares two types of breast imaging—molecular breast imaging (MBI) and magnetic resonance imaging (MRI)—to see how well each finds or rules out breast cancer in women at high risk. About 300 women will take part. The goal is to find out if MBI works as well as MRI, wh…

This early-phase study is testing whether a special PET scan using a drug called PYLARIFY can better detect cancer that has spread in people with pancreatic cancer, liver cancer, or breast cancer. About 36 adults will receive the scan, and doctors will compare the results to stan…

This study compares synthetic mammography (a 2D image made from 3D data) to standard digital mammography for detecting breast cancer. Researchers will review medical records from 750 women to see if the synthetic method works as well or better, with the added benefit of lower rad…

This study tests whether a handheld device called the MasSpec Pen can tell the difference between cancerous MPNST, benign neurofibromas, and normal tissue during surgery. About 60 people with MPNST or neurofibroma will take part. The goal is to see if the device is safe and accur…

This study is testing whether a new flexible MRI coil can accurately detect significant prostate cancer in 258 men with intermediate or high-risk disease. The goal is to see if this less invasive approach can reduce the number of unnecessary biopsies. Participants will receive bo…

This pilot study is testing whether magnetic resonance elastography (MRE), a special type of MRI that measures tissue stiffness, can tell apart radiation necrosis (damage from radiation therapy) from recurrent glioma (tumor regrowth) in patients who have already been treated for …

This study in Mozambique is testing two new technologies to improve cervical cancer screening and diagnosis. Researchers will compare a rapid HPV test and a special imaging device against standard methods in about 678 women. The goal is to find faster, more accurate ways to detec…

This study tests whether a special camera and a fluorescent dye called proflavine can help doctors see abnormal cells in the mouth. Researchers will take images of mouth lesions from 275 adults who are already scheduled for surgery. The goal is to see if this non-invasive method …

This pilot study tests whether a special MRI dye called hyperpolarized 13-C-pyruvate can help doctors tell the difference between harmless and dangerous pancreatic cysts. About 20 adults with pancreatic cysts who are scheduled for surgery will receive the dye and have an MRI scan…

This study tests a new imaging device called tVisio-1 that helps doctors see tumor tissue before taking a biopsy sample. The goal is to make biopsies more accurate and reduce complications. About 150 adults with suspected or confirmed cancer will participate at MD Anderson Cancer…

This early-phase study tests a special imaging agent called hyperpolarized pyruvate to see if it can help doctors better diagnose glioma, a type of brain tumor. About 13 adults with brain tumors will receive the agent before an advanced MRI scan. The goal is to improve how tumors…

This study is testing whether contrast-enhanced mammography (CEM) can find breast cancers better than standard mammography in women with dense breasts. Dense breast tissue can hide tumors on regular mammograms, so better imaging is needed. Researchers will enroll 1,000 women aged…

This study tests a special type of mammogram called CESM, which uses a dye injected into a vein to make breast tissue and blood vessels clearer. The goal is to see if CESM is better than standard mammograms at finding the cause of nipple discharge and detecting breast cancer. Abo…

This study looks at whether removing the fallopian tubes first and delaying ovary removal is as safe as removing both at once to prevent ovarian cancer in women with BRCA or other high-risk gene mutations. About 100 premenopausal women will choose either the new two-step approach…

This study looks at whether doing a lymphovenous bypass procedure at the same time as lymph node removal surgery can prevent lymphedema (chronic leg swelling). Twenty adults having groin lymph node surgery will get the bypass and be followed for 2 years. The main goal is to see i…

This study tests whether the drug canakinumab can prevent lung cancer in 50 people who have suspicious lung nodules that haven't gone away. Participants receive the drug and are monitored for nodule shrinkage and cancer development. The goal is to see if this approach can stop lu…

This study tests whether naproxen or aspirin can increase immune cells in the colon to prevent cancer in people with Lynch syndrome, a genetic condition that raises cancer risk. About 40 participants will take one of these drugs or a placebo for a short time. Researchers will mea…

This trial tests whether a different way of closing the abdominal wall during liver tumor surgery can lower the chance of developing an incisional hernia. 140 patients will be randomly assigned to receive either the new 'short stitch' method or the traditional closure. Researcher…

This study tests whether a procedure called lymphovenous bypass, done before underarm lymph node removal, can prevent lymphedema (arm swelling) in patients with breast cancer or melanoma. About 252 participants will receive the bypass during their cancer surgery. Researchers will…

This study tracks how nerve pain from chemotherapy develops in breast cancer patients. It also tests a brain-stimulating device called a closed-loop brain-computer interface to see if it can prevent that pain. About 45 participants will be observed or receive the experimental sti…

This study tests a community-based approach to make cervical cancer screening easier for women who haven't had a Pap test in over 3.5 years. It involves 920 women in low-resource areas of Texas. The goal is to see if this strategy is safe and works well.

This study aims to create an educational tool that helps women and their doctors make informed choices about using a levonorgestrel-releasing intrauterine system (LNG-IUS) to prevent endometrial cancer. Researchers will survey 270 women, both with and without a history of the dis…

This study tests if repairing the lymphatic system during breast cancer surgery can prevent lymphedema, a painful arm swelling. 50 women with breast cancer will receive this reconstruction. The goal is to see if this approach reduces the risk of developing lymphedema.

This study tests high-dose steroids (methylprednisolone or prednisone) in 35 head and neck cancer survivors who have nerve damage from past radiation. The goal is to find the best dose that improves symptoms like tongue weakness while limiting side effects. Participants must be a…

This early-phase study is testing whether a capsaicin patch (made from chili peppers) can relieve nerve pain in the feet and legs caused by chemotherapy. Twenty adults who finished chemo within the past year and have lasting pain will try the patch. Researchers will track side ef…

This study tests whether psilocybin, the active ingredient in magic mushrooms, combined with talk therapy can safely help cancer survivors with depression or anxiety. Twenty adults who have finished cancer treatment and have no brain involvement will receive a single dose of psil…

This phase 2 trial at MD Anderson Cancer Center is testing whether psilocybin-assisted psychotherapy can safely help ease depression and anxiety in 30 adults with advanced cancer who are on maintenance therapy. Participants receive either psilocybin or a placebo (niacin) along wi…

This study looks at whether using a longer IV catheter, placed with ultrasound guidance, can reduce the chance of failure in cancer patients who need IV access in the emergency department. About 400 adults with difficult veins who are expected to stay in the hospital for more tha…

This study tests whether a drug called methylnaltrexone is safe for people with head and neck cancer when taken for two weeks before their surgery. The drug is already used for constipation, but researchers want to see if it can be given safely in this setting. About 25 adults wi…

This study tests whether listening to live or recorded music before neurosurgery can lower stress, improve mood, and reduce pain. Researchers will measure changes in vital signs, stress hormones, and how patients feel using questionnaires. The goal is to find a simple, drug-free …

This study tests whether alteplase, a drug that dissolves blood clots, can improve drainage of fluid around the lungs and reduce shortness of breath in people with cancer-related pleural effusion that is not draining well. About 30 participants will receive either alteplase or a …

This study tests whether expressive writing—reading and writing about positive experiences—can help cancer survivors manage stress. About 414 survivors will participate from home using a computer or smartphone. The goal is to see if this simple activity can lower stress and impro…

This study tests whether olanzapine, a medication typically used for mental health conditions, can reduce opioid cravings and misuse in adults with cancer who are on long-term opioid pain therapy. About 87 participants will receive either olanzapine or a placebo to see if it help…

This study tests a physical activity program designed for cancer survivors and their caregivers. About 164 adults who have finished cancer treatment (except hormone therapy or maintenance chemo) will take part. The goal is to see if the program improves physical function and redu…

This study tests whether a drug called dexrazoxane can protect the heart from damage caused by chemotherapy in people with certain blood cancers, such as acute myeloid leukemia and high-risk myelodysplastic syndrome. About 100 participants will receive dexrazoxane alongside stand…

This study looks at whether a digital art activity can help cancer patients better express their distress, symptoms, and experiences. Researchers will enroll 60 adult cancer patients who are currently receiving treatment. Participants will use a digital tablet to create art and t…

This study tests a community-based course called BBCSI, led by trained peers, to see if it helps Black breast cancer survivors feel better day-to-day. About 46 women with early-stage breast cancer will take part. The goal is to improve quality of life, not to treat the cancer its…

This study looks at whether a simple exercise program is practical and helpful for people with non-small cell lung cancer who are getting radiation therapy, along with their family caregivers. About 40 pairs (patient and caregiver) will take part. The goal is to see if exercising…

This study looks at whether giving only radiation after lumpectomy is safe and effective for women aged 60 and older with early-stage, low-risk breast cancer. The goal is to see if skipping hormone therapy can improve quality of life while still controlling the cancer. About 300 …

This study tests whether a token-based exercise program called TEAM Me can help children and young adults (ages 6-29) with cancer stay active while undergoing a stem cell transplant. Participants earn stickers for walking and other activities, which they can trade for rewards. Th…

This study tests whether combining psychoeducational sessions (like counseling and self-help strategies) with an open-label placebo can reduce fatigue in people with metastatic cancer. Participants will be assigned to one of three groups: education only, placebo only, or both. Th…

This study tests whether a negative pressure wound therapy (NPWT) device, which uses a vacuum to help wounds heal, works better than standard bandages for the abdominal incision in obese patients having breast reconstruction surgery. About 80 participants will be randomly assigne…

This study tests whether custom 3D-printed oral stents can reduce mouth sores in head and neck cancer patients receiving radiation therapy. The stents are made from a mold of the patient's mouth and cover teeth and gums during treatment. Researchers will compare sore rates and pa…

This study aims to improve breast reconstruction after mastectomy by using custom 3D-printed molds to shape tissue into a natural breast form. Researchers will enroll 160 adults scheduled for flap-based reconstruction. The goal is to make surgery more efficient and reduce complic…

This pilot study tests whether a supervised treadmill walking program can help people with early-stage triple-negative breast cancer who are receiving immunotherapy before surgery. The main goal is to see if patients can stick with the exercise routine. Researchers will also chec…

This study explores whether a couple-based meditation program can improve quality of life for people with stage IV lung cancer and their romantic partners. Researchers will enroll 300 couples to attend meditation sessions and complete questionnaires about their health, mood, and …

This study tests a new way to give radiation to people with cancer that has spread to the spine and is pressing on the spinal cord. The goal is to see if giving a slightly higher dose of radiation to the tumor while protecting the spinal cord is safe. About 60 adults with this co…

This study tests a website called Project Prepare that helps head and neck cancer patients stick with swallowing exercises and coping strategies during radiation therapy. The goal is to reduce long-term swallowing problems and improve quality of life. About 300 patients receiving…

This study tests whether adding cryoablation (a procedure that freezes and kills cancer cells) to standard radiation therapy provides better pain relief for people whose cancer has spread to their bones. About 40 participants with various cancers will be split into two groups: on…

This study tests whether a yoga program designed for both patients and their family caregivers can improve physical function, fatigue, sleep, mood, and quality of life. It includes 400 people with lung or esophageal cancer who are getting radiation therapy, plus their caregivers.…

This study tests whether an accelerated recovery program can safely shorten hospital stays for 36 adults undergoing minimally invasive liver surgery. Participants must have a tumor suitable for a specific type of liver resection, no cirrhosis, and live within 50 miles of the medi…

This study tests whether domperidone, a drug that helps the stomach empty food, can reduce symptoms like pain, bloating, nausea, and vomiting in people with chronic digestive disorders. About 200 patients who have not improved with standard treatments will take domperidone and re…

This pilot study tests a spiritual care program called PEACE, led by chaplains and clinicians, for people with advanced cancer. The goal is to see if it helps patients whose faith influences their medical decisions. Sixty participants will receive two counseling sessions or usual…

This study tests whether a diet rich in prebiotic foods can improve the gut microbiome and enhance the effectiveness of first-line immunotherapy in people with advanced melanoma that cannot be removed by surgery. Researchers will enroll 75 adults starting standard immunotherapy a…

This early-phase study tests whether a noninvasive brain stimulation technique called rTMS can help people with impulse control disorders, specifically excessive eating. Researchers will enroll 30 adults aged 21 to 60 with a BMI over 30 to receive personalized, accelerated rTMS s…

This study tests whether nurse-delivered hypnosis before and during breast cancer surgery can lower the amount of opioid painkillers patients need after surgery. About 225 adults having breast surgery will be randomly assigned to receive hypnosis plus standard anesthesia, standar…

This study is testing whether a virtual, 8-session group therapy program can help cancer patients find meaning and reduce emotional distress. Researchers at MD Anderson Cancer Center will enroll 72 adults with a history of cancer. Participants will attend weekly 90-minute session…

This study tracks 50 people who choose radiofrequency ablation (RFA) for benign thyroid nodules or low-risk papillary thyroid cancer instead of surgery. Researchers will monitor long-term outcomes and quality of life using questionnaires. The goal is to see if RFA is a good alter…

This study looks at whether nerve transfer surgery can improve facial movement and quality of life for cancer patients who have facial paralysis after treatment. About 40 adults who are scheduled for this surgery will take part. Researchers will track side effects and measure cha…

This study tests a personalized program called SPOT-ON for cancer patients suffering from severe shortness of breath. Participants will receive a combination of breathing techniques, relaxation methods, posture adjustments, and oxygen-based therapies, either starting early or aft…

This study tests whether a 12-week tele-exercise program called RISE-YA can help reduce cancer-related fatigue in young adults (ages 18-39) who are brain tumor survivors. Participants receive energy conservation counseling, behavior coaching, and exercise training via video calls…

This study tests a short program designed to improve the emotional wellbeing and quality of life of people caring for a loved one with advanced cancer. Researchers will enroll 150 adult caregivers who live with a patient with stage IV cancer. Participants will learn skills to inc…

This study looks at whether having fewer follow-up scans after surgery for soft tissue sarcoma can lower patients' fear of cancer coming back. About 227 adults who finished treatment will be split into two groups: one gets limited follow-up, the other gets intense follow-up. Rese…

This study looks at two ways to treat malignant pleural effusion, a buildup of fluid in the lungs caused by cancer. One uses a small tube (indwelling pleural catheter) to drain fluid; the other adds the antibiotic doxycycline to help seal the lung. Researchers want to see if addi…

This study tests if the drug ustekinumab can control diarrhea and colon inflammation caused by immune checkpoint inhibitors in cancer patients. Ten adults with solid tumors who have moderate to severe symptoms will receive ustekinumab and be monitored for side effects and symptom…

This study tests two supportive care programs—meditation and discussion sessions—for people with advanced (stage IV) cancer and their family caregivers. Researchers want to see if these programs can reduce depressive symptoms and improve quality of life. About 400 patient-caregiv…

This study tests if a nerve stimulation device, used with or without a steroid injection, can improve knee movement and reduce pain better than a steroid injection alone. About 45 adults with long-term knee pain will be randomly assigned to one of three groups. The goal is to fin…

This early-phase trial is testing whether a minimally invasive procedure using special light-activated nails can help stabilize the pelvis in people whose cancer has spread to the bone around the hip socket. Fifty adults with confirmed cancer and visible pelvic metastases will be…

This study tests a program called Focused Acceptance and Commitment Therapy (FACT) for advanced cancer patients who feel anxious about death. 70 participants will attend four weekly 35-45 minute sessions to learn coping skills. The goal is to see if FACT is safe, acceptable, and …

This early-phase study tests whether a weight-loss drug called tirzepatide can help overweight or obese men with intermediate-risk prostate cancer lose weight before their prostate removal surgery. The study will enroll 30 participants and focus on safety and how well the program…

This study is testing whether a yoga program designed to fit different cultures can help cancer patients who are getting a stem cell transplant. About 60 adults in India, Tanzania, and the United States will take part in up to 12 yoga sessions before and during their hospital sta…

This small study at MD Anderson tests whether peripheral nerve stimulation (PNS) can reduce pain from chemotherapy-induced peripheral neuropathy (CIPN). Ten adults with chronic leg pain from past chemo will receive PNS, where thin wires are placed under the skin near nerves to de…

This phase 2 trial tests whether a modern radiation technique called stereotactic body radiotherapy (SBRT) can safely deliver a strong dose of radiation in just 3 to 5 sessions to relieve symptoms from head and neck cancer. The study involves 108 adults whose cancer cannot be cur…

This study tests a parenting support program for 120 parents with advanced cancer and their spouses. The program aims to reduce parenting worries, improve family communication about cancer, and boost emotional wellbeing. Participants must have a child aged 4-16 living at home and…

This study looks at whether giving cancer survivors free healthy food and online cooking lessons can improve their health and well-being. The program is for survivors who struggle to afford food and are treated at a safety-net hospital. Researchers will check if the program is sa…

This study compares symptoms, especially appetite, in patients who have one of two types of minimally invasive stomach cancer surgery: removing only the upper part of the stomach or the whole stomach. Researchers will track how patients feel using a simple questionnaire. The goal…

This study looks at whether a computer-assisted vacuum procedure to remove blood clots from the lungs is safe and improves quality of life for cancer patients with a moderate-risk pulmonary embolism. About 25 adults with cancer and a confirmed clot in a major lung artery will tak…

This study tests whether a CPAP device can reduce tumor movement in lung cancer patients during stereotactic body radiation therapy (SBRT). About 30 participants will use CPAP or deep inspiration breath hold to see which better stabilizes tumors. The goal is to improve treatment …

This study tests whether a virtual group writing program can improve quality of life for young adults who survived cancer. Thirty survivors aged 18-39, diagnosed 1-5 years ago, will write about their cancer experiences in a group setting. The goal is to see if this simple, access…

This study tests whether a custom-made video, showing symptoms and side effects based on each patient's own brain scan, can lower anxiety for people with brain tumors and their caregivers during radiation treatment. About 117 patients with newly diagnosed glioma and their caregiv…

This study tests a newer, more precise radiation method called SBRT against standard radiation to see which better relieves pain from cancer that has spread to the bones. About 220 adults with solid tumors or multiple myeloma and pain at the treatment site will take part. The goa…

This study tests whether using a special MRI scanner combined with a radiation machine (MR-LINAC) during spinal radiation therapy can improve treatment results and quality of life. About 40 adults with cancer that has spread to the spine will receive stereotactic radiosurgery whi…

This early-stage study tests whether a precise radiation dose to the pituitary gland (hypophysectomy) can safely reduce severe cancer pain that hasn't responded to standard treatments like opioids. About 40 adults with advanced cancer and hard-to-control pain will receive this on…

This study is testing whether a mobile app that guides users through yoga poses is practical and safe for people with lung cancer who are getting radiation therapy, and for their family caregivers. About 60 patient-caregiver pairs will try the app at home. The goal is to see if p…

This study tests the ApricityCare program, which helps people with metastatic cancer and their doctors spot treatment side effects early. The goal is to manage these side effects quickly so patients can stay on their cancer therapy longer. About 425 adults starting systemic cance…

This study tests whether training emergency room doctors in palliative care can improve quality of life for patients with advanced lung or gastrointestinal cancer. About 200 participants will be split into two groups: one gets standard ER care, the other gets care from a doctor t…

This study tests a comprehensive yoga therapy program for women with advanced ovarian cancer who are scheduled for chemotherapy and surgery. The program includes dietary advice, movement, breathing exercises, and mental support. Researchers want to see if it is feasible and if it…

This study tests four treatments—haloperidol, chlorpromazine, valproic acid, and a placebo—given through an IV to help calm agitated delirium in hospitalized cancer patients. The goal is to find which option works best to reduce distress and improve comfort. About 42 adults with …

This study tests whether adding bright light therapy, a stimulant (methylphenidate), or melatonin to cognitive behavior therapy can improve sleep and related symptoms like fatigue, anxiety, and depression in 188 adults with advanced cancer. Participants will receive one of these …

This pilot study tests two surgical methods—targeted muscle reinnervation (TMR) and regenerative peripheral nerve interfaces (RPNI)—alone and together to reduce chronic and phantom limb pain in cancer patients who have had an amputation. About 45 adults will be randomly assigned …

This study gathers information from 125 people with von Hippel-Lindau (vHL) disease, a rare genetic condition that causes tumors. Researchers will track disease status, past surgeries and treatments, and quality of life. The goal is to better understand how vHL progresses over ti…

This study tests whether a short video can help more minority patients with prostate cancer join clinical trials. Researchers at LBJ Hospital will show the video to 60 patients and ask them questions before and after. The goal is to find a simple way to make cancer research more …

This study aims to understand why some people respond better to a brain stimulation treatment (rTMS) for smoking. Researchers will measure brain activity in 100 smokers aged 21-60 to see if emotional triggers affect treatment success. The goal is to personalize future therapies f…

This study aims to improve access to cervical cancer screening by using self-collection for HPV testing in safety net health systems. Researchers will interview patients, providers, and stakeholders to understand attitudes and develop training materials. The trial enrolls 7,100 p…

This study is collecting information on side effects from proton therapy in 5,000 adults with many types of cancer. Researchers will track both short-term and long-term side effects and link them to the details of each patient's treatment plan. The goal is to better predict who m…

This study is testing whether a special PET scan (18F-FSPG) and a blood test for tumor DNA can help doctors better guide treatment for liver cancer. About 60 people with hepatocellular carcinoma will receive standard Y90 radioembolization therapy. The goal is to see if these test…

This early-stage trial is testing whether the drug ulixertinib can cross the blood-brain barrier in people with recurrent brain tumors called gliomas. About 40 adults will take the drug before surgery to see how much reaches the tumor and how safe it is. The goal is to learn if t…

This study is a registry that gathers information from 250 people with lung cancer or cancer that has spread to the lungs. Participants will have their tumors treated with a robotic scope inserted through the mouth to burn the tumor. The goal is to learn how well this procedure w…

This pilot study is testing a new imaging agent called [18F]4FN in PET/CT scans for people with chronic graft-versus-host disease (GVHD) affecting their joints. The goal is to see if the agent is safe and can help doctors see joint problems more clearly. Sixteen adults with chron…

This phase 1 trial at M.D. Anderson Cancer Center is testing whether it is safe to collect stem cells from people with RUNX1 familial platelet disorder, a rare inherited condition that raises the risk of bleeding and leukemia. Four participants will receive drugs to mobilize stem…

This study looks at how cancer treatments can cause nerve pain. Researchers will use simple tests, like checking how you feel heat, cold, and touch, along with small skin samples, to understand why this pain happens. The goal is to find better ways to measure and eventually treat…

This study is testing whether a special MRI scan using an inhaled gas called hyperpolarized xenon-129 can help doctors identify and predict lung damage caused by radiation therapy in lung cancer patients. The gas is breathed in instead of being injected like a typical contrast dy…

This study surveys radiology residents to see how comfortable they feel performing simulated endovascular procedures after training on a Mentice simulator. The goal is to improve hands-on training in a safe environment, which could lead to safer patient care. Only 9 residents are…

This study looks at how the COVID-19 pandemic impacted the emotional, financial, physical, and social well-being of adolescent and young adult (AYA) cancer patients and survivors. Researchers will survey 600 participants to measure COVID-related distress and changes in health beh…

This study is testing if a simple blood test can find tiny bits of tumor DNA left after treatment, which might help doctors know if colorectal cancer will return sooner than current methods. About 1,000 people with colorectal cancer who have finished or are about to start treatme…

This study tests whether a simpler food tracking app, MySnackTracker, works as well as traditional full-intake diet logging. Researchers will compare how satisfied people are and how well they stick with each method. About 90 adults who already take part in certain cancer researc…

This study brings together a panel of prostate cancer specialists to agree on the most important pieces of information that should be included in medical records. The goal is to create a standard way to report key data, making it easier for doctors to manage patients from diagnos…

This pilot study at M.D. Anderson Cancer Center is looking at how diet and the microbiome (the bacteria in your gut) might affect the development of colorectal cancer. Researchers will collect tissue, stool, and blood samples from 30 people undergoing screening colonoscopy. The g…

This study tests whether a special type of MRI, called hyperpolarized MRI, can predict how well thyroid and head/neck cancers respond to radiation or drug therapy before surgery. About 42 participants will get this imaging scan before and after starting treatment. The goal is to …

This study watches 40 adults with colorectal cancer who have no visible tumors but still have cancer DNA in their blood (minimal residual disease). Researchers will see how well biomarker-directed therapy, chosen by their own doctor, works to clear that DNA. The goal is to learn …

This study uses repeated MRI scans after radiation therapy to see if they can predict normal tissue damage, like bone death (osteoradionecrosis), in patients with oral cavity or skull base tumors. Researchers will track changes in imaging over time and link them to radiation dose…

This study aims to find women in Texas who are at risk for hereditary breast, ovarian, and colorectal cancers but have limited access to healthcare. Researchers will use mobile mammography units to offer genetic testing and counseling on the spot. Up to 1,000 women will provide a…

This study examines stored tumor tissue and blood samples from 310 people with parathyroid tumors. Researchers aim to find molecular and genetic markers that can better distinguish between benign and cancerous tumors. The goal is to reduce misdiagnosis, unnecessary surgery, and s…

This study compares two approaches after thyroid lobectomy: going home the same day or staying overnight. Researchers will track patient safety, preferences, and healthcare use. About 224 adults having partial or complete thyroid lobectomy will participate, completing surveys bef…

This study follows 260 cancer patients who are on long-term blood thinners for blood clots (VTE). Researchers will ask participants about their quality of life, how well they stick to their medication, and their healthcare costs over 12 months. The goal is to learn what helps or …

This study is a registry that collects information from 200 people with stage III or IV inflammatory breast cancer (IBC). Participants fill out a quality-of-life questionnaire and provide blood samples for MRD testing. The goal is to gather data on how MRD test results relate to …

This study collects extra tissue and fluid from routine lung procedures that would otherwise be thrown away. Researchers will use these samples to better understand lung complications in cancer patients. Up to 12,000 adults undergoing pulmonary procedures at the Cardiopulmonary C…

This study creates personalized computer models of walking to help doctors plan surgery and rehabilitation for people with pelvic sarcomas. Researchers will use motion capture and X-ray imaging to build these models. The goal is to predict the best surgical approach and custom im…

This study is testing a new computer program that helps doctors see which parts of the brain control important functions like language and movement. The goal is to help surgeons plan brain tumor removal more safely. About 1,720 adults with brain tumors who need surgery will take …

This study is testing an educational tool designed for people with melanoma who also have an autoimmune disease and are considering treatment with immune checkpoint inhibitors. Researchers want to see if the tool is easy to use and helpful for both patients and healthcare provide…

This study tests a special brain-mapping grid placed during surgery to better identify areas that control movement and speech. Researchers will compare this method with standard techniques in 75 adults with brain tumors. The goal is to see if the new grid helps surgeons avoid dam…

This study looks at whether a blood test that finds tiny bits of tumor DNA (called cfDNA) can help doctors see if lymphoma is still present after treatment. About 517 adults with diffuse large B-cell lymphoma will give blood samples before and after therapy. The goal is to see if…

This study follows 100 adults with blood cancers (like lymphoma or leukemia) who receive whole brain radiation. Researchers will test memory, thinking, and quality of life over time using MRI scans and questionnaires. The goal is to understand how radiation affects the brain, not…

This study follows 200 people who have had or will have hemipelvectomy surgery for pelvic tumors. Researchers will track physical function and quality of life through questionnaires and fitness tests. The goal is to learn how different surgical methods affect long-term recovery, …

This study looks at how radiation treatment for esophageal cancer affects the body's ability to respond to the pneumonia vaccine. Researchers will give the vaccine to 80 patients who have low white blood cell counts after chemoradiation. They want to see if the vaccine still work…

This study looks at whether joining a support group can improve emotional well-being and reduce feelings of isolation for people with a rare cervical cancer called NECC. About 40 adults with NECC will take part. Researchers will use surveys to measure changes in how participants …

This study watches children aged 2 to 12 who are getting radiation therapy for cancer. Researchers want to see how their anxiety changes over time. The goal is to learn more about their emotional needs, not to test a new treatment.

This study is testing a new type of MRI that uses xenon gas to see how well the lungs are working in people who have had a bone marrow transplant. Researchers will scan 25 transplant patients with or without lung problems, plus 10 healthy volunteers. The goal is to see if this MR…

This study is for adults with certain advanced solid tumors (non-small cell lung cancer, colorectal cancer, or ovarian cancer). Researchers want to find biological markers that show how the experimental drug SAR444881 works, alone or with cemiplimab. About 40 participants will re…

This study looks at how the COVID-19 pandemic impacted out-of-pocket costs, lost wages, and unemployment for 600 breast cancer patients undergoing surgery. Participants will fill out questionnaires about their financial experiences. The goal is to understand the financial toxicit…

This study looks at how lifestyle factors like diet, exercise, mental health, and social support affect quality of life and outcomes in people with melanoma. Researchers will follow 5,000 participants over time using surveys and medical records. The goal is to gather knowledge th…

This study looks at how radiation therapy changes immune cells inside breast cancer tumors. Researchers want to see if radiation helps immune cells enter the tumor to fight cancer. The study involves 36 adults with invasive breast cancer who will receive radiation and have tumor …

This study compares two types of 3D mammography (digital breast tomosynthesis) to see which one makes breast masses and distortions easier to see. About 100 women getting standard screening mammograms will participate. The goal is to improve detection, not to treat any disease.

This study aims to understand what helps or hinders a positive experience for Asian patients being treated for cancer at MD Anderson. Researchers will survey former patients and healthcare providers to identify key factors. The goal is to use these insights to improve care and su…

This study is testing whether a blood test, called a liquid biopsy, can find cancer cells and predict if endometrial cancer will return. Researchers will collect blood and tissue samples from 1,000 women with endometrial cancer before and after treatment. The goal is to see if th…

This study looks at how tamoxifen, a common breast cancer drug, affects certain immune cells called neutrophils. It focuses on a process where neutrophils release web-like traps that may cause side effects. Researchers will study blood samples from 290 women with ER+ breast cance…

This study looks at the financial stress that patients with bone or soft tissue sarcoma face after surgery. Researchers will ask 100 adults to fill out questionnaires about the costs of their cancer care and how that affects their quality of life. No new treatments are being test…

This study looks at what breast cancer survivors and their family members know about chemicals in personal care products that might affect hormones. Researchers also want to see if there is a link between excess weight and these chemicals. About 30 people from the Acres Home comm…

This study tests whether a new screening tool can help people with advanced lung cancer better understand their illness and treatment goals. About 100 patients will either use the tool or receive usual care. The goal is to see if the tool leads to more informed decisions that mat…

This observational study follows 200 people with early blood conditions (MGUS or smoldering myeloma) that sometimes turn into multiple myeloma. Researchers will track age, blood protein levels, bone marrow cells, genes, and bone health to find patterns that predict progression. N…

This study follows 300 people treated for sinonasal, nasopharyngeal, or skull base tumors to track their symptoms and functional changes over time. Participants will complete symptom questionnaires and undergo standard tests like hearing, eye, and speech exams. The goal is to lea…

This study collects tissue and blood samples from 1,500 people with biliary tree cancers, plus healthy volunteers, to look for genetic changes and risk factors. Researchers hope to build models that predict how the cancer develops and responds to treatment. The goal is to better …

This study aims to understand why people with hereditary colorectal cancer syndromes have different symptoms and outcomes. Researchers will compare patients and their family members to see how genes affect the disease. The goal is to learn more, not to test a new treatment.

This study looks at the best ways to teach heavy smokers about lung cancer screening using tobacco quitlines. Researchers will work with 800 participants, including quitline staff and smokers aged 55-80 with a heavy smoking history. The goal is to see what methods work best to sh…

This study tests a decision-making tool for women newly diagnosed with early-stage breast cancer who are considering removing the healthy breast as a preventive measure. The tool aims to improve knowledge and reduce uncertainty about the choice. Only 15 participants are enrolled,…

This study looks at occupational stress in surgeons and musicians by using wearable brain monitors, saliva tests, and questionnaires. Researchers want to understand how these demanding jobs affect the body and mind. The study involves 20 adults and is run by MD Anderson Cancer Ce…

This study is for 1000 people with oral cancer or precancerous mouth lesions. Researchers will collect tissue samples and ask participants about their symptoms before, during, and after treatment. The goal is to find better ways to predict how the disease will behave and which tr…

This study creates a registry for people with inflammatory breast cancer, a rare and aggressive form of the disease. Researchers will collect blood, tissue, and stool samples along with medical information from up to 1,200 participants. The goal is to build a resource for future …

This study looks at how walking and sleep habits affect recovery in people having lung cancer surgery. About 240 patients will wear a Fitbit to track their steps and sleep, and some will get extra support to increase walking. The goal is to see if more walking leads to fewer comp…

This study is developing and testing an educational tool to help men aged 65 and older with prostate cancer decide with their doctors whether to reduce the frequency of follow-up tests like biopsies. The tool is being tested with 45 participants, including patients, caregivers, a…

This study is collecting information from 100 adults with blood cancers who receive CAR-T therapy, radiation therapy, or both within a 90-day window. Researchers will review medical records to track outcomes like disease progression, side effects, and survival. The goal is to lea…

This study reviews medical charts of up to 3,000 chronic myelogenous leukemia (CML) patients who received standard tyrosine kinase inhibitors like imatinib outside of a clinical trial. Researchers want to understand real-world treatment patterns, responses, side effects, and preg…

This study asks 500 people with Li-Fraumeni syndrome (or their parents) to fill out a questionnaire about why they would or would not join a future trial comparing standard genetic counseling to a personalized version. The goal is to understand what factors influence their decisi…

This study is testing a new questionnaire called SOCS-OTS to see if it can correctly identify cancer survivors who need occupational therapy. Researchers at MD Anderson will compare it to a standard screening tool in 80 adults. The goal is to make sure the new tool accurately fin…

This study looks at the quality of life of people with two early blood conditions: MGUS and smoldering myeloma. Researchers will ask 400 participants to fill out short questionnaires about their symptoms and concerns. The goal is to learn what matters most to patients, not to tes…

This study uses a 10-minute questionnaire to learn how the COVID-19 pandemic impacted the quality of life, mental health, finances, and social connections of people with melanoma. Researchers will also look at what factors, like social support, helped people cope. About 1,152 par…

This study tests whether a non-invasive handheld device that measures pupil size and reactivity can predict neurological side effects in patients receiving CAR-T cell therapy for lymphoma. Researchers will monitor 100 adults before and after treatment to see if pupil changes sign…

This study aims to create a shared decision-making tool for Spanish-speaking women with advanced ovarian cancer. The tool will help them and their doctors discuss and choose maintenance therapy after chemotherapy. About 70 patients will test the tool to see if it reduces regret a…

This study looks at a method called 'Teaching the Teachers' to help spread liver cancer diagnosis guidelines. Experts learn the guidelines first, then teach other radiologists around the world. The goal is to see if this approach increases how often the guidelines are used. About…

This study looks at why people with head and neck cancer follow (or don't follow) swallowing exercises after radiation. Researchers will use blood tests and questionnaires to see if immune system proteins or feelings about the disease affect exercise habits. The goal is to find w…

This study at MD Anderson Cancer Center tests whether advanced MRI (AMRI) can help doctors better target brain tumor biopsies. About 62 adults with brain lesions will get an AMRI scan before standard surgery. Researchers compare biopsy results from AMRI-guided spots to those from…

This study enrolls 75 lung cancer patients under age 50 to see if a dedicated care program improves their satisfaction and well-being. Participants fill out surveys over five years about their needs, quality of life, and experience with peer support. The goal is to understand wha…

This study is creating a large database of how patients recover after bladder cancer surgery (radical cystectomy). Researchers at MD Anderson and other centers will collect information from patients and doctors about symptoms and recovery. The goal is to understand what helps peo…

This study aims to understand how rheumatic side effects (like arthritis) from cancer immunotherapy affect patients' daily lives. Researchers will interview 20 adults who have experienced these side effects to learn about their severity and impact. The goal is to improve future c…

This study follows 430 people with stage I-IV rectal cancer to measure their quality of life after surgery. Participants fill out questionnaires about their well-being and daily function. The goal is to learn how surgery impacts patients over time, not to test a new treatment.

This study will adapt educational materials about medullary thyroid cancer to be more culturally appropriate and easier to understand for Spanish-speaking Hispanic or Latino patients. Researchers will interview 40 participants, including patients and caregivers, to gather feedbac…

This study looks at how much of the radioactive drug Pluvicto reaches tumors and organs in patients whose kidneys or bone marrow are not working well. About 25 people will be enrolled to check for side effects and safety. The goal is to better understand dosing in these patients,…

This study is testing whether giving nutrition through a feeding tube after a stem cell transplant is safe and practical. It involves 40 children and young adults aged 2 to 25. The goal is to see if this method works better than standard care.

This study aims to understand how social and financial challenges influence the results of transplant and cell therapy treatments. Researchers will follow 2,000 adult patients at MD Anderson Cancer Center and ask them about their social circumstances. The goal is to identify barr…

This study looks at how the bacteria in your gut might cause stomach issues like diarrhea and colitis when you take certain cancer drugs called immune checkpoint inhibitors. Researchers will collect stool, blood, and tissue samples from 800 people with melanoma, lung cancer, or g…

This study looks at abnormal cells in the lungs of 15 people who developed bronchiolitis obliterans syndrome after a stem cell or lung transplant. Researchers want to understand these cells better so doctors can spot the disease earlier in future patients. Participants will have …

This study observes adults with advanced thyroid cancer who are receiving standard treatments in real-world settings, not in clinical trials. Researchers aim to understand barriers to accessing care and how well patients tolerate and respond to available medications. About 459 pa…

This study looks at how chemoradiation for locally advanced lung cancer affects the heart. Researchers will track 100 patients using heart tests, blood samples, and questionnaires. The goal is to see if tailoring treatment based on individual risk can reduce heart problems.

This study looks at how sleep and physical activity change for blood cancer patients and their caregivers after a stem cell transplant. Researchers will use a Fitbit to monitor activity, sleep, and heart rate, and ask participants to complete questionnaires about their quality of…

This study looks at how healthcare providers and caregivers perceive discomfort in advanced cancer patients who have hypoactive delirium, a state where patients are unresponsive and withdrawn. Researchers will ask both groups to fill out questionnaires about the patient's discomf…

This study uses a large registry of 2030 people with medullary thyroid cancer to track how the disease develops and spreads. Researchers will collect medical records, genetic data, and patient surveys to better understand the cancer's natural history. The goal is to improve how a…

This study looks at how the way medical information is presented influences treatment choices for people with advanced cancer. About 400 participants will fill out questionnaires and review made-up case scenarios. The goal is to learn how to better communicate health options to e…

This study asks brain cancer patients about their experience with telemedicine compared to in-person visits. Researchers want to learn if patients feel they receive good care through virtual appointments. The goal is to improve how care is delivered to people with brain tumors.

This study gathers blood, saliva, urine, and stool from up to 1,600 children with recurrent or chronic pancreatitis. Researchers look for genetic markers that might increase the risk of pancreatic cancer later in life. No treatment is given—the goal is simply to learn more about …

This study is creating a registry of 750 people with a rare and aggressive form of cervical cancer called neuroendocrine carcinoma. Researchers will collect information from medical records to learn more about the disease, how it is treated, and what happens to patients over time…

This study is testing whether having additional MRI scans during radiation and chemotherapy can help doctors see how a high-grade glioma (a type of brain tumor) is changing. The goal is to use that information to adjust the treatment plan for each patient. About 80 adults with th…

This study aims to create and test an educational tool that teaches people how to prevent liver cancer. About 40 adults who have not been diagnosed with liver cancer will review the materials and share their thoughts. The goal is to make sure the information is clear, helpful, an…

This study explores whether magnetic resonance spectroscopy (MRS) can be used to safely evaluate spinal cord lesions. Researchers will test the technique in healthy volunteers and patients with leptomeningeal disease who are receiving radiation. The main goal is to see if MRS is …

This study reviews medical records from 600 lung cancer patients who had surgery between 2004 and 2019. The goal is to see if the use of robotic surgery has led to more atypical segmentectomies (removing part of a lung lobe). Researchers want to understand how robotic methods com…

This study tests whether a telementoring program called ECHO can improve the quality of palliative care for advanced cancer patients in underserved areas of Kenya, Nigeria, Ghana, South Africa, India, and Ethiopia. Researchers will train local doctors through online clinics and w…

This study will test whether special MRI scans can accurately detect and track damage to the mouth and jaw caused by radiation therapy for head and neck cancers. Researchers will enroll 300 adults undergoing radiation, with some receiving additional MRI scans before and after tre…

This study tests tumor tissue from up to 12,000 cancer patients to find gene changes (mutations). The goal is to match each patient with a clinical trial or therapy that targets their specific cancer type. Researchers will also build a database of mutations to help future patient…

This study interviews cancer care providers, patients, and caregivers to learn their thoughts and feelings about receiving hospital-level care at home. The goal is to understand what people know and believe about home hospital care, so that future programs can be designed to bett…

This study is collecting medical records and lab results from 70 people diagnosed with a rare type of cervical cancer called clear cell carcinoma. Researchers want to understand the cancer's features and molecular profile better. No new treatments or drugs are being tested—this i…

This early trial tests a rice-sized microdevice implanted into sarcoma tumors. The device releases tiny doses of up to 10 different drugs to see which ones kill cancer cells. The goal is to check if the device is safe and can help choose the best treatment for each patient. The s…

This study is looking for people who have finished a weight loss program to share their thoughts on a mobile app that tracks food and drinks. Participants will join focus groups or interviews to discuss what they like and dislike about the app. The goal is to help doctors and app…

This study tracks 170 advanced cancer patients receiving anti-VEGF therapies to record side effects and see how the disease responds. Researchers hope to find patterns linking complications to treatment success. The goal is to help doctors better understand and manage these thera…

This study tracks 150 people with non-small cell lung cancer who are getting chemotherapy and radiation followed by immunotherapy. Researchers collect blood, saliva, stool, and lung fluid samples, along with regular lung function tests, to find early signs of lung inflammation (p…

This study is creating a large collection of mammogram images, blood samples, and health information from 10,000 women getting routine screening mammograms. The goal is to build a resource for future research on breast cancer and women's health. Participants provide a blood sampl…

This study aims to help Black individuals and their families in Houston learn about their risk for hereditary cancers like breast and colorectal cancer. Researchers will use a simple questionnaire and remote genetic counseling to connect people with testing. The goal is to make g…

This study is creating a decision aid called TA-DA to help people with advanced cancer talk with their doctors about whether to try more treatments after several have already failed. The tool is designed to support shared decision-making. Researchers will test it with 155 patient…

This study follows 100 men with low- or very low-risk prostate cancer who choose active surveillance instead of immediate treatment. Researchers will use questionnaires, exams, biopsies, and MRIs every 6 months to 2-3 years to monitor disease progression over 5 years. The goal is…

This study builds a database of 1000 breast cancer survivors aged 50 or younger who have dense breast tissue. Researchers will track their MRI scans over time to see if MRI helps find new cancers that mammograms might miss. No new treatments are tested; the goal is to gather info…

This study gathers medical records and leftover tissue samples from up to 2,000 people with low-grade ovarian or peritoneal tumors. The goal is to create a detailed database that helps researchers learn more about these rare cancers and how they are treated. No new drugs or proce…

This study surveys pulmonologists across the US to understand how the COVID-19 pandemic changed their lung procedure practices, staffing, and operations. Researchers hope the findings will help guide future pandemic responses and improve care. About 250 doctors who are members of…

This study looks at how to get cancer clinics to use a standard tool called DIGEST to measure swallowing problems. Researchers will compare different training methods to see which works best. The goal is to improve how swallowing issues are tracked and managed in cancer care.

This study is for adults about to start immune checkpoint inhibitor therapy for cancer. Researchers want to understand why some patients develop heart problems from this treatment. They will analyze blood samples and genetic factors from 1200 participants to find clues that could…

This study is testing a decision aid to help people decide whether to get screened for lung cancer. The tool is designed for patients in a safety-net healthcare system. Researchers will enroll 360 current or former smokers aged 50-80 to see if the aid is safe and helpful.

This study surveys up to 20,000 employees of MD Anderson Cancer Center to understand how the COVID-19 pandemic affected their mental health and stress levels. Participants fill out questionnaires about stress and trauma-related symptoms. The goal is to identify which workers are …

This study follows 100 people diagnosed before age 20 with mycosis fungoides or lymphomatoid papulosis, rare skin conditions. Researchers will check their health and ask about long-term effects. The goal is to understand how these diseases progress over time, not to test a new tr…

This study is testing whether checking troponin levels in the blood before each dose of immune checkpoint therapy can help catch heart problems early. 980 cancer patients will either get regular troponin monitoring or standard care. The goal is to see if this approach lowers hear…

This study aims to help heavy smokers aged 55 to 80 make informed decisions about lung cancer screening. Researchers are updating a decision aid and testing it with 620 participants. The goal is to improve understanding and support better choices, not to treat or prevent disease.

This study is developing a new system to measure how cancer and its treatment affect patients' symptoms and quality of life. Researchers will ask 6,500 participants—including patients, caregivers, and healthcare providers—to complete interviews and questionnaires. The goal is to …

This study looks at how a person's ancestry and financial situation influence their choice of bone marrow donor cells and whether they receive a genetically matched transplant. Researchers will follow 1,200 adults who are candidates for allogeneic transplantation. The goal is to …

This study is testing a special type of MRI scan to see if it can better measure how colorectal cancer liver tumors respond to chemotherapy. About 70 people with liver metastases that have not been treated yet will get the scan before and after chemo. The goal is to improve how d…

This study aims to learn how patients rate their symptoms during or after radiation therapy using different questionnaires. Researchers want to see if different rating scales give similar or different results. The study involves 300 adults with head and neck cancer who are curren…

This study looks at whether CT scans can help doctors predict how well chemotherapy will work for people with pancreatic or liver cancer. About 259 adults with these cancers will get CT scans before and during treatment. The goal is to see if changes in the scan can tell if the t…

This study talks to women with and without endometrial cancer to learn what they know about risk factors and prevention options. Researchers hope to create a tool that helps women make informed decisions. About 45 women will take part at MD Anderson Cancer Center.

This pilot study looks at how often women experience posttraumatic stress disorder (PTSD) after gynecologic brachytherapy, a type of internal radiation. Researchers want to find better ways to keep patients comfortable and reduce psychological distress when the treatment applicat…

This study looks at whether measuring a patient's energy reserve (fitness) before major cancer surgery can help predict how well they recover. Researchers will use a special exercise test to measure gas exchange and see if it relates to complications after surgery. The goal is to…

This study creates and tests a decision aid for people with medullary thyroid cancer and their caregivers. The tool helps them discuss with their doctors whether to start or stop drugs, join clinical trials, or continue active monitoring. About 120 participants, including patient…

This study is testing whether wearing a fitness tracker (like a Fitbit) can give doctors a better picture of how active cancer patients are, and whether that activity level relates to how well they are doing overall. About 590 people with various cancers will wear activity monito…

This study follows people who have already received gene transfer therapy for cancer or other conditions. The goal is to monitor long-term safety and any side effects over up to 15 years. No new treatment is given; participants provide health updates and occasional blood samples.…

This study is creating a database of medical information from 2,000 people with mesonephric-like adenocarcinoma (MLA), a very rare type of uterine cancer. Researchers hope to learn more about how MLA behaves and what makes it different from other cancers. No treatments or tests a…

This study looks at how people with both cancer and heart failure feel day-to-day. Researchers will ask 100 participants about their symptoms and quality of life using simple questionnaires. No new treatments are tested—the goal is to better understand the challenges these patien…

This study is testing whether a specially designed video game can help young people (ages 15-39) who have had a stem cell transplant for leukemia or lymphoma improve their health habits. Researchers will gather feedback from 40 participants to see if the game is easy and enjoyabl…

This study is following over 2,300 people across the US to better understand chronic pancreatitis, a painful long-term condition of the pancreas. Researchers will track participants' symptoms and disease changes over time to identify what causes the disease and how it progresses.…