Can old drugs stop Radiation's lingering damage? new trial aims to find out
NCT ID NCT06912763
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests several medications—including pravastatin, pentoxifylline, and others—to see if they can treat or prevent lymphedema and fibrosis caused by radiation therapy in head and neck cancer survivors. About 250 participants who have finished radiation at least 6 months ago and have swelling or tissue hardening will be randomly assigned to one of the drugs or standard care. The goal is to find the safest and most effective option to ease these long-term side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Pravastatin, Pentoxifylline, Ketoprofen, Pirfenidone, Tocopherol
What this could lead to
If successful, this could identify an effective drug combination to reverse or prevent painful swelling and tissue hardening after radiation, improving quality of life for head and neck cancer survivors.
What could go wrong
This is a mid-stage trial with multiple drugs, so it is unclear which, if any, will work. Side effects like muscle pain or liver issues are possible, and results may not apply to all patients.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact