LYMPHEDEMA

This phase 2 trial tests several medications—including pravastatin, pentoxifylline, and others—to see if they can treat or prevent lymphedema and fibrosis caused by radiation therapy in head and neck cancer survivors. About 250 participants who have finished radiation at least 6 …

This study compares two ways of treating chronic leg swelling (lymphedema) using compression bandages. One group receives the standard treatment with a single bandage application each day, while the other group applies the bandage three times daily. The goal is to see if the more…

This study will test the Symani Surgical System, a robotic device designed to help surgeons perform delicate microsurgery on lymph vessels in the head and neck. The goal is to see if the robot can safely and effectively reconnect lymph channels to reduce swelling (lymphedema) in …

This study is testing the Symani Surgical System, a robotic device designed to help surgeons perform very delicate microsurgeries. The trial will include 455 adults undergoing free tissue transfer or lymphedema surgery. Researchers will check how well the robot works for reconnec…

This study is testing a robotic system called Symani to help surgeons perform delicate microsurgery for two types of procedures: free tissue transfer (moving tissue from one part of the body to another) and lymphatic surgery (to treat lymphedema, a condition causing swelling). Ab…

This phase 2 trial tests whether pravastatin (a cholesterol drug) or a combination of pentoxifylline and vitamin E can prevent lymphedema and fibrosis (swelling and scarring) caused by radiation therapy in head and neck cancer patients. About 295 adults with oropharyngeal cancer …

This study tests whether a ketogenic diet or ketone supplements can improve lymphatic function in people with lymphedema, a condition causing arm swelling after lymph node removal. 81 participants will be randomly assigned to a ketogenic diet, an isocaloric diet, or ketone supple…

This study uses special ultrasound techniques to find clear differences between lymphedema and lipedema, two chronic conditions that cause leg swelling and are often hard to tell apart. Researchers will compare 75 adults—those with lymphedema, those with lipedema, and healthy vol…

This study tests a low-risk surgical procedure called LYMPHA, done at the same time as breast cancer lymph node removal, to prevent lymphedema—a chronic, painful arm swelling. About 80 women undergoing breast cancer surgery will be randomly assigned to receive LYMPHA or standard …

This study tests if repairing the lymphatic system during breast cancer surgery can prevent lymphedema, a painful arm swelling. 50 women with breast cancer will receive this reconstruction. The goal is to see if this approach reduces the risk of developing lymphedema.

This study tests whether a comprehensive program can prevent lymphedema (chronic arm swelling) in women undergoing lymph node removal for breast cancer. The program includes immediate lymphatic reconstruction during surgery, self-directed lymphatic massage, and regular arm measur…

This study looks at whether doing resistance exercises (like leg presses) can reduce swelling in the lower legs of people with lymphedema. It also checks if wearing compression garments during exercise makes a difference. Thirty-six adults with lower limb lymphedema will exercise…

This study is testing a new portable device called Dayspring that uses active compression to reduce leg swelling from lymphedema or phlebolymphedema. It will involve 100 veterans and measure cost savings, mobility, and symptom severity. The device is non-pneumatic, meaning it doe…

This study tests whether two non-invasive therapies—extracorporeal shock wave therapy and pulse electromagnetic field therapy—can reduce swelling and improve quality of life in people with lymphedema after cancer treatment. Ninety participants will receive one of the therapies or…

This study tests whether adding virtual reality (VR) exercises to standard therapy can improve walking, reduce leg swelling, and boost quality of life in people with lower limb lymphedema. Forty adults with stage 2 or 3 lymphedema after cancer surgery will either receive standard…

This study follows breast cancer patients who are receiving targeted therapy to see if they develop arm swelling, known as lymphedema. Researchers use two devices—a Perometer and a SOZO device—to measure changes in arm volume and fluid levels. The goal is to detect lymphedema ear…

This study follows 1,250 women who have had lymph node removal during breast cancer surgery. Researchers use arm measurements and tissue tests to see who develops lymphedema (arm swelling) and why. The goal is to find early warning signs and improve quality of life.

This study follows 100 women with early-stage breast cancer for two years after surgery and treatment. Researchers will measure changes in muscle mass, body fat, and strength using simple tests. The goal is to understand how the body recovers and what factors affect quality of li…

This study aims to understand why lymphedema develops by comparing gene activity in swollen versus healthy limbs. Researchers will take tiny tissue samples from 60 adults with primary or secondary lymphedema. The goal is to identify molecular differences that could point toward f…

This study follows 10,000 breast cancer patients to detect lymphedema—arm swelling that can occur after treatment—as early as possible. Researchers use arm measurements and patient surveys to track changes in symptoms, function, and quality of life. The goal is to improve outcome…

This study is creating a collection of blood, urine, and stool samples from 500 adults with or at risk for heart and blood vessel diseases. Researchers will use these samples to study inflammation, blood clotting, and other biological pathways. The goal is to build a resource tha…

This study checks if people with lymphedema have higher levels of lipoprotein(a), a substance linked to heart disease. Researchers will test blood from 100 adults with lymphedema to see how common high LP(a) is. The goal is to learn if lymphedema patients need extra heart risk mo…

This study follows 600 people with lymphedema to compare quality of life between those who choose surgery (a lymph node transfer) and those who choose non-surgical management. Participants fill out questionnaires about their symptoms and daily life over time. The goal is to under…