LYMPHEDEMA

This study tests whether two existing drugs—pentoxifylline with vitamin E, or pravastatin—can prevent or reduce lymphedema and fibrosis (tissue hardening) caused by radiation therapy for head and neck cancer. About 295 adults will receive one of these treatments alongside standar…

This study tests whether a ketogenic diet or ketone supplements can improve lymph vessel function and reduce swelling in people with arm lymphedema after lymph node removal. Researchers will compare a ketogenic diet to a standard diet, with or without a ketone supplement, in 81 p…

This study is testing a surgical robot called Symani to help surgeons perform very delicate microsurgery, such as reconnecting tiny blood vessels during tissue transfer or treating lymphedema (chronic swelling). About 455 adults will take part, and researchers will check if the r…

This study is testing a robot-assisted surgical system called Symani for very delicate microsurgery, such as reconnecting tiny blood vessels or treating lymphedema (swelling). About 180 adults who need these surgeries will take part. The goal is to see if the robot helps make the…

This study tests if adding medication can treat or prevent lymphedema and fibrosis (tissue hardening and swelling) caused by radiation therapy in head and neck cancer survivors. Researchers will compare different drugs to find the most effective one. The trial involves 250 partic…

This study aims to improve how doctors tell apart lymphedema and lipedema, two chronic conditions that cause leg swelling and are often confused. Researchers will use special ultrasound techniques to measure skin thickness and tissue stiffness in 75 people (25 with lymphedema, 25…

This study tests whether repairing the lymphatic system during breast cancer surgery can prevent lymphedema, a painful arm swelling. Researchers will enroll 50 women with breast cancer who are already scheduled for lymph node removal. The goal is to see if this extra surgical ste…

This study tests whether a comprehensive prevention program can reduce the risk of lymphedema (arm swelling) in women with breast cancer who have lymph nodes removed. About 285 participants will be followed for at least a year. The program focuses on helping lymph fluid drain pro…

This study tests a low-risk surgical procedure called LYMPHA, done at the same time as breast cancer lymph node removal, to prevent lymphedema—a chronic, painful arm swelling. About 80 adults undergoing breast cancer surgery will be randomly assigned to receive LYMPHA or standard…

This study tests whether virtual reality (VR)-assisted exercises, added to standard therapy, can improve walking, physical function, and quality of life in people with lower leg lymphedema (chronic swelling). About 40 adults aged 18-65 with stage 2 or 3 lymphedema after cancer su…

This study tests two non-invasive therapies—extracorporeal shock wave therapy and pulse electromagnetic field therapy—for people with lymphedema after breast or gynecologic cancer. Lymphedema causes painful limb swelling that makes daily tasks hard. The goal is to see if these tr…

This study looks at whether progressive resistance exercise (like lifting weights) can improve symptoms and arm function in people who develop lymphedema after breast cancer treatment. About 50 adults aged 18-60 who are at least 3 months past surgery will be randomly assigned to …

This study looks at whether adding aerobic exercise to standard treatment helps people with chronic leg swelling walk better, keep their balance, and strengthen their legs. Twenty-four adults aged 20 to 60 with swelling in both legs will either get standard therapy alone or stand…

This study looks at whether resistance exercise (like leg presses) can reduce swelling in the lower leg for people with lymphedema. Participants will exercise with and without compression garments to see which works better. The goal is to find safe, effective ways to manage lymph…

This study tests a new, portable leg compression device for people with lymphedema or phlebolymphedema (leg swelling due to vein problems). About 100 adults will use the device at home to see if it improves mobility, reduces swelling, and lowers healthcare costs compared to stand…

This study looks at the genes active in the swollen limbs of people with lymphedema, both inherited and after cancer treatment. By comparing gene activity in healthy and affected tissue, researchers hope to understand what causes the fluid buildup. The goal is to find new targets…

This study looks at whether people with lymphedema (chronic swelling) have higher levels of a blood fat called lipoprotein(a), which is linked to heart attacks and strokes. Researchers will test 100 adults with lymphedema to confirm early findings that this marker is more common …

This study follows 1,250 women who have had lymph nodes removed during breast cancer surgery to see how many develop lymphedema (arm swelling). Researchers will also look at breast tissue removed during surgery for signs of inflammation that might raise risk. Participants will an…

This study follows 10,000 breast cancer patients to detect lymphedema—arm swelling—as early as possible. Researchers use arm measurements, symptom surveys, and quality-of-life questionnaires to spot changes during and after treatment. The goal is to improve outcomes by catching l…

This study collects blood, urine, and stool samples from 500 adults with or at risk for heart and blood vessel diseases. The samples are stored in a biobank for future research on inflammation, metabolism, and other disease pathways. No treatments or interventions are given; the …

This study looks at how lymphedema patients' quality of life changes over time, comparing those who choose surgery (a lymph node transfer) with those who choose non-surgical care. Researchers will follow 600 adults aged 18 to 80 with arm or leg swelling. The goal is to understand…

This study follows 100 women who had breast cancer surgery and therapy to see how their muscle mass and body fat change over two years. Researchers will measure muscle strength and body composition regularly. The goal is to understand the long-term physical effects of cancer reco…