LYMPHEDEMA

This study is testing whether changing the body's metabolism through a ketogenic diet or ketone supplements can improve the function of the lymphatic system and reduce swelling in people with arm lymphedema. Researchers will compare a strict ketogenic diet, a standard diet with k…

This study is testing two non-invasive therapies to see if they can help control lymphedema, a condition that causes painful and disfiguring limb swelling, often after cancer treatment. Researchers will apply shock wave therapy (like that used for tennis elbow) and pulsed electro…

This study is evaluating a robotic surgical system called Symani for performing extremely delicate microsurgery procedures. The research will follow 455 patients undergoing reconstructive surgery (like breast reconstruction after cancer) or lymphedema surgery to see if the roboti…

This study is testing whether advanced, non-invasive ultrasound techniques can help doctors accurately tell the difference between two conditions that cause leg swelling: lymphedema and lipedema. Researchers will compare ultrasound scans from 75 people—some with lymphedema, some …

This study is testing whether a comprehensive prevention program can help drain fluid from the arm and stop lymphedema (chronic arm swelling) from developing. It involves 285 women with breast cancer who are having surgery to remove lymph nodes under their arm. The main goal is t…

This study is testing if a surgical procedure called LYMPHA, done during lymph node removal for breast cancer, can prevent lymphedema—a chronic, painful swelling of the arm. Researchers will compare outcomes in 80 patients to see if the procedure reduces swelling risk and improve…

This study is testing if two common medications—pentoxifylline with vitamin E or pravastatin—can prevent or reduce painful swelling and scarring (lymphedema and fibrosis) that often occurs after radiation treatment for head and neck cancer. The trial will enroll about 295 adults …

This study is testing whether rebuilding the body's lymph drainage system right after lymph node removal for breast cancer can prevent a painful, chronic swelling condition called lymphedema. It will follow 50 women for two years to see if this immediate surgical repair keeps the…

This study is testing whether a simple arm-strengthening exercise program done at home can help manage lymphedema, a common and often painful swelling that can occur after breast cancer treatment. Researchers will compare two groups of 50 female participants: one doing the exerci…

This study is testing a new portable compression device designed to reduce leg swelling caused by lymphedema or poor circulation. It will involve 100 adults with these conditions to see if the device improves their quality of life, mobility, and leg measurements. The research wil…

This study aims to find out if certain medications can help treat or prevent lymphedema (swelling) and fibrosis (scarring) caused by radiation therapy in head and neck cancer survivors. Researchers will test different drugs in 250 participants to see which one is most effective a…

This study is testing if adding aerobic exercise to standard leg swelling therapy helps people with lymphedema walk better, improve their balance, and get stronger. It will involve 24 adults with swelling in both legs. Half will do standard therapy plus aerobic exercise, while th…

This study aims to compare the long-term quality of life for people with lymphedema who choose to have a specific surgery (vascularized lymph node transfer) versus those who choose non-surgical management. It will follow 600 adults with arm or leg swelling to see which approach h…

This study aims to understand if people with lymphedema (a condition causing chronic swelling) are more likely to have high levels of a specific blood marker called Lp(a), which is linked to heart disease. Researchers will test 100 adults with lymphedema to see how common this is…

This study aims to create a long-term collection of biological samples to help researchers better understand heart and blood vessel diseases. It will collect blood, urine, and stool samples from 500 adults who have or are at risk for these conditions. The goal is to build a share…

This study aims to understand how breast cancer treatment affects body composition over time. Researchers will follow 100 patients for 2 years after surgery and therapy to track muscle loss, fat changes, and physical function. The goal is to gather detailed information about the …

This study aims to better understand and detect arm swelling (lymphedema) in people who have been treated for breast cancer. Researchers will follow 10,000 patients, regularly measuring their arms and asking about symptoms and quality of life. The goal is to learn how to spot thi…

This study aims to understand the biological differences between inherited lymphedema and lymphedema that develops after cancer surgery. Researchers will compare tissue samples from 60 adults with either type of lymphedema to their own healthy tissue. The goal is to identify spec…