Could reapplying compression bandages three times a day beat the standard Once-Daily treatment for lymphedema?

NCT ID NCT07708662

Disease control Sponsor: Universiteit Antwerpen Source: ClinicalTrials.gov ↗

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study compares two ways of treating chronic leg swelling (lymphedema) using compression bandages. One group receives the standard treatment with a single bandage application each day, while the other group applies the bandage three times daily. The goal is to see if the more frequent approach reduces swelling faster and helps maintain results over a year. The trial involves 160 adults with lower-limb chronic edema who can follow instructions in Dutch.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: boosted compression therapy (three daily applications of a multicomponent short stretch compression bandage)
What this could lead to: If it works, this approach could shorten the time needed to reduce swelling and improve long-term management of chronic leg edema.
What could go wrong: This is a relatively small trial (160 participants) and the added burden of reapplying bandages three times daily may reduce patient adherence or not prove more effective than standard care.

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Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 160 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: * Patients suffering from chronic edema ( \> 3 months) of the lower extremity with a positive pitting sign and a conservative treatment is prescribed. -≥ 18 years old * BMI is \<36 * Able to understand and follow instructions in Dutch Exclusion criteria: * All treatable causes of chronic edema, such as hormonal disturbances (e.g. thyroid dysfunction), protein abnormalities (especially Albumin), cardiac insufficiency, nephrological conditions, drug-induced edema or peripheral arterial disease. * Peripheral arterial disease (ABI \< 0.55) * The patient is allergic for one of the products we use during the treatment, and no alternative is available * The patient has wounds at the level of the treated edema zone. * The patient is currently receiving treatment within the convention "lymfoedeem" according to the Belgian Health insurance (RIZIV-INAMI). * The patient is not able to give written consent.

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Conditions

The condition(s) this trial relates to.

lymphedema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic edema Lymphedema

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

4 sites. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Could reapplying compression bandages three times a day beat the standard Once-Daily treatment for lymphedema?

What the study statuses mean