Sound waves could reveal hidden fluid in swollen limbs

NCT ID NCT04258319

ENROLLING_BY_INVITATION Diagnosis Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This study tests a new ultrasound technique called SAVE that measures how stiff and fluid-filled arm tissues are in people with lymphedema. Researchers want to see if this method can accurately tell the difference between a swollen arm and a healthy one. If it works, it could help doctors better monitor the condition and stage its severity without invasive tests.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this ultrasound technique could give doctors a simple, non-invasive way to track lymphedema severity and guide treatment decisions.
What could go wrong: This is an early validation study with only 90 participants. The method may not prove accurate enough for routine clinical use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

lymphedema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LYMPHEDEMA

Contacts and locations

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Locations

Mayo Clinic

Jacksonville, Florida, 32224, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States

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