Lymphedema

This study tests alpelisib, a drug that targets a specific gene mutation (PIK3CA), in people with lymphatic malformations—abnormal growths of lymph vessels. The trial includes children and adults and compares alpelisib to a placebo to see if it can shrink the growths and ease sym…

This phase 3 trial compares a once-weekly growth hormone injection (lonapegsomatropin) to a daily one (somatropin) in 186 prepubertal children with growth failure due to Turner syndrome, SHOX deficiency, being small for gestational age, or idiopathic short stature. The goal is to…

This pilot study tests whether a surgical procedure called lymphovenous bypass (LVB) can prevent lymphedema (chronic swelling) when done at the same time as lymph node removal in melanoma patients. About 20 adults with melanoma who need axillary or inguinal lymph node dissection …

This Phase 2 study tests an oral drug called RLY-2608 in adults and children with overgrowth conditions (like CLOVES or Klippel-Trenaunay syndrome) caused by PIK3CA gene mutations. The drug is designed to block the faulty protein driving abnormal tissue growth. The trial will enr…

This study tests a new dye called Magtrace that stays in the lymph nodes for weeks. For women with non-invasive breast cancer (DCIS) having a mastectomy, this dye may allow doctors to safely delay lymph node removal until after the breast tissue is checked for hidden invasive can…

This study compares two microsurgical techniques (LVA and VLNT) against standard conservative therapy for chronic arm swelling after breast cancer treatment. Researchers will measure quality of life in 280 participants one year after surgery. The goal is to see if surgery provide…

This early study tests whether a robot can safely perform microsurgery on deep neck lymph nodes in 15 people with mild-to-moderate Alzheimer's. The idea is that clearing blockages in these lymph nodes might help the brain remove harmful waste. The main goal is to check safety, no…

This study tests a bone marrow transplant from a family donor for children under 21 with severe non-cancer blood disorders like sickle cell disease, bone marrow failure, or immune problems. The goal is to see if the transplant can replace the diseased cells with healthy donor cel…

This study tests whether the drug rapamycin can shrink large, hard-to-treat lymphatic malformations in the head and neck area of children. Over 6 months, 28 kids will take oral rapamycin, and doctors will measure changes using MRI scans and quality-of-life surveys. The goal is to…

This study tests an injected medicine called TARA-002 for children aged 6 months to 18 years who have lymphatic malformations (fluid-filled cysts). The goal is to see if the injections can safely shrink or eliminate the cysts. Up to 38 children will receive up to 4 injections, ea…

This study tests vosoritide, a protein that stimulates bone growth, in 30 children with Noonan syndrome who are not growing well despite growth hormone treatment. The goal is to see if vosoritide can safely increase their growth rate over six months. Participants will receive one…

This phase 2 trial is testing whether a less extensive lymph node surgery, called targeted axillary dissection (TAD), can safely control cancer in women aged 45 and older with early-stage ER+ breast cancer that has spread to lymph nodes detected by ultrasound. Participants will h…

This phase 2 trial is testing two targeted drugs—alpelisib and mirdametinib—in 50 people with slow-flow or fast-flow vascular malformations that haven't responded to standard treatments. The goal is to see if these drugs can improve each person's most bothersome symptom over 48 w…

This study is testing a robotic system called Symani to help surgeons perform delicate microsurgery for two types of procedures: free tissue transfer (moving tissue from one part of the body to another) and lymphatic surgery (to treat lymphedema, a condition causing swelling). Ab…

This study is testing the Symani Surgical System, a robotic device designed to help surgeons perform very delicate microsurgeries. The trial will include 455 adults undergoing free tissue transfer or lymphedema surgery. Researchers will check how well the robot works for reconnec…

This study tests whether taking the drug sirolimus just once a week can safely treat venous and lymphatic malformations—abnormal clusters of blood vessels or lymph vessels that can cause pain and swelling. Current daily dosing works but often causes side effects like low white bl…

This study tests whether a special dye (indocyanine green) that glows under a special camera can help surgeons better see and remove cystic lymphatic malformations in children. About 110 children will be randomly assigned to either standard surgery or surgery guided by this dye. …

This phase 2 trial tests whether pravastatin (a cholesterol drug) or a combination of pentoxifylline and vitamin E can prevent lymphedema and fibrosis (swelling and scarring) caused by radiation therapy in head and neck cancer patients. About 295 adults with oropharyngeal cancer …

This study tests a systematic approach for treating orbital lymphatic malformation in children aged 1-18. Participants are split into three groups: one gets sclerotherapy (injections to shrink the lesion), one gets the drug sirolimus, and one gets both. The goal is to see if siro…

This phase 2 trial tests several medications—including pravastatin, pentoxifylline, and others—to see if they can treat or prevent lymphedema and fibrosis caused by radiation therapy in head and neck cancer survivors. About 250 participants who have finished radiation at least 6 …

This study tests whether adding a special collagen thread called BioBridge to standard lymph node transfer surgery can better reduce arm swelling in people with lymphedema. About 60 adults with stage I-II arm lymphedema will be followed for 12 months to measure changes in limb vo…

This study tests whether a ketogenic diet or ketone supplements can improve lymphatic function in people with lymphedema, a condition causing arm swelling after lymph node removal. 81 participants will be randomly assigned to a ketogenic diet, an isocaloric diet, or ketone supple…

This early-stage study is testing a special radioactive tracer called 18F-FTHA that can be seen on PET scans. The goal is to learn how this tracer travels through the lymphatic system in healthy volunteers and in people with suspected blockages in the main lymph duct. The study w…

This study uses special ultrasound techniques to find clear differences between lymphedema and lipedema, two chronic conditions that cause leg swelling and are often hard to tell apart. Researchers will compare 75 adults—those with lymphedema, those with lipedema, and healthy vol…

This study tests a new type of ultrasound called super-resolution ultrasound (SRUS) to see if it can better tell the difference between benign (non-cancerous) and malignant (cancerous) swollen lymph nodes. About 779 adults with abnormal lymph nodes will receive an injection of ul…

This study tests a low-risk surgical procedure called LYMPHA, done at the same time as breast cancer lymph node removal, to prevent lymphedema—a chronic, painful arm swelling. About 80 women undergoing breast cancer surgery will be randomly assigned to receive LYMPHA or standard …

This study looks at whether doing a lymphovenous bypass procedure at the same time as lymph node removal surgery can prevent lymphedema (chronic leg swelling). Twenty adults having groin lymph node surgery will get the bypass and be followed for 2 years. The main goal is to see i…

This study tests whether a procedure called lymphovenous bypass, done before underarm lymph node removal, can prevent lymphedema (arm swelling) in patients with breast cancer or melanoma. About 252 participants will receive the bypass during their cancer surgery. Researchers will…

This study tests a procedure called Immediate Lymphatic Reconstruction (ILR) done during breast cancer surgery to prevent lymphedema, a painful arm swelling. About 98 high-risk women will be randomly assigned to receive ILR or standard care. Researchers will track who develops ly…

This study tests if repairing the lymphatic system during breast cancer surgery can prevent lymphedema, a painful arm swelling. 50 women with breast cancer will receive this reconstruction. The goal is to see if this approach reduces the risk of developing lymphedema.

This study tests a surgical technique called immediate lymphatic reconstruction (ILR) done at the same time as lymph node removal for cancer. The goal is to reconnect tiny lymph channels to nearby veins to prevent lymphedema, a painful arm swelling. Researchers will measure arm s…

This study tests a surgical procedure called immediate lymphatic reconstruction (ILR) done at the same time as lymph node removal in breast cancer patients. The goal is to prevent lymphedema, a painful arm swelling that can occur after surgery. Researchers will follow 100 women t…

This study tests a surgery called lymphovenous bypass (LVB) to prevent lymphedema—painful arm swelling—in breast cancer patients who had lymph nodes removed. About 136 participants will either get LVB plus physiotherapy or physiotherapy alone. The goal is to see if the surgery re…

This study tests whether a comprehensive program can prevent lymphedema (chronic arm swelling) in women undergoing lymph node removal for breast cancer. The program includes immediate lymphatic reconstruction during surgery, self-directed lymphatic massage, and regular arm measur…

This study tests a light-based treatment (photobiomodulation) to reduce long-term swelling in the head and neck area caused by cancer therapy. It involves 150 adult survivors who have had head and neck cancer and still have swelling for at least 6 months. Participants will receiv…

This study compares a newer painkiller called oliceridine with two standard drugs, morphine and sufentanil, for pain relief after lumbar spine surgery. Ninety adults will receive one of the three drugs through a patient-controlled pump. The main goal is to see how well each drug …

This study looks at two types of nerve blocks given before mastectomy to see which one better prevents chronic pain. About 132 adults having a mastectomy will be randomly assigned to receive either an erector spinae block or a paravertebral block. Researchers will track pain, opi…

This study compares two ways to treat breast cancer that has spread to nearby lymph nodes: targeted radiotherapy or surgical removal of the nodes. The goal is to see which approach better preserves arm function and reduces the risk of long-term arm swelling. About 1,060 adults wi…

This study tests if combining resisted deep breathing exercises with a special massage technique (myofascial release) can reduce pain, improve breathing, chest movement, and arm swelling in people who have had a mastectomy. The study will include 48 adults who are at least 6 mont…

This study looks at whether doing resistance exercises (like leg presses) can reduce swelling in the lower legs of people with lymphedema. It also checks if wearing compression garments during exercise makes a difference. Thirty-six adults with lower limb lymphedema will exercise…

This study is testing a new portable device called Dayspring that uses active compression to reduce leg swelling from lymphedema or phlebolymphedema. It will involve 100 veterans and measure cost savings, mobility, and symptom severity. The device is non-pneumatic, meaning it doe…

This study tests whether two non-invasive therapies—extracorporeal shock wave therapy and pulse electromagnetic field therapy—can reduce swelling and improve quality of life in people with lymphedema after cancer treatment. Ninety participants will receive one of the therapies or…

This study tests whether a supplement called MyCondro can help people with knee osteoarthritis move better and feel less joint discomfort. Researchers will give two different doses to 240 adults aged 45 and older who have had knee problems for at least six months. The main goal i…

This study tests whether adding virtual reality (VR) exercises to standard therapy can improve walking, reduce leg swelling, and boost quality of life in people with lower limb lymphedema. Forty adults with stage 2 or 3 lymphedema after cancer surgery will either receive standard…

This study tests if progressive resistance exercise can improve arm swelling and function in people who developed lymphedema after breast cancer treatment. Fifty adults aged 18-60 who are at least 3 months past surgery will be enrolled. Participants will do supervised exercises a…

This study compares two types of nerve blocks (pectoral nerve block vs. paravertebral block) given during mastectomy to see which better prevents chronic pain. Ninety women aged 20-65 undergoing mastectomy will be randomly assigned to one of the two blocks. The goal is to reduce …

This study tests whether adding aerobic exercise to standard lymphedema therapy (complex decongestive physiotherapy) can improve walking, balance, leg strength, and daily function. Twenty-four adults with bilateral lower limb lymphedema will be randomly assigned to either standar…

This study tests whether Acceptance and Commitment Therapy (ACT), delivered through a smartphone app, can help caregivers of children with RASopathies (like Neurofibromatosis type 1 and Noonan syndrome) cope with parenting stress. The trial is fully remote and involves 70 adult c…

This study tests a surgery called lymphaticovenous anastomosis (LVA) to see if it reduces chronic swelling (lymphedema) in cancer survivors. About 110 people with swelling in one arm or leg after cancer treatment will be randomly assigned to receive either LVA or a sham surgery. …

This study tests a special massage technique called 'Gentle Touch' to see if it can reduce arm swelling (lymphedema) in women who had breast cancer surgery. Thirty-six women aged 30 to 75 will receive either Gentle Touch or standard care twice a week for five weeks. The goal is t…

This study compares two standard pain-block methods for people having a mastectomy (breast removal) due to breast cancer or high risk. One method uses a nerve block before surgery, the other during surgery. The goal is to see which approach reduces the need for opioid painkillers…

This study tests whether a special massage called manual lymph drainage can help reduce swelling in the face and neck caused by radiation therapy for head and neck cancer. The study will include 40 people who have finished radiation within the past year. It compares two different…

This study tests whether adding kinesio tape to standard therapy helps women with long-term breast or trunk swelling after breast cancer treatment. About 128 participants will receive either standard care alone or standard care plus kinesio tape for four weeks. Researchers will m…

This study looks at how people's immune systems react to infections from parasitic worms, which can cause serious health problems like swelling, blindness, or heart disease. Researchers will evaluate and treat up to 500 participants aged 3 to 100 using standard medical tests and …

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll up to 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and healthy volun…

This natural history study aims to collect data from 1,200 people with lymphatic anomalies—rare conditions affecting the body's lymph system—over many years. Researchers will track symptoms, perform genetic testing, and gather biospecimens to better understand why these condition…

This study looks for better ways to detect lung inflammation and infections early in people who have received a stem cell transplant from a donor. About 40 participants aged 5 to 70 will get regular lung scans, breathing tests, blood draws, and a procedure where a tube collects f…

This study aims to discover new genes that may cause certain cancers to run in families. Researchers will collect blood samples and health information from 1,500 people in families where multiple members have had cancer, especially childhood cancers. The goal is to build a regist…

This study looks at how to reduce the long and frustrating journey to a diagnosis for people with developmental abnormalities. Researchers will review past cases, collect new blood or skin samples, and use advanced genetic testing. The goal is to understand why some people remain…

This study aims to learn more about RASopathies, a group of genetic conditions that can cause developmental issues, birth defects, and increased cancer risk. Researchers will follow up to 500 people of any age who have or may have a RASopathy, along with their family members, for…

This study follows 1,250 women who have had lymph node removal during breast cancer surgery. Researchers use arm measurements and tissue tests to see who develops lymphedema (arm swelling) and why. The goal is to find early warning signs and improve quality of life.

This study explores whether a device that sends a tiny, safe electrical current through the body can better track fluid retention (edema) in cancer patients. Researchers will measure 46 people—breast cancer patients with arm swelling after radiation and others with leg swelling a…

This study is creating a registry of up to 1,000 people with rare lymphatic system disorders. Researchers will collect information from medical records and yearly surveys to understand how these diseases progress, what treatments are used, and how they affect quality of life. The…

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This study aims to create a collection of blood and urine samples from 100 people with Noonan syndrome. Researchers will use these samples to study how the disease works and look for factors that predict how it will progress. The study does not test any treatment, but may help gu…

This study follows 100 women with early-stage breast cancer for two years after surgery and treatment. Researchers will measure changes in muscle mass, body fat, and strength using simple tests. The goal is to understand how the body recovers and what factors affect quality of li…

This study follows 400 pregnant women with rare blood vessel diseases (like HHT, Marfan syndrome, or lymphedema) to learn about serious pregnancy complications. Researchers will ask participants about their health during pregnancy and for 12 months after birth. The goal is to gat…

This study looks at cholesterol and blood sugar levels in 200 people with Noonan syndrome and related conditions, aged 2 to 35. Researchers want to see if these levels differ by age, gender, or genetic type. The goal is to improve long-term care by identifying who might be at hig…

This study looks at the emergency and disaster plans of about 319 German hospitals to see how well they are prepared for crises. Researchers will compare the plans to find common strengths, weaknesses, and best practices. The goal is to help hospitals improve their emergency plan…

This study is creating a large registry of 800 people receiving biologic medications for immune conditions like autoimmune diseases and primary immune deficiencies. Researchers will collect blood samples and health data to better understand how these treatments work and who respo…

This study is testing advanced heart MRI scans to better diagnose and predict risks for people with rare heart muscle diseases. Researchers will scan 1000 participants to see if these new imaging methods can identify conditions like Fabry disease and cardiac amyloidosis more accu…

This study is a large European registry that will observe up to 500 patients with lymphatic disorders related to congenital heart disease. Researchers will collect data on current diagnostic imaging and treatments like lymphatic embolization to see which approaches improve sympto…

This study will test 10,000 people in Cambodia for 57 different infectious diseases, including dengue, flu, and malaria. Researchers want to understand how these diseases spread and who is at risk. The goal is to give local health authorities the information they need to create b…

This study follows 400 patients who have had urologic cancer surgery with lymph node removal to see how often they develop lymphedema (leg swelling). Researchers will use questionnaires and special devices to measure swelling and tissue fluid over two years. The goal is to better…

This study aims to understand why lymphedema develops by comparing gene activity in swollen versus healthy limbs. Researchers will take tiny tissue samples from 60 adults with primary or secondary lymphedema. The goal is to identify molecular differences that could point toward f…

This study follows 10,000 breast cancer patients to detect lymphedema—arm swelling that can occur after treatment—as early as possible. Researchers use arm measurements and patient surveys to track changes in symptoms, function, and quality of life. The goal is to improve outcome…

This study watches how the lymphatic system changes after radiation therapy in 40 women with breast cancer. Researchers use a safe dye and special camera to see early signs of arm swelling (lymphedema). The goal is to find ways to predict and prevent this side effect in the futur…

This study is collecting blood, tissue, and medical information from up to 1,000 people with RASopathies—a group of genetic conditions that affect development and raise cancer risk. Researchers will store these samples and data in a database for future studies. The goal is to lea…

This study is creating a collection of blood, urine, and stool samples from 500 adults with or at risk for heart and blood vessel diseases. Researchers will use these samples to study inflammation, blood clotting, and other biological pathways. The goal is to build a resource tha…

This study checks if people with lymphedema have higher levels of lipoprotein(a), a substance linked to heart disease. Researchers will test blood from 100 adults with lymphedema to see how common high LP(a) is. The goal is to learn if lymphedema patients need extra heart risk mo…

This study looks at 48 people with chronic leg swelling to find out why some respond to compression therapy and others don't. Participants will have an MRI and genetic testing to measure fat, muscle, and fluid in their legs. The goal is to better understand the condition, not to …

This study follows 600 people with lymphedema to compare quality of life between those who choose surgery (a lymph node transfer) and those who choose non-surgical management. Participants fill out questionnaires about their symptoms and daily life over time. The goal is to under…