Weekly shot could replace daily growth hormone for kids

NCT ID NCT07221851

Recruiting now Disease control Sponsor: Ascendis Pharma A/S Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial compares a once-weekly growth hormone injection (lonapegsomatropin) to a daily one (somatropin) in 186 prepubertal children with growth failure due to Turner syndrome, SHOX deficiency, being small for gestational age, or idiopathic short stature. The goal is to see if the weekly shot works as well as the daily one for increasing height. Participants will receive either weekly treatment for 2 years or daily treatment for 1 year followed by weekly treatment for 1 year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

lonapegsomatropin (once-weekly injection) and somatropin (daily injection)

What this could lead to

If successful, this could offer children with growth disorders a more convenient once-weekly injection instead of daily shots, potentially improving adherence and quality of life.

What could go wrong

This is a phase 3 trial, but it is still relatively small (186 participants) and open-label, which can introduce bias. The weekly treatment may not prove as effective as daily injections for all conditions studied.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

chromosomal disorder Dwarfism endocrine system disorder Failure to Thrive fetal growth restriction isolated short stature Noonan syndrome sex chromosome disorder of sex development Sex Chromosome Disorders SHOX-related short stature Turner syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IDIOPATHIC SHORT STATURE SHORT STATURE HOMEOBOX GENE MUTATION SMALL FOR GESTATIONAL AGE AT DELIVERY TURNER SYNDROME

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Ascendis Pharma Investigational Site
RECRUITING

Palo Alto, California, 94304, United States
Ascendis Pharma Investigational Site
RECRUITING

Sacramento, California, 95821, United States
Ascendis Pharma Investigational Site
RECRUITING

Centennial, Colorado, 80112, United States
Ascendis Pharma Investigational Site
RECRUITING

Orlando, Florida, 32806, United States
Ascendis Pharma Investigational Site
RECRUITING

St. Petersburg, Florida, 33701, United States
Ascendis Pharma Investigational Site
RECRUITING

Atlanta, Georgia, 30329, United States
Ascendis Pharma Investigational Site
RECRUITING

Idaho Falls, Idaho, 83404, United States
Ascendis Pharma Investigational Site
RECRUITING

New Orleans, Louisiana, 70118, United States
Ascendis Pharma Investigational Site
RECRUITING

Minneapolis, Minnesota, 55454, United States
Ascendis Pharma Investigational Site
RECRUITING

Saint Paul, Minnesota, 55102, United States
Ascendis Pharma Investigational Site
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
Ascendis Pharma Investigational Site
RECRUITING

San Antonio, Texas, 78229, United States
Ascendis Pharma Investigational Site
RECRUITING

San Antonio, Texas, 78232, United States
Ascendis Pharma Investigational Site
RECRUITING

Toulouse, 31300, France
Ascendis Pharma Investigational Site
RECRUITING

Hanover, 30173, Germany
Ascendis Pharma Investigational Site
RECRUITING

Naples, 80131, Italy
Ascendis Pharma Investigational Site
RECRUITING

Sejong, 30099, South Korea
Ascendis Pharma Investigational Site
RECRUITING

Seoul, 03722, South Korea
Ascendis Pharma Investigational Site
RECRUITING

Seoul, 05505, South Korea
Ascendis Pharma Investigational Site
RECRUITING

Seoul, 06273, South Korea
Ascendis Pharma Investigational Site
RECRUITING

Barcelona, 8950, Spain
Ascendis Pharma Investigational Site
RECRUITING

Madrid, 28046, Spain
Ascendis Pharma Investigational Site
RECRUITING

Málaga, 29011, Spain
Ascendis Pharma Investigational Site
RECRUITING

Zaragoza, 50009, Spain
Ascendis PharmaInvestigational Site
RECRUITING

Le Kremlin-Bicêtre, 94270, France