Massive study launches to unravel mysteries of rare lymphatic diseases

NCT ID NCT05731141

Recruiting now Knowledge-focused Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 5 times

Summary

This natural history study aims to collect data from 1,200 people with lymphatic anomalies—rare conditions affecting the body's lymph system—over many years. Researchers will track symptoms, perform genetic testing, and gather biospecimens to better understand why these conditions develop. The goal is to improve future treatments, not to test a new therapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could provide crucial insights into how lymphatic anomalies develop and progress, paving the way for better treatments in the future.
What could go wrong: This is an observational study, not a treatment trial, so there is no direct benefit to participants. It may take many years to gather enough data to influence clinical practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chylous ascites lymphangiectasis Lymphatic Abnormalities lymphatic malformation lymphatic system disorder lymphedema Osteolysis, Essential protein-losing enteropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LYMPHATIC ABNORMALITIES LYMPHATIC DISEASES

Contacts and locations

Locations

Children's Hospital of Philadelphia
NOT_YET_RECRUITING

Philadelphia, Pennsylvania, 19104, United States
National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

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