Protein-losing enteropathy
MONDO:0009174Pathological conditions in the intestines that are characterized by the gastrointestinal loss of serum proteins, including serum albumin; immunoglobulins; and at times lymphocytes. Severe condition can result in hypogammaglobulinemia or lymphopenia. Protein-losing enteropathies are associated with a number of diseases including intestinal lymphangiectasis; whipple'S disease; and neoplasms of the small intestine.
Also known as: protein-losing enteropathy, protein-losing enteropathy (disease), CHAPLE, complement hyperactivation, ANGIOPATHIC thrombosis, and PROTEIN-losing enteropathy, complement hyperactivation, Angiopathic thrombosis, and Protein-losing enteropathy, enteropathy, PROTEIN-losing
11 clinical trials for this condition and its sub-types.
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New drug hopes to tame rare Gut-Heart disease in toddlers
Disease control Recruiting nowThis study tests a drug called pozelimab in children aged 1 to 5 who have CHAPLE disease, a very rare genetic condition that causes severe stomach and heart problems. The main goal is to see if the drug is safe and how it affects the body. Only 5 children will take part, and the …
Phase: PHASE4 • Sponsor: Regeneron Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC
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Genetic showdown: can full genome sequencing outsmart rare gut disease?
Diagnosis Recruiting nowThis study tests whether whole genome sequencing (looking at all DNA) finds more answers than whole exome sequencing (looking at just the protein-making parts) for children with long-lasting diarrhea and gut problems. About 180 children will be randomly assigned to one test or th…
Phase: NA • Sponsor: Children's Hospital of Fudan University • Aim: Diagnosis
Last updated Jun 27, 2026 12:00 UTC
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Massive study launches to unravel mysteries of rare lymphatic diseases
Knowledge-focused Recruiting nowThis natural history study aims to collect data from 1,200 people with lymphatic anomalies—rare conditions affecting the body's lymph system—over many years. Researchers will track symptoms, perform genetic testing, and gather biospecimens to better understand why these condition…
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:02 UTC
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NIH launches massive GI data bank to fuel future discoveries
Knowledge-focused Recruiting nowThis study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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500-Patient registry aims to unlock better care for rare lymphatic disorders
Knowledge-focused Recruiting nowThis study is a large European registry that will observe up to 500 patients with lymphatic disorders related to congenital heart disease. Researchers will collect data on current diagnostic imaging and treatments like lymphatic embolization to see which approaches improve sympto…
Sponsor: Rigshospitalet, Denmark • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC