Protein-losing enteropathy
MONDO:0009174Pathological conditions in the intestines that are characterized by the gastrointestinal loss of serum proteins, including serum albumin; immunoglobulins; and at times lymphocytes. Severe condition can result in hypogammaglobulinemia or lymphopenia. Protein-losing enteropathies are associated with a number of diseases including intestinal lymphangiectasis; whipple'S disease; and neoplasms of the small intestine.
Also known as: protein-losing enteropathy, protein-losing enteropathy (disease), CHAPLE, complement hyperactivation, ANGIOPATHIC thrombosis, and PROTEIN-losing enteropathy, complement hyperactivation, Angiopathic thrombosis, and Protein-losing enteropathy, enteropathy, PROTEIN-losing
8 clinical trials for this condition and its sub-types.
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Experimental drug offered to patients with rare gut condition
Disease control ApprovedThis study provides compassionate access to pozelimab for people with CD55-deficient protein-losing enteropathy, a rare condition where the gut leaks proteins. The goal is to offer an experimental treatment option when no other therapies are available. Participants receive the dr…
Sponsor: Regeneron Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 07:57 UTC
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Lifesaving drug now available for kids with rare gut disease
Disease control ApprovedThis program gives patients with CHAPLE disease, a rare and life-threatening immune disorder that causes protein loss from the gut, access to the experimental drug pozelimab. The goal is to provide treatment and monitor long-term safety. Participants must have a confirmed genetic…
Sponsor: Regeneron Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC