Less invasive breast cancer surgery could reduce lymphedema risk
NCT ID NCT06092892
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial is testing whether a less extensive lymph node surgery, called targeted axillary dissection (TAD), can safely control cancer in women aged 45 and older with early-stage ER+ breast cancer that has spread to lymph nodes detected by ultrasound. Participants will have breast surgery (lumpectomy or mastectomy) with TAD, followed by radiation therapy. The study will track how many women have cancer come back in the lymph nodes or breast over time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Breast surgery (lumpectomy or mastectomy) with targeted axillary dissection and sentinel node biopsy, plus adjuvant radiation therapy
What this could lead to
If successful, this approach could offer a less invasive surgical option for women with early ER+ breast cancer that has spread to nearby lymph nodes, potentially reducing side effects like lymphedema.
What could go wrong
This is a small, early-phase trial with only 45 participants and no comparison group. It is not yet known if this approach is as effective as standard treatment, and there is a risk of cancer recurrence in the lymph nodes or breast.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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CS Cancer at Huntington Cancer Center
RECRUITINGPasadena, California, 91105, United States
Contact Phone: •••-•••-••••
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CS Cancer at Valley Oncology Medical Group
RECRUITINGTarzana, California, 91356, United States
Contact
Contact Email: •••••@•••••
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Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute
RECRUITINGLos Angeles, California, 90048, United States
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Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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