Less invasive breast cancer surgery could reduce lymphedema risk

NCT ID NCT06092892

Recruiting now Disease control Sponsor: Alice Chung Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 11, 2026 · Updated 3 times

Summary

This phase 2 trial is testing whether a less extensive lymph node surgery, called targeted axillary dissection (TAD), can safely control cancer in women aged 45 and older with early-stage ER+ breast cancer that has spread to lymph nodes detected by ultrasound. Participants will have breast surgery (lumpectomy or mastectomy) with TAD, followed by radiation therapy. The study will track how many women have cancer come back in the lymph nodes or breast over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Breast surgery (lumpectomy or mastectomy) with targeted axillary dissection and sentinel node biopsy, plus adjuvant radiation therapy
What this could lead to: If successful, this approach could offer a less invasive surgical option for women with early ER+ breast cancer that has spread to nearby lymph nodes, potentially reducing side effects like lymphedema.
What could go wrong: This is a small, early-phase trial with only 45 participants and no comparison group. It is not yet known if this approach is as effective as standard treatment, and there is a risk of cancer recurrence in the lymph nodes or breast.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm female breast carcinoma hormone receptor-positive breast cancer lymphedema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AXILLA; BREAST AXILLARY NODAL DISEASE BREAST CANCER FEMALE BREAST CANCER MASTECTOMY; LYMPHEDEMA TUMOR, BREAST

Contacts and locations

Locations

CS Cancer at Huntington Cancer Center
RECRUITING

Pasadena, California, 91105, United States
CS Cancer at Valley Oncology Medical Group
RECRUITING

Tarzana, California, 91356, United States
Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute
RECRUITING

Los Angeles, California, 90048, United States

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