Lymphedema

This study will test the Symani Surgical System, a robotic device designed to help surgeons perform delicate microsurgery on lymph vessels in the head and neck. The goal is to see if the robot can safely and effectively reconnect lymph channels to reduce swelling (lymphedema) in …

This study compares two injected drugs, bleomycin and doxycycline, to treat lymphatic malformations (abnormal fluid-filled sacs) in children under 12. About 92 kids will be randomly assigned to one treatment, and doctors will measure how much the malformation shrinks over six mon…

This Phase 3 trial tests an oral drug called KP-001 in 150 people aged 2 and older with venous malformations, lymphatic malformations, or KTS/CLOVES syndrome. Participants receive either KP-001 or a placebo for 24 weeks, then everyone gets the drug for another 28 weeks. The goal …

This large study in Fiji tests whether a new combination of drugs (moxidectin plus two others) can safely treat three common parasitic infections: lymphatic filariasis, scabies, and strongyloidiasis. About 5,100 people will receive either the new combo or the standard treatment o…

This study tests whether a mobile app using artificial intelligence can help frontline health workers in sub-Saharan Africa better diagnose skin-related neglected tropical diseases, like leprosy and scabies. Researchers will collect images from dermatologists to train the AI, the…

This study will test a rapid finger-prick blood test for heart failure in 618 people with leg swelling (lymphoedema) who have not been diagnosed with heart failure. The test measures a substance called NT-proBNP and gives results in 12 minutes, compared to the usual lab test that…

This study tests whether a device that delivers sound waves (shock wave therapy) can help reduce leg swelling and improve quality of life in people with lower limb lymphedema. Thirty-six adults who are already using standard care will either get real or fake (sham) treatments twi…

This study tests if a new dynamic compression device, used with compression stockings, works as well as current treatments for reducing leg swelling in people with lymphedema. About 98 adults with stage II or III lymphedema will use either the new device or standard wraps and pum…

This study compares a new dynamic compression device to traditional bandages for reducing leg swelling in people with lymphedema. Over 5 days of intensive treatment, 110 participants will wear either the device or standard bandages. The goal is to see which method reduces excess …

This study tests whether a simple home exercise program done for at least three weeks before breast cancer surgery can help women recover better. 54 women with early-stage breast cancer will be randomly assigned to either the exercise program or usual care. Researchers will measu…

This study tests whether a daily 15-minute massage for 14 days can reduce swelling (lymphedema) and improve comfort in 40 premature babies in the NICU. Half the infants will receive standard care, and the other half will also get gentle massage on their arms and legs. Researchers…

This study tests whether a new adjustable sleeve called MOBIDERM Autofit works better than standard bandages for managing breast cancer-related lymphedema at night. Sixteen women with arm swelling will wear each device for one month to compare changes in arm volume and pressure. …

This study tests whether listening to positive self-affirmation audio recordings can help reduce pain, depression, anxiety, and stress in women who have had a mastectomy. Forty-two women will be randomly assigned to either listen to the affirmations or receive standard care. The …

This study compares two treatments for arm swelling (lymphedema) that can happen after breast cancer surgery. The goal is to see which therapy works better to reduce pain, swelling, and improve movement and quality of life. The study will include 52 women aged 30-60 who had a mas…

This study tests a 3-month exercise program for women with breast cancer who have arm swelling (lymphedema) and nerve pain (neuropathy) from treatment. Thirty women will do general and arm-specific exercises twice a week. Researchers will measure changes in arm size and pain leve…

This study will test whether special imaging scans (ICG lymphography and high-frequency ultrasound) can predict how well a surgery called lymphaticovenous anastomosis works for arm swelling after breast cancer treatment. Thirty women with mild to moderate lymphedema will be scann…

This pilot study tests whether a new compression pattern in a leg sleeve device (Flexitouch Plus) moves lymph fluid better than the current version. Five adults with leg lymphedema will receive both treatments in separate visits, and doctors will measure how far and how often lym…

This study will test a specially trained AI model (like ChatGPT) to see if it can help doctors correctly diagnose and recommend treatments for lymphedema, lipedema, and venous insufficiency. Researchers will compare the AI's suggestions to current medical guidelines. The goal is …

This study looks at why people with Noonan syndrome often bleed easily, especially from the skin, mouth, or nose. Researchers will compare a simple questionnaire about bleeding history with blood tests in 100 patients. The goal is to find better ways to predict serious bleeding, …

This study will test a new way to care for people in Ghana who have both a neglected tropical skin disease (like leprosy or Buruli ulcer) and mental health challenges like depression or anxiety. Researchers will work with 200 affected adults and local health workers to create a G…