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Pedaling away swelling: could cycling boost leg lymphedema treatment?

NCT ID NCT07726277

Symptom relief Sponsor: Bursa Yuksek Ihtisas Training and Research Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 24, 2026 · Last updated Jul 24, 2026

Summary

This trial tests whether adding aerobic exercise (cycling on a recumbent bike) to standard complete decongestive therapy can improve muscle thickness, balance, mobility, and quality of life in adults with lower extremity lymphedema. Participants will exercise 20–30 minutes per session, five days a week for four weeks. The study aims to fill a gap in research, which has mostly focused on arm lymphedema and simple limb measurements.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
aerobic exercise using a recumbent cycle ergometer
What this could lead to
If it works, adding aerobic exercise to standard lymphedema therapy could improve mobility, balance, and daily function for people with leg swelling.
What could go wrong
This is a small, short-term trial (50 people, 4 weeks). Results may not apply to all patients, and exercise may not provide added benefit over standard care alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of lower extremity lymphedema (unilateral or bilateral) * Age ≥18 years * Absence of cognitive impairment * Provision of written informed consent to participate in the study Exclusion Criteria: * Cognitive impairment * Presence of general contraindications to exercise (e.g., hemodynamic instability, uncontrolled hypertension, decompensated heart failure, recent myocardial infarction, or unstable angina pectoris) * Presence of neurological diseases affecting the lower extremities that would preclude participation in the exercise program * Presence of unhealed fractures in the lower extremities preventing exercise therapy * Active systemic infection or local infection in the treatment area, such as cellulitis, erysipelas, or thrombophlebitis in the lower extremities * Acute venous thromboembolic events involving the lower extremities * Heart failure or renal failure that may cause lower extremity edema * Presence of concomitant lipedema * Presence of venous insufficiency * Ongoing chemotherapy or radiotherapy (among patients with malignancy-related lymphedema) * Pregnancy

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Conditions

The condition(s) this trial relates to.

lymphedema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lower extremity lymphedema

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

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