Lymphedema

This study looked at whether the HPV vaccine works in girls aged 9 to 17 who are taking medicines that weaken their immune system, such as after an organ transplant or for diseases like lupus. The goal was to see if their bodies produce enough antibodies to protect against HPV. T…

This study looked at how well a robotic system called Symani helps surgeons perform very precise reconstructive surgeries on small blood vessels, lymph vessels, and nerves. It included 427 adults who needed this type of surgery after cancer, injury, birth defects, or for lymphede…

This study tested a daily pill called acebilustat in 40 adults with long-term arm lymphedema (stage 2, lasting over 6 months). Participants took either the drug or a placebo for 9 months, with the first 3 months on placebo for all. The main goal was to see if the drug reduces ski…

This study tested injecting bleomycin directly into cystic hygromas (fluid-filled birthmarks) in 30 children aged 1 month to 12 years. The fluid was drained and bleomycin injected, repeated every 4 weeks until the lump shrank. Most children saw significant size reduction, with so…

This early-phase trial tested a combination of three drugs—vemurafenib, cetuximab, and irinotecan—in 47 people with advanced solid tumors that have a specific BRAF V600 mutation and could not be removed by surgery or had spread. The main goal was to find the safest dose and under…

This study looked at whether adding a special type of physiotherapy after lymphovenous anastomosis surgery helps people with lymphedema more than physiotherapy alone. Lymphedema is a condition where fluid builds up and causes swelling, often after cancer treatment. The study invo…

This phase 2 trial tested whether taking iohexol by mouth can treat chylous ascites, a leak of lymphatic fluid that can happen after abdominal or pelvic cancer surgery. The study enrolled 42 patients who developed this condition after surgery. The goal was to see if oral iohexol …

This study tested a cream containing sirolimus on rare skin growths called microcystic lymphatic malformations, which can ooze, bleed, and cause pain. 55 children and adults applied the cream to one area and a placebo cream to another for 12 weeks. The goal was to see if the siro…

This study tested whether a drug called moxidectin, combined with other medicines, works better than the standard treatment (ivermectin combinations) for lymphatic filariasis, a parasitic disease that can cause severe swelling. 164 adults with the infection received a single dose…

This massive study tested whether giving deworming medicine (albendazole) to everyone in a community, not just children, can break the cycle of soil-transmitted worm infections. Over 350,000 people in India, Malawi, and Benin took part. The goal was to see if treating entire vill…

This phase 2 trial tested the drug sirolimus (rapamycin) in 61 children and young adults with complicated vascular anomalies—abnormal blood vessel growths that can cause pain, bleeding, or organ problems. The goal was to see if sirolimus could safely shrink these anomalies and im…

This early-stage trial tested an oral drug called JAB-3312 in 40 adults with advanced solid tumors (like lung, colon, or breast cancer) that had stopped responding to standard treatments. The main goals were to find a safe dose and check for side effects. Researchers also looked …

This study looked at whether adding a device that applies gentle suction (negative pressure) to standard lymphedema therapy helps reduce arm swelling in women who developed lymphedema after cancer treatment. Eighteen participants received both standard therapy and the combined ap…

This study tested the DePuy LCS Complete mobile-bearing total knee system in 241 people needing knee replacement due to arthritis. The goal was to see how well the implant and surgical tools work during and after surgery. Researchers measured implant survival, knee function, and …

This study tested new adhesive sensors that stick to the skin to see if they can detect early signs of lymphedema, a painful arm swelling that can happen after cancer treatment. Researchers compared readings from 76 people with and without lymphedema. The goal is to create a simp…

This study tested small wearable sensors to see if they can accurately measure lymphedema, a condition where fluid builds up and causes swelling, often after cancer treatment. Thirty adults with arm lymphedema wore the sensors during one visit, and researchers compared the readin…

This study tested a device called Insight Pro to see if it can safely detect lymphatic and vein disorders, such as lymphedema and chronic venous insufficiency. The device measures fluid buildup and skin hardness in the arms or legs. A total of 67 adults with or without these cond…

This study looked at whether adding physical therapy to educational materials could prevent lymphedema (arm swelling) in women treated for breast cancer. Over 1,000 women who had lymph nodes removed were randomly assigned to receive either education alone or education plus a pers…

This study compared two painkillers, oliceridine and morphine, in 252 adults undergoing laparoscopic colorectal surgery. The goal was to see if oliceridine causes less nausea and vomiting after surgery. Patients used a pump to control their pain medicine for up to 3 days after th…

This study tested a new, standardized process for providing assistive devices (like special tools) to help people put on and take off compression stockings. 220 adults who need these stockings long-term took part. The goal was to see if the new method improves how often people us…

This study looked at whether closed kinetic chain and weight shifting exercises can improve balance and stability in women who have arm swelling (lymphedema) after a mastectomy. Sixty women aged 40-60 with moderate lymphedema participated. They did exercises designed to strengthe…

This study looked at whether adding a machine called LPG Cellu M6 to standard treatment helps reduce arm swelling (lymphedema) in breast cancer patients. About 93 people with moderate to severe swelling for at least 6 months took part. The goal was to see if more patients could r…

This study tested whether a special nursing plan (called ERAS) could help women recover after surgery for cervical cancer. 160 women were split into two groups: one got the ERAS nursing plan, the other got standard care. The goal was to see if the ERAS plan could lower the risk o…

This study tested two non-drug treatments—kinesio taping and low-level laser therapy—on 66 women with arm swelling (lymphedema) after mastectomy for stage II breast cancer. The goal was to see which method better reduced arm size, improved hand grip strength, and eased shoulder p…

This study looked at whether adding manual lymph drainage to standard compression therapy improves outcomes for people with lower leg lymphedema. Thirty-one participants were randomly assigned to receive either compression alone or compression plus manual lymph drainage. The rese…

This study looked at whether adding TECAR therapy or shock wave therapy to standard treatment (complex decongestive therapy) could better reduce leg swelling in severely obese women with lymphedema. Forty-five women took part, receiving one of three treatments over four weeks. Re…

This study tested whether an advanced pneumatic compression device (Flexitouch Plus) could reduce swelling and symptoms in 236 head and neck cancer survivors with lymphedema. Participants either used the device daily or received usual care like manual drainage and compression gar…

This study tested a wearable compression device called Dayspring for people with lymphedema in one leg. 24 adults used the device daily for 3 months. Researchers measured changes in leg swelling and quality of life to see if the device was safe and helpful.

This study looked at breast reconstruction using only a patient's own fat (lipomodulin) after mastectomy for breast cancer. Researchers wanted to see how often the procedure works, how the breast looks afterward, and how it affects quality of life. The study included 118 women wh…

This study looked at whether a home-based exercise program can help people with head and neck cancer maintain movement, muscle strength, and posture while undergoing radiation therapy. Twenty-four adults who had surgery and were scheduled for radiation took part. The goal was to …

This study tested a new vibrating device called LymphaVibe for treating arm lymphedema, a painful swelling from fluid buildup. Fifteen adults with lymphedema used the device for 40 minutes during a clinic visit. Researchers measured arm size, pain, and side effects before and aft…

This pilot study tested whether a 12-week program of special exercises combined with advanced compression garments could reduce arm swelling in breast cancer survivors with lymphedema. Sixty women with mild to moderate chronic lymphedema were enrolled. The goal was to see if the …

This study tested a new portable, non-pneumatic compression device (Dayspring) against a standard pneumatic compression device for treating leg lymphedema. 121 adults with leg swelling used each device for three months, with a month off in between. Researchers measured changes in…

This study compared a new wearable compression device (Dayspring) to a standard pneumatic pump for treating arm swelling caused by breast cancer treatment. Fifty adults with lymphedema used both devices in a crossover design. Researchers measured arm volume changes and quality of…

This study looked at whether starting a personalized exercise program before breast cancer surgery helps women recover better. Thirty female survivors followed the program for 12 months. The goal was to improve shoulder motion, reduce pain, and enhance daily function and quality …

This study tested a treatment called Complex Decongestive Therapy (CDT) for people with venous insufficiency, a condition where leg veins struggle to send blood back to the heart. Twenty-one adults received either CDT plus exercises or exercises alone. The goal was to see if CDT …

This study tested whether adding underwater electrical stimulation to standard therapy helps women with arm swelling after mastectomy. Sixty women received either standard therapy alone or standard therapy plus the electrical bath. The goal was to see if the combination reduced p…

This pilot study tested whether low-energy shock wave therapy can help people with axillary web syndrome, a common complication after breast cancer surgery that causes painful, tight cords under the arm. Twenty patients received four weekly sessions of shock waves to the affected…

This study looked at how four different drinks—two prebiotic sodas, regular Coca-Cola, and Diet Coke—affect hunger, blood sugar, insulin, and appetite hormones in healthy men aged 18-40. Ten participants visited the lab four times, each time drinking one of the beverages in a ran…

This study looked at whether nerve signals (called sympathetic skin response) are linked to how well women respond to standard lymphedema therapy after breast cancer surgery. Thirty women with lymphedema and thirty healthy women had nerve tests and filled out symptom questionnair…

This study tested whether focused questionnaires can detect lymphedema—a common complication after armpit lymph node removal—earlier than physical measurements like arm circumference. Researchers followed 101 breast cancer patients who had or were scheduled for axillary dissectio…

This study tested a mobile 3D scanning app to measure swelling (lymphedema) in the head and neck area. Lymphedema is a buildup of fluid that causes swelling, often after cancer treatment. The goal was to see if this simple scanning method could accurately measure swelling and tra…

This study looked at how breast cancer-related lymphedema (arm swelling) affects the way women walk. Researchers compared 40 women with lymphedema to healthy volunteers, measuring arm swelling, shoulder movement, grip strength, and walking patterns. The goal was to understand if …

This study looked at whether chemotherapy before breast cancer surgery causes extra fluid buildup in the arm, an early sign of lymphedema. Researchers measured 111 women's arm fluid before and after chemo using a special device. The goal was to understand how often this happens a…

This completed study created a French national registry for people with rare overgrowth syndromes caused by PIK3CA gene mutations. Researchers collected medical and genetic information from 28 patients to better understand these conditions and estimate how many people are affecte…

This study looked at 1,000 women who had breast reconstruction with implants right after mastectomy, followed by radiation therapy. Researchers compared two types of implants—polyurethane-covered and non-polyurethane-covered—to see which had fewer complications like capsular cont…

This study tested a new ultrasound device to measure skin stiffness (fibrosis) in people with lymphedema or venous insufficiency. Researchers compared results from 130 participants, including healthy volunteers, to see if the device could detect differences in skin hardness. The …

This study tested a new sensor (CIMON) to see if it can accurately measure how well compression bandages reduce leg swelling in people with chronic edema (long-term fluid buildup). Fifty-two adults with leg swelling who needed compression bandages took part. The sensor was placed…

This study looked at how children with Noonan syndrome process energy and sugar. Researchers measured insulin sensitivity in 20 children with the condition to see if they have unique metabolic traits. The goal was to better understand the disease, not to test a new treatment.

This completed study looked at 133 breast cancer patients to develop a way to predict who will get arm swelling (lymphedema) after lymph node removal surgery. Researchers examined patient characteristics, proteins, and genes to build a risk model. The goal is to help doctors iden…

This study looked at 111 people who had surgery for early-stage cervical or vulvar cancer to find out how many develop lower leg swelling (lymphedema). Researchers used a questionnaire to gather information, not to test any new treatment. The goal is to better identify who is at …

This study looked back at medical records of 172 people with lymphedema to compare two treatments: a device called LymphaTouch and manual lymphatic drainage (a type of massage). The goal was to see which one better reduced arm or leg swelling. Researchers measured limb size befor…

This study collected blood, saliva, stool, urine, and skin samples from 19 people with unknown or poorly understood immune system problems. The goal was to learn how different parts of the immune system work together. No treatments or drugs were tested. Participants were followed…

This study tested different doses of oliceridine, a painkiller, to find the amount that best prevents sudden rises in blood pressure and heart rate when a breathing tube is placed during anesthesia. Researchers enrolled 58 adults having elective surgery and adjusted doses based o…

This study looked at a questionnaire designed to measure how leg swelling (lymphedema) affects daily life. Researchers tested a French version for accuracy and checked if the Dutch version can track changes over time. Over 450 people with leg lymphedema filled out the questionnai…

This study looked at 50 people with head and neck cancer to see how often swelling (lymphedema) happens after treatment. Researchers measured fluid levels in the head and neck before and after cancer therapy and checked quality of life. The goal was to better understand the probl…

This completed observational study looked at 110 breast cancer patients to see if arm swelling (lymphedema) is linked to a specific type of muscle pain called myofascial pain syndrome. Researchers examined trigger points in key muscles and measured pain thresholds. The goal was t…