Could a new drug combo beat elephantiasis?
NCT ID NCT04410406
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a drug called moxidectin, combined with other medicines, works better than the standard treatment (ivermectin combinations) for lymphatic filariasis, a parasitic disease that can cause severe swelling. 164 adults with the infection received a single dose of one of four drug combinations. Researchers checked blood samples over 36 months to see if the parasites were cleared. The goal is to find a more effective single-dose treatment to help control and eventually eliminate the disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Moxidectin (Mox) 8 mg, Ivermectin (IVM) 200 µg/kg, Diethylcarbamazine (DEC) 6 mg/kg, Albendazole (ABZ) 400 mg
- What this could lead to
- If moxidectin combinations work better, this could offer a more effective single-dose treatment for lymphatic filariasis, reducing transmission and disease burden.
- What could go wrong
- This is a completed Phase 3 trial with 164 participants, so results are available but may not apply to all populations. The drugs can cause side effects like dizziness or allergic reactions, and long-term benefits are still being studied.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Regional Hospital of Agboville, Southern Cote d'Ivoire
Agboville, Côte d’Ivoire
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