Double antiviral attack: could two flu drugs beat one for vulnerable patients?
NCT ID NCT04712539
First seen Jun 25, 2026 · Last updated Jul 17, 2026 · Updated 3 times
Summary
This phase 2 trial tests whether combining two antiviral drugs, baloxavir and oseltamivir, works better than oseltamivir alone for severe flu in people with weakened immune systems (such as blood cancer patients or stem cell transplant recipients). The study will measure how quickly the virus clears and whether the combination reduces hospital stays or complications. 60 participants are being recruited at MD Anderson Cancer Center.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Baloxavir marboxil and oseltamivir
- What this could lead to
- If it works, this combination could offer a more effective treatment for severe flu in people with weakened immune systems, reducing hospital stays and complications.
- What could go wrong
- This is a small, early-phase trial (60 participants) in a very specific group (cancer or transplant patients). The combination may not work better than oseltamivir alone, and there is a risk of side effects or drug resistance.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
M D Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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