Flu vaccine showdown: which shot protects seniors best?

NCT ID NCT06029933

Recruiting now Prevention Sponsor: Kaiser Permanente Source: ClinicalTrials.gov ↗

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This study compares two flu vaccines—Fluad and Fluzone High-Dose—in adults aged 65 and older to see which is more effective at preventing lab-confirmed flu and related complications like pneumonia or heart issues. Researchers will look at health records from over a million seniors across several flu seasons. The goal is to find out if one vaccine offers better protection for older adults.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Adjuvanted quadrivalent inactivated influenza vaccine (Fluad) compared with high-dose quadrivalent inactivated influenza vaccine (Fluzone High-Dose)
What this could lead to: If one vaccine proves more effective, it could guide flu shot recommendations for older adults, potentially reducing flu-related hospitalizations and complications.
What could go wrong: This is an observational study, so results may be influenced by factors other than the vaccines themselves. Also, flu seasons vary, so findings may not apply to all years.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CARDIOVASCULAR EVENTS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Community-Acquired Pneumonia pneumonia influenza prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOVASCULAR EVENTS COMMUNITY-ACQUIRED PNEUMONIA INFLUENZA

Contacts and locations

Locations

Kaiser Permanente Northern California (entire region)
RECRUITING

Oakland, California, 94612, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.