COMMUNITY-ACQUIRED PNEUMONIA

This study tests whether giving a stronger blood thinner (heparin) to adults hospitalized with pneumonia can prevent serious complications like needing a breathing machine or dying. About 4,000 participants will be randomly assigned to receive either the blood thinner or standard…

This study looks at whether treating herpes simplex virus (HSV) with acyclovir helps people on breathing machines who have pneumonia. Almost half of these patients have HSV in their lungs, but it's unclear if treating it improves survival. The trial will randomly assign 616 parti…

This study tests whether giving the antibiotic clarithromycin early, based on a blood test result, can prevent pneumonia from worsening into sepsis. About 330 adults with community-acquired pneumonia who are at risk will receive either clarithromycin or a placebo. The goal is to …

This study tests whether a narrow-spectrum antibiotic (amoxicillin alone) works as well as a broader one (amoxicillin/clavulanate) for pneumonia in people aged 65 and older who are hospitalized but not in intensive care. The goal is to reduce unnecessary use of strong antibiotics…

This study compares two common antibiotics, azithromycin and doxycycline, in adults hospitalized with community-acquired pneumonia who are also receiving beta-lactam antibiotics. The goal is to see which one helps patients leave the hospital sooner and reduces complications. Abou…

This study tests whether adding trimodulin to standard care helps adults with severe community-acquired pneumonia who need a breathing machine. About 590 hospitalized patients will receive either trimodulin or a placebo. The main goal is to see if more patients survive at least 2…

This study looks at whether a 'watch and wait' strategy (giving antibiotics only if a child doesn't improve after 3 days) works as well as giving antibiotics right away for children with mild pneumonia. About 2,000 children will be randomly assigned to one of the two approaches. …

This study looks at whether having awake pneumonia patients lie on their stomachs (prone position) while receiving high-flow oxygen can reduce the need for a breathing tube. The trial involves 1078 adults in intensive care with community-acquired pneumonia (not COVID-19). The goa…

This study follows 1,000 adults who visit a fever clinic with a respiratory infection. Researchers will collect information on symptoms, lab tests, and chest scans at the start, then track their recovery and any complications over time. The goal is to better understand how these …

This study is testing whether a simple frailty scale can better predict serious outcomes like death or complications in older adults (65+) who come to the emergency room with pneumonia. Researchers will follow 150 patients to see if adding frailty information to standard pneumoni…

This study aims to learn how common community-acquired pneumonia is and what factors make people more likely to get it. Researchers will collect information from 20,000 adults, including their diagnosis, symptoms, treatments, and hospital stays. The goal is to better understand t…