COMMUNITY ACQUIRED PNEUMONIA

This study is testing if a 'watch and wait' strategy for antibiotics is as safe and effective as giving them right away for children with mild pneumonia. About 2,000 children, aged 1 to 6 years, will be randomly assigned to either get antibiotics immediately or only if they don't…

This large international trial is testing whether giving hospitalized pneumonia patients a stronger, therapeutic dose of a common blood thinner (heparin) is better than the standard preventive dose at keeping them out of intensive care and helping them survive. The study aims to …

This study aims to find out if a simpler, narrower-spectrum antibiotic (amoxicillin) works as well as a stronger, broader-spectrum one (amoxicillin/clavulanate) for treating community-acquired pneumonia in people aged 65 and older who are hospitalized outside the intensive care u…

This study aims to determine if treating herpes simplex virus (HSV) with the drug acyclovir helps critically ill pneumonia patients on ventilators survive. Researchers will randomly assign 616 ICU patients who have both pneumonia and HSV detected in their lungs to receive either …

This study compares two common antibiotics—azithromycin and doxycycline—for adults hospitalized with pneumonia. Researchers want to see which one helps patients spend fewer days in the hospital and recover faster. The trial includes 1,120 participants who are already receiving st…

This study is testing if a drug called trimodulin, when added to standard hospital care, can help adults with severe pneumonia who are on a breathing machine. The main goal is to see if it lowers the risk of death within 28 days. About 590 participants will be randomly assigned t…

This study is testing if giving an antibiotic called clarithromycin early to adults with pneumonia can prevent the infection from worsening into life-threatening sepsis. Doctors will use a specific blood test result to identify which pneumonia patients are at the highest risk for…

This study aims to learn more about how common respiratory infections like colds, flu, and pneumonia progress over time. Researchers will observe 1000 adults who visit a fever clinic, collecting information on their symptoms and test results. The goal is to understand the natural…

This study aims to see if measuring frailty (overall physical weakness and vulnerability) in older adults arriving at the emergency room with pneumonia can better predict who might die in the hospital or within 30 days. Researchers will observe 150 patients aged 65 and older to c…