COMMUNITY-ACQUIRED PNEUMONIA

This study tests whether a blood thinner (heparin) can help hospitalized adults with pneumonia avoid serious complications like needing a breathing machine or intensive care. About 4000 participants will receive either heparin or standard care. The goal is to see if heparin reduc…

This phase 3 trial compares amoxicillin alone to amoxicillin/clavulanate for treating community-acquired pneumonia in adults aged 65 and older who are hospitalized but not in intensive care. The goal is to see if the narrower antibiotic works just as well, which could reduce side…

This phase 3 trial tests whether adding trimodulin (a protein mixture from donated blood) to standard care can lower death rates in adults with severe community-acquired pneumonia who need a breathing machine. About 590 hospitalized patients will receive either trimodulin or a pl…

This study compares two ways of giving antibiotics to children with mild pneumonia: giving them right away versus waiting 72 hours to see if symptoms improve. The goal is to see if the 'watch and wait' approach can safely reduce unnecessary antibiotic use. About 2,000 children wi…

This study tests whether giving the antibiotic clarithromycin early, guided by a blood test (suPAR), can prevent pneumonia from worsening into sepsis. About 330 adults with community-acquired pneumonia will receive either clarithromycin or a placebo. The goal is to see if this ap…

This study tests whether the antiviral drug acyclovir helps people on breathing machines who have pneumonia and also have herpes simplex virus (HSV) in their lungs. About 616 adults in intensive care will be randomly assigned to receive acyclovir or no antiviral treatment. The go…

This study compares two common antibiotics, azithromycin and doxycycline, in adults hospitalized with community-acquired pneumonia who are also receiving a beta-lactam antibiotic. The goal is to see which combination helps patients leave the hospital sooner and reduces the need f…

This study tests whether awake patients with severe pneumonia can avoid being put on a breathing machine by lying face down (prone position) for up to 16 hours a day. Researchers will track 1078 adults in intensive care to see if this simple position change reduces the need for i…

This study tests whether a newer breathing machine (HVNI) works better than standard noninvasive ventilation (NIV) for adults with pneumonia who are having trouble breathing. About 100 participants will be randomly assigned to one of the two machines. The main goal is to see whic…

This study is collecting information from 20,000 adults with community-acquired pneumonia to understand how common it is, what puts people at risk, and how it interacts with other health conditions. Researchers will ask about symptoms, treatments, and hospital stays. No new treat…

This study looks at whether a simple frailty assessment can better predict serious outcomes like death in older adults with pneumonia. Researchers will follow 150 patients aged 65 and older in the emergency department, comparing the frailty scale to standard severity scores. The …

This study is looking at whether a blood test called D-dimer can help doctors understand how serious pneumonia is and how well patients might recover. Researchers will measure D-dimer levels in 50 adults admitted to the hospital with community-acquired pneumonia and compare them …

This study will follow 1,000 adults who come to fever clinics with a respiratory infection. Researchers will collect data on symptoms, lab tests, and chest scans at the start, then check in over time to see who develops pneumonia or other complications. The goal is to better unde…

This study is trying to understand why some people with severe flu in the ICU develop a dangerous fungal lung infection called aspergillosis. Researchers will compare the immune systems of 45 flu patients and non-flu pneumonia patients in the ICU. They hope to find differences in…