Could a 'Wait and See' approach cut antibiotic overuse in kids with pneumonia?

NCT ID NCT06986148

Recruiting now Disease control Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two ways of giving antibiotics to children with mild pneumonia: giving them right away versus waiting 72 hours to see if symptoms improve. The goal is to see if the 'watch and wait' approach can safely reduce unnecessary antibiotic use. About 2,000 children will take part, and their recovery and antibiotic use will be tracked for 14 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: antibiotics (amoxicillin or similar)
What this could lead to: If successful, this could show that a delayed antibiotic strategy is safe and effective for mild childhood pneumonia, reducing unnecessary antibiotic use and resistance.
What could go wrong: This is a behavioral strategy trial, not a new drug. The results depend on parents following instructions, and some children may still need immediate antibiotics. It is not a cure or major breakthrough.

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Conditions

The condition(s) this trial relates to.

Community-Acquired Pneumonia pneumonia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COMMUNITY-ACQUIRED PNEUMONIA COMMUNITY-ACQUIRED PNEUMONIA (CAP)

Contacts and locations

Locations

Ann & Robert H. Lurie Children's Hospital of Chicago
RECRUITING

Chicago, Illinois, 60611, United States
Children's Healthcare of Atlanta
RECRUITING

Atlanta, Georgia, 30329, United States
Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Primary Children's Hospital
RECRUITING

Salt Lake City, Utah, 84108, United States

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