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Could lying face down keep pneumonia patients off ventilators?

NCT ID NCT06966310

Symptom relief Sponsor: University Hospital, Tours Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether awake patients with severe pneumonia can avoid being put on a breathing machine by lying face down (prone position) for up to 16 hours a day. Researchers will track 1078 adults in intensive care to see if this simple position change reduces the need for intubation. The approach has shown promise in COVID-19 patients, and this trial aims to see if it works for other types of pneumonia.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
prone positioning (lying face down)
What this could lead to
If it works, this simple position change could reduce the need for breathing tubes and sedation in pneumonia patients.
What could go wrong
This is an early-stage study, and the benefit seen in COVID patients may not apply to other pneumonias. Lying face down can be uncomfortable.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 1,078 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Oct 2034

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients admitted to an intensive care unit or intermediate care unit * Suspicion of community acquired pneumonia (at least one of the 3 criteria): fever, cough, purulent expectoration * And abnormalities suggestive of pneumonia by chest X-ray or CT-scan * PaO2/FiO2 ratio \<300 mmHg (or equivalent SpO2/FiO2 i.e. \< 315 mmHg) under a minimum gas flow of 30 L/min. * Person affiliated to a French social security system or equivalent * Informed consent. Exclusion Criteria: * Positive SARS-COV2 test within the last 30 days * Indication for immediate intubation * Patients for whom a "do not intubate" decision has been made * Chest trauma or other contraindication to prone position * Patients with formal indication for non-invasive ventilation: exacerbation of chronic obstructive pulmonary disease, acute cardiogenic pulmonary oedema. * Pregnant or breastfeeding woman * Subjects who are under legal protection measure * More than 8h awake prone positioning prior to inclusion * More than 48h since intensive care unit or intermediate care unit admission.

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Conditions

The condition(s) this trial relates to.

Community-Acquired Pneumonia pneumonia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Community-acquired pneumonia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    38 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Intensive care, University Hospital, Amiens

    NOT_YET_RECRUITING

    Amiens, France

  • Intensive care, University Hospital, Angers

    NOT_YET_RECRUITING

    Angers, France

  • Intensive care, University Hospital, Argenteuil

    NOT_YET_RECRUITING

    Argenteuil, France

  • Intensive care, University Hospital, Belfort

    NOT_YET_RECRUITING

    Belfort, France

  • Intensive care, University Hospital, Besancon

    NOT_YET_RECRUITING

    Besançon, France

  • Intensive care, University Hospital, Bethune

    NOT_YET_RECRUITING

    Béthune, France

  • Intensive care, University Hospital, Blois

    NOT_YET_RECRUITING

    Blois, France

  • Intensive care, University Hospital, Bordeaux

    NOT_YET_RECRUITING

    Bordeaux, France

  • Intensive care, University Hospital, Bourg en Bresse

    NOT_YET_RECRUITING

    Bourg-en-Bresse, France

  • Intensive care, University Hospital, Bourges

    RECRUITING

    Bourges, France

  • Intensive care, University Hospital, Brest

    NOT_YET_RECRUITING

    Brest, France

  • Intensive care, University Hospital, Cochin

    NOT_YET_RECRUITING

    Paris, France

  • Intensive care, University Hospital, Colombes

    NOT_YET_RECRUITING

    Colombes, France

  • Intensive care, University Hospital, Dieppe

    NOT_YET_RECRUITING

    Dieppe, France

  • Intensive care, University Hospital, Dijon

    RECRUITING

    Dijon, France

  • Intensive care, University Hospital, Dreux

    NOT_YET_RECRUITING

    Dreux, France

  • Intensive care, University Hospital, Garches

    NOT_YET_RECRUITING

    Garche, France

  • Intensive care, University Hospital, Grenoble

    NOT_YET_RECRUITING

    Grenoble, France

  • Intensive care, University Hospital, La Roche sur Yon

    RECRUITING

    La Roche-sur-Yon, France

  • Intensive care, University Hospital, Le Mans

    RECRUITING

    Le Mans, France

  • Intensive care, University Hospital, Lens

    RECRUITING

    Lens, France

  • Intensive care, University Hospital, Lille

    NOT_YET_RECRUITING

    Lille, France

  • Intensive care, University Hospital, Lorient

    NOT_YET_RECRUITING

    Lorient, France

  • Intensive care, University Hospital, Lyon

    NOT_YET_RECRUITING

    Lyon, France

  • Intensive care, University Hospital, Lyon

    NOT_YET_RECRUITING

    Lyon, France

  • Intensive care, University Hospital, Morlaix

    RECRUITING

    Morlaix, France

  • Intensive care, University Hospital, Nantes

    RECRUITING

    Nantes, France

  • Intensive care, University Hospital, Nice

    NOT_YET_RECRUITING

    Nice, France

  • Intensive care, University Hospital, Nice

    NOT_YET_RECRUITING

    Nice, France

  • Intensive care, University Hospital, Orléans

    NOT_YET_RECRUITING

    Orléans, France

  • Intensive care, University Hospital, Poitiers

    RECRUITING

    Poitiers, France

  • Intensive care, University Hospital, Rouen

    NOT_YET_RECRUITING

    Rouen, France

  • Intensive care, University Hospital, Saint Brieuc

    RECRUITING

    Saint-Brieuc, France

  • Intensive care, University Hospital, Saint Nazaire

    RECRUITING

    Saint-Nazaire, France

  • Intensive care, University Hospital, Strasbourg

    NOT_YET_RECRUITING

    Strasbourg, France

  • Intensive care, University Hospital, Strasbourg

    NOT_YET_RECRUITING

    Strasbourg, France

  • Intensive care, University Hospital, Tenon

    NOT_YET_RECRUITING

    Paris, France

  • Intensive care, University Hospital, Tours

    RECRUITING

    Tours, France

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