University Hospital, Tours

This phase 3 trial compares two induction therapies—rabbit anti-thymocyte globulin (rATG) and basiliximab—in 244 sensitized kidney transplant recipients who do not have pre-existing donor-specific antibodies. The goal is to see which drug better prevents biopsy-proven acute rejec…

This Phase 3 trial tests whether adjusting the dose of bevacizumab based on each patient's drug levels can better control metastatic colorectal cancer. About 244 people will receive either standard or personalized dosing alongside chemotherapy. The main goal is to see if personal…

This trial tests whether adding rituximab to standard mycophenolate mofetil (MMF) therapy can improve lung function in people with severe lung scarring caused by systemic sclerosis. About 102 adults with this condition will receive either rituximab infusions plus MMF or placebo i…

This study follows 150 children aged 3 to 10 who have surgery to remove a hemivertebra (a wedge-shaped spinal bone that causes curvature). Researchers will track how well the spine stays corrected as the child grows and watch for complications like nerve problems or poor bone hea…

This study tests whether a dedicated care protocol for non-traumatic brain hemorrhage can reduce death and disability. Researchers will track 600 patients admitted to a French hospital, comparing outcomes before and after the protocol is introduced. The goal is to see if early, e…

This phase 3 trial is testing whether a blood pressure treatment plan that focuses on diuretics (water pills) works better than usual care for people with moderate to severe chronic kidney disease and uncontrolled high blood pressure. The study will include 720 participants and t…

This study tests whether a one-year program of remote exercise sessions and personalized diet advice can increase lean muscle mass in 100 adults with cystic fibrosis who are already taking the drug Trikafta. The program is designed to address new nutritional challenges, like weig…

This study tests whether a quick, non-invasive lung ultrasound can detect interstitial lung disease in people with rheumatoid arthritis. About 280 adults with RA and risk factors for lung disease will get an ultrasound, and results will be compared to standard chest CT scans. If …

This study is testing a new memory assessment tool called NEM (New evaluation of Episodic Memory) to see if it can better diagnose Alzheimer's disease in people with mild memory problems. Researchers will compare the NEM test with standard memory tests in 150 adults aged 50 and o…

This study aims to find out if proteins and fats in tears can be used to diagnose Alzheimer's disease. Researchers will collect tear samples from 90 participants (people with Alzheimer's and healthy volunteers) and compare the levels of certain biomarkers. If successful, this cou…

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can help prevent nausea caused by chemotherapy in breast cancer patients. Participants use the device twice daily around their chemo sessions, alongside standard anti-nausea medication. The g…

This study tests whether immersive virtual reality (VR) can train children with autism, aged 8 to 16, to better process multiple senses at once. Fifty participants will either receive VR training plus usual care or usual care alone. The goal is to see if VR practice helps them fe…

This study tests a program called SKILLS that focuses on common factors across different mental health conditions, rather than treating each disorder separately. About 60 adults with stable psychiatric diagnoses will take part. The goal is to see if this approach reduces symptoms…

This study tests a new high-tech device that uses eye-tracking to help patients in the intensive care unit (ICU) who are on breathing machines communicate with their caregivers. Many of these patients are awake but cannot speak due to a tube in their throat, which can be frustrat…

This study tests whether awake patients with severe pneumonia can avoid being put on a breathing machine by lying face down (prone position) for up to 16 hours a day. Researchers will track 1078 adults in intensive care to see if this simple position change reduces the need for i…

This study tests a type of talk therapy called dissociation-focused cognitive behavioral therapy (DF-CBT) for people with dissociative disorders, such as depersonalization or dissociative identity disorder. The goal is to see if it reduces symptoms like feeling detached from your…

This study looks at two common ways to start labor in pregnant women whose cervix hasn't softened enough after 24 hours of preparation. One method uses the hormone oxytocin, and the other uses a different hormone called prostaglandins. The goal is to see which approach leads to f…

This study tests whether serving food as easy-to-grip bites (finger food) helps elderly residents in care homes eat more, gain weight, and enjoy meals more. Thirty residents over 75 with weight loss or muscle loss will be randomly assigned to finger food or usual meals. The main …

This study tests whether giving a water pill (furosemide) and extra fluids during laser kidney stone surgery helps clear out tiny leftover fragments. About 374 adults who need this surgery will be randomly assigned to receive either the water pill plus fluids or standard care. Th…

This study tests whether using hypnosis during a screening colonoscopy helps people feel less anxious and in less pain, and whether it helps doctors complete the exam more fully. About 600 adults in France will be randomly assigned to receive either standard care or hypnosis duri…

This study is testing three different low doses of the blood thinner rivaroxaban in 10 adults on chronic hemodialysis. The goal is to see how the drug behaves in the body and how much it thins the blood, to find a dose that might lower bleeding risks. Participants will take each …

This study collects nasal cells from 100 adults during planned nose surgery. The cells are grown in the lab to create a realistic model for testing how well drugs are delivered and work. The goal is to build a cell collection that helps improve treatments for respiratory infectio…

This study looks at how the brain responds to sensory inputs like sight and sound in 200 children and adults, some with neurodevelopmental disorders (NDD) and some without. Participants will have EEG recordings during sensory tasks, complete behavioral tests, and practice percept…

This study is gathering information from 10,000 people who have had a spontaneous brain hemorrhage. Researchers will collect medical history, brain scans, and blood samples to better understand the condition and find clues that help predict recovery. The goal is to improve how do…

This study is testing a new, non-invasive ultrasound technique called Tissue Pulsatility Imaging (TPI) to measure tiny brain movements. Researchers will compare these measurements in 300 people with mild versus major cognitive disorders. The goal is to see if brain pulse patterns…

This study looks at how genes and body chemistry are linked in adults with phenylketonuria (PKU) who were treated early in life. Researchers will analyze blood and saliva samples from 149 participants to find patterns that may explain differences in health and thinking skills. No…

This study is testing whether a mathematical model using blood markers can predict how well rheumatoid arthritis patients will respond to a lower dose of the drug rituximab. Thirty adults with RA who already do well on standard-dose rituximab will switch to a lower dose. Research…

This study looks at specific immune cells (iNKT cells and monocytes) in people with lupus to see how certain receptors on these cells change when the disease is active versus stable. Researchers will collect extra blood samples from 50 lupus patients during routine visits. The go…

This study looks at how quickly the kidneys clear morphine in sickle cell patients having a painful crisis. Researchers will measure kidney function and morphine levels in 100 intensive care patients to see if higher doses are needed for effective pain relief. The goal is to pers…

This study looks at whether patients with severe breathing problems in the ICU should be allowed to eat or drink before they need a breathing tube. Currently, patients are often kept fasting to prevent food from entering the lungs, but this can cause discomfort and malnutrition. …

This study looks at bone marrow cells from children with acute leukemia and compares them to cells from children without blood diseases. The goal is to understand why some leukemias relapse or resist treatment. Researchers will measure how these cells use energy and handle stress…