University Hospital, Tours

This study tested whether adding the drug rituximab to standard care could stop acute rejection in kidney transplant patients. 40 adults who had a kidney transplant within the past year and showed signs of acute humoral rejection took part. The main goal was to see if rituximab c…

This study looked at whether adding methotrexate to adalimumab (a biologic drug) reduces the chance that the body makes antibodies against adalimumab in people with ankylosing spondylitis. About 110 adults with active disease who did not respond well to NSAIDs took part. The goal…

This study tested whether stable patients with a serious heart valve infection (endocarditis) could safely switch from intravenous (IV) antibiotics to oral amoxicillin pills. Over 300 adults participated. The goal was to see if the oral switch worked as well as continuing IV trea…

This study tested a cream containing sirolimus on rare skin growths called microcystic lymphatic malformations, which can ooze, bleed, and cause pain. 55 children and adults applied the cream to one area and a placebo cream to another for 12 weeks. The goal was to see if the siro…

This study tested whether patients with a serious heart valve infection (endocarditis) caused by staph bacteria could safely switch from intravenous (IV) antibiotics to oral pills after at least 10 days of IV treatment. The trial involved 162 adults with left-sided endocarditis. …

This study tested whether adding rituximab (a drug that calms certain immune cells) to standard mycophenolate mofetil treatment helps people with interstitial lung disease whose lungs are not responding to initial therapy. 122 adults with various ILD types received either rituxim…

This study tested the drug levetiracetam as the first treatment for seizures in 18 full-term newborns who had brain injury from lack of oxygen at birth. The goal was to find the right dose and check if it is safe and effective at reducing seizure activity on brain recordings. The…

This study tested whether people with HIV who have a low viral reservoir can safely switch from a three-drug regimen to a two-drug regimen (Truvada alone) while keeping the virus under control. The goal is to reduce long-term side effects and treatment costs. The trial involved 2…

This study compared 6 weeks versus 12 weeks of antibiotics for people with infected hip or knee prostheses who had surgery. Researchers wanted to see if the shorter course was just as effective at curing the infection without increasing relapse. The trial enrolled 410 adults acro…

This study tested the drug sirolimus (rapamycin) in 63 children aged 6 to 18 with large, complicated slow-flow vascular malformations (abnormal blood or lymph vessels). Each child had an observation period followed by 4 to 8 months of sirolimus treatment. The main goal was to see…

This study tested two ways to soften the cervix (cervical ripening) in women with prolonged pregnancies (41+ weeks). One method uses a drug called Propess (dinoprostone), the other uses a soft balloon device placed in the cervix. The goal was to see which method leads to fewer C-…

This study looked at two types of stents used in a procedure called TIPS, which creates a bypass in the liver to relieve complications of cirrhosis. One stent is covered with a special material to stay open longer but costs more; the other is a standard bare stent that is cheaper…

This study tested whether low-dose hydrocortisone, a common steroid, can help people with severe community-acquired pneumonia survive. Over 950 critically ill adults in intensive care received either the steroid or a placebo, alongside standard antibiotics and support. The goal w…

This study tested whether a real-time continuous glucose monitor could help detect and manage low blood sugar (hypoglycemia) in very low birth weight newborns. 48 infants were randomly assigned to either the continuous monitor or standard finger-stick testing for their first thre…

This study tested a sirolimus solution applied once daily to the tongue in 12 children and adults with mild to moderate lymphatic malformations. The goal was to see if it reduces severity of symptoms like oozing, bleeding, and pain over 12 weeks compared to no treatment. Research…

This study looked at whether the flu vaccine can reduce inflammation in people with stable coronary artery disease. Inflammation plays a key role in heart disease progression. The trial involved 47 adults aged 60 and older with stable heart disease, who received the flu vaccine e…

This pilot study tested whether a quick, 20-second ultrasound of the brain's blood vessels could help paramedics identify patients with a severe stroke caused by a large blocked artery. The study included 60 participants: healthy volunteers and suspected stroke patients. Research…

This study tests whether a device called Fibroscan can diagnose fatty liver disease (steatosis) without needing a biopsy. Researchers will measure liver stiffness and viscosity in 72 people, including healthy volunteers and patients with confirmed fatty liver. Results will be com…

This study tested a new high-frequency ultrasound probe to measure the depth of gum pockets, a key sign of periodontal disease. Researchers compared the ultrasound measurements to standard manual probing in 39 adults. The goal was to see if the ultrasound could accurately detect …

This study tested whether a special ultrasound using contrast dye can better diagnose placenta accreta, a condition where the placenta grows too deeply into the womb and can cause severe bleeding after birth. Researchers studied 80 pregnant women at high risk for this condition. …

This study tested whether a dye called iohexol can accurately measure kidney function in 100 ICU patients with unstable blood pressure. The goal was to see if this method could help detect acute kidney injury earlier than current tests. Researchers tracked how quickly the dye cle…

This study looked at whether chemicals in tears and eye surface cells can help diagnose amyotrophic lateral sclerosis (ALS) or predict how the disease will progress. Researchers collected tear samples and performed eye exams on 55 people with ALS and healthy controls. The goal wa…

This study tested whether a painless, non-radiation ultrasound of the chest can find early signs of lung scarring in people with scleroderma. Thirty patients without known lung disease on CT scans underwent thoracic ultrasound. The goal was to see how often ultrasound detects hid…

This study tested whether a special ultrasound with contrast dye (CEUS) can more accurately identify liver lesions than standard ultrasound or other imaging methods like CT and MRI. Researchers enrolled 878 participants with liver lesions found on standard ultrasound. The goal wa…

This study tested a two-step vaccine approach to prevent pneumococcal infections in 26 adults with diffuse large B-cell lymphoma who were receiving chemotherapy with rituximab. The vaccines, Prevenar and Pneumovax, were given in a prime-boost sequence to boost immune protection. …

This study tested whether taking a different antibiotic once a week, rotating between two drugs, could prevent urinary tract infections in people with neurogenic bladder. The 45 participants had at least four infections per year and used a catheter. The goal was to see if this ap…

This study tested whether taking a low-dose aspirin (160 mg) each night, starting before 16 weeks of pregnancy, could prevent pre-eclampsia and small babies in first-time mothers at high risk. Over 1,100 women with abnormal blood flow in the uterine artery were randomly assigned …

This study tested whether giving inhaled amikacin for three days could prevent pneumonia in 850 adults on breathing machines. Patients received either the drug or a placebo starting day 4 of ventilation. The goal was to see if the treatment reduced pneumonia cases up to day 28.

This study tested whether playing a gentle sound called 'pink noise' during deep sleep could strengthen memory in people with early Alzheimer's disease. Nineteen participants wore a special headband that delivered the noise on some nights and not on others. The goal was to see if…

This study looked at whether a specific breathing exercise (forced expiration while lying on the side of the surgery) can shorten the time children need a chest tube after lung surgery. The tube drains fluid that builds up after the operation. The study involved 140 children aged…

This study tested two ways of positioning patients with severe lung injury (ARDS) who are on ventilators and placed face-down (prone) to help breathing. The goal was to see if a 'swimmer' position—where the head is turned and one arm is bent—causes fewer severe pressure sores tha…

This study tested whether using magnetic pulses (rTMS) on the brain while people recall their traumatic memories can reduce PTSD symptoms. 39 adults with PTSD for at least 3 months received either 10Hz or 1Hz rTMS over 2 weeks. Researchers measured changes in PTSD severity using …

This study tested whether daily smell training over 12 weeks can improve mood and smell perception in 150 people with mild depressive symptoms or major depression. Participants practiced smelling different odors each day. Researchers measured changes in smell ability and emotiona…

This study tested whether a mild electrical brain stimulation technique called tDCS could improve the results of trauma-focused therapy for people with PTSD. 63 adults with chronic PTSD received either real tDCS or a fake version during therapy sessions. The goal was to see if th…

This study looked at whether giving the drug salbutamol (often used in asthma inhalers) through a nebulizer helps people with severe COPD who are having a flare-up and need a breathing machine. The trial included 43 adults and compared the drug to a placebo. The main goal was to …

This study looked at two different surgical methods for fixing hip fractures in people over 65. The goal was to see if a newer, less invasive method (MISS) causes less blood loss than the standard method (PHS). The study involved 108 participants and measured blood loss from the …

This study tested whether having conscious COVID-19 patients with breathing problems lie face down (prone position) while on high-flow oxygen could reduce the need for a breathing tube. Over 400 adults with COVID-19 pneumonia and mild to severe acute respiratory distress syndrome…

This study tested whether giving the breathing drug salbutamol through a high-flow nasal device works as well as the usual mask method for people with COPD. 25 adults with COPD took part. The goal was to see if the new method is not worse at improving lung function.

This study tested whether a one-hour dose of nitrous oxide (laughing gas) can quickly reduce depression symptoms in adults aged 60-90 whose depression hasn't improved with standard treatments. Sixty participants received either the gas or medical air, and their mood was tracked o…

This study tested whether a phone-based cognitive behavioral therapy program could help people with severe or morbid obesity reduce their food addiction. 154 participants received either 12 therapy sessions over 18 weeks or their usual care. The goal was to see if the therapy cou…

This study looked at how different ways of communicating (like talking in person vs. texting) change brain activity. Researchers used fMRI scans on 30 healthy young adults while they watched videos of different communication styles. The goal was to see if each style uses a differ…

This study looks at how mucus from the airways of people with bronchiectasis affects a new inhaled antibody treatment. Researchers will collect sputum samples from 30 adults with stable bronchiectasis and test how well the antibodies can reach and bind to bacteria in the lab. The…

This study looked at 600 babies born between 25 and 32 weeks of pregnancy. Each baby had an MRI scan around their original due date. Researchers then tested their thinking and problem-solving skills at age 5. The goal was to see if early brain images could predict later learning …

This study looked at how adults with autism spectrum disorder (ASD) and bipolar disorder (BD) experience and show emotions. Researchers measured things like heart rate, pupil size, and facial expressions in a lab, and also tracked emotions in daily life for a week. The goal was t…

This study tested whether screening high-risk patients for hidden peripheral arterial disease using a simple ankle blood pressure test is cost-effective. Over 600 patients were involved, and researchers compared different screening and counseling strategies. The goal was to see i…

This study followed 220 adults with phenylketonuria (PKU) in France to learn how the disease affects them later in life. Researchers looked for signs of cognitive decline, neurological problems, and how the disease impacts quality of life and social integration. No new treatment …

This study looked at 92 adults aged 55 and older with major depression to see if their brains had amyloid plaques, which are linked to Alzheimer's disease. Researchers used a special PET scan to measure plaque levels after 8 weeks of antidepressant treatment. The goal was to unde…

This study checks on 137 COVID-19 patients who were in the ICU and used awake prone positioning (lying on their belly) while on high-flow oxygen. Researchers want to see if this technique affects quality of life and survival more than two years later. Participants answer a phone …

This completed study followed 73 adults with bone or joint infections who needed antibiotics for at least 6 weeks. Researchers tracked how often side effects occurred, how severe they were, and whether they affected quality of life. The goal was to understand why some patients st…

This study tested whether holding regular, structured team meetings about ethics in the intensive care unit (ICU) helps nurses feel more included in decisions to limit or stop life support. Researchers measured changes in nurses' perception of the decision-making climate, their w…

This study analyzed blood samples from 33 men with advanced prostate cancer that no longer responds to hormone therapy. Researchers looked for tiny molecules called microRNAs that might predict whether a patient will resist chemotherapy or newer hormone drugs. The goal is to help…

This study looked at whether a 6-week mindfulness meditation program can change brain metabolism in areas linked to memory. Thirty female students were randomly assigned to either mindfulness training or muscle relaxation. Researchers used brain scans to measure chemicals like gl…

This study analyzed tear and eye fluid samples from 100 cataract surgery patients to find biomarkers that could predict dry eye disease after surgery. Researchers used advanced chemical analysis to look for clues in the eye's surface cells and inner fluid. The goal is to better u…

This study tested whether advanced MRI and ultrasound techniques can better measure muscle changes in people with rotator cuff tears. Three adults with a tear on one side and a healthy shoulder on the other took part. The goal was to see if these imaging tools could provide clear…

This completed study looked at blood and bone marrow samples from 102 healthy volunteers aged 18 to 85. Researchers measured levels of reactive oxygen species (a type of cell stress) and the activity of antioxidant genes. The goal was to see how age affects these factors, which c…

This completed study looked at how metabolism differs in people with ALS. Researchers took blood and skin samples from 9 patients to analyze molecules and genes. The goal was to better understand the disease, not to test a treatment.

This study looked at whether giving a written sheet to melanoma patients, to pass on to their close relatives, helps those relatives get a skin exam from a doctor. 420 patients and their family members took part. The goal was to see if the written reminder works better than just …

This study used special PET and MRI scans to look at brain activity in 27 men with autism, Fragile X syndrome, or no condition. The goal was to measure a brain chemical called glutamate, which helps nerve cells communicate. Researchers hope this will reveal how brain signaling di…

This study tested whether a systematic phone call from a medical student, supervised by a general practitioner, could reduce hospitalizations in patients with chronic heart or mental health conditions during the COVID-19 lockdown in France. Over 22,000 patients aged 70 and older …

This completed study looked at whether using ultrasound to measure the cervix can better predict the time from labor induction to delivery compared to the standard Bishop exam. Researchers followed 342 women with full-term, single pregnancies who had an unfavorable Bishop score. …

This study tested whether a special MRI technique called tractography can accurately map the brain's white matter tracts, which are like highways for nerve signals. Researchers scanned 134 older adults and compared the MRI images to brain tissue samples. The goal is to validate t…

This study looked at how people with current depression, those who have recovered from depression, and healthy people react physically to emotions. Researchers measured heart rate, breathing, skin sweat, and brain blood flow during emotional tasks. The goal was to understand diff…

This study tested a new ultrasound device to measure skin stiffness (fibrosis) in people with lymphedema or venous insufficiency. Researchers compared results from 130 participants, including healthy volunteers, to see if the device could detect differences in skin hardness. The …

This study looked at 12 men with benign enlarged prostate who had Greenlight laser surgery. Researchers used MRI and special ultrasound scans to measure the area of dead tissue created by the laser and tracked urinary symptoms for a year. The goal was to better understand how the…

This study aimed to find biological markers (biomarkers) in muscle, blood, and cells to help diagnose amyotrophic lateral sclerosis (ALS) earlier and understand the disease better. Researchers analyzed samples from 37 adults with ALS using advanced techniques to look at molecules…

This study looked at 69 adults with rheumatoid arthritis who were taking the drug adalimumab (Humira). Researchers measured drug levels in the blood over 6 months to see if they could predict who would respond well to treatment. The goal was to find a way to adjust doses early, i…

This study followed 150 children aged 2 to 12 who have a port wine stain on a leg. Researchers tracked how the stain changes as the child grows, and whether it leads to problems like blood vessel issues or bone growth differences. The goal was to learn more about the condition an…

This study looked at whether waiting to place an arterial catheter (a thin tube in an artery to monitor blood pressure) in critically ill patients with shock is as safe as placing it right away. Over 1,000 adults in intensive care were randomly assigned to either early or delayed…

This study looked at 40 adults—some with phenylketonuria (PKU) and some healthy—to see if PKU causes low-level inflammation in the body. Researchers measured inflammatory markers in blood samples. The goal was to better understand how PKU affects overall health, not to test a new…

This study aimed to find biological markers in blood, urine, and saliva that could help explain why up to 40% of people with depression do not respond to standard antidepressants. Researchers analyzed samples from 50 adults with major depression who had not taken antidepressants …

This study looked at how muscle energy works in 51 people with gastrointestinal cancer who were losing weight. The goal was to understand why cancer-related weight loss happens and find new ways to help. Researchers measured muscle cell energy use and fat storage, but this was an…

This study looked at two methods to help women who have not been screened for cervical cancer get tested. One group received a vaginal self-sampling kit in the mail, while the other was invited to visit their general practitioner. The goal was to see which approach leads more wom…

This study looked at 400 people aged 60-90 who had cataract surgery. They received either a white or yellow artificial lens. Researchers wanted to see if the color of the lens affected sleep time, sleep quality, and mood two months after surgery. The idea is that blue light filte…

This completed study looked at how muscle energy use differs in women with ovarian or endometrial cancer who are losing weight, depending on their body mass index (BMI). Researchers took blood samples, muscle biopsies, and fat tissue from 70 women during surgery. The goal was to …

This study looked at whether analyzing the fluid used to preserve kidneys on a LifePort® machine could help predict how well the kidney will work after transplant. Researchers measured chemicals in the fluid and compared them to early kidney function in 40 recipients. The goal is…

This study tested a new ultrasound method called Fast Cerebral Pulsatility Imaging (FCPI) to measure tiny brain movements in healthy adults aged 18 and older. Researchers aimed to see how these movements change from young adulthood to old age. The study involved 53 participants a…

This study looked at whether a specific gene (BDNF) influences how well people with major depression respond to antidepressants. Researchers compared the gene variations in 188 patients who either improved or did not improve after 3 to 6 weeks of treatment. The goal is to better …

This study looks at how nitrous oxide (laughing gas) changes brain activity in people with treatment-resistant depression. Researchers used ultrasound and MRI to measure brain blood flow and connectivity before, during, and after a one-hour dose of the gas. The goal is to find br…

This study looked at whether a routine urine culture before removing a ureteral stent (a small tube from kidney to bladder) helps prevent urinary infections. Over 2200 adults were split into two groups: one got the standard urine test, the other did not. Researchers then tracked …

This study looked at the specific symptoms of complex post-traumatic stress disorder (PTSD) compared to regular PTSD. Researchers used questionnaires to measure dissociation, emotional control, and trauma in 300 adults. The goal was to better understand and identify complex PTSD,…

This study looked at whether a device that delivers rapid puffs of air (intrapulmonary percussive ventilation) can help inhaled medication reach scarred lung areas in people with idiopathic pulmonary fibrosis (IPF). Nine participants inhaled a radioactive tracer with and without …