University Hospital, Tours

This study aims to find out if a specific job support program (called IPS) is more cost-effective than standard social worker support at helping unemployed adults with severe mental disorders get and keep regular jobs. It will follow 234 participants in France for 18 months, comp…

This study aims to see if providing extra oxygen directly into the nose during the critical moment of placing a breathing tube reduces the risk of severely low oxygen levels in ICU patients with breathing failure. It will compare a new method using a high-flow nasal oxygen device…

This study is testing whether a special brain ultrasound scan can help doctors decide which patients with suspected normal pressure hydrocephalus should receive shunt surgery. Researchers will measure brain pulsations in 110 patients before they undergo standard testing, then fol…

This study aims to find a faster way to diagnose ALS (amyotrophic lateral sclerosis) by looking for specific markers in blood platelets. Researchers will compare blood samples from 60 people recently diagnosed with ALS to those with other similar nerve diseases. The goal is to id…

This study is testing a less invasive way to get a tissue sample to diagnose interstitial lung disease (ILD). Researchers will compare a new ultrasound-guided biopsy done with local anesthesia to the standard surgical biopsy, which requires general anesthesia. The main goal is to…

This study is testing if a drug called propranolol, taken soon after a traumatic event, can prevent post-traumatic stress disorder (PTSD) from developing. It will involve 34 adult women who have recently experienced sexual violence. Participants will take either propranolol or a …

This study is testing a new tablet device that lets conscious patients who are on a ventilator in the intensive care unit (ICU) communicate using only their eye movements. Many patients in this situation cannot speak and describe the experience as a 'nightmare,' which increases a…

This study aims to understand how often ADHD and fibromyalgia occur together in the same person. Researchers will recruit 100 French adults with either condition to measure how common this overlap is. They will also analyze blood and urine samples to look for biological clues, li…

This study aims to understand why some lung cancer patients respond well to immunotherapy drugs while others do not. Researchers will collect and analyze sputum (mucus from the lungs) and blood samples from 50 patients before and during their standard immunotherapy treatment. The…

This study aims to create a detailed picture guide of the mouth using safe, non-invasive ultrasound. Researchers will scan the mouths of 100 adults during their regular dental check-ups to collect images of normal and abnormal tissues. The goal is to build a reference tool that c…

This study aims to understand why adults with PKU, a genetic metabolic disorder, experience the disease so differently from one another. Researchers will analyze DNA from saliva and blood samples from about 150 adults with PKU to look for links between their genes, their metaboli…

This study aims to gather detailed information from 10,000 adults who have suffered a spontaneous brain bleed (intracerebral hemorrhage). Researchers will collect clinical data, brain scans, and blood samples to better understand the disease, identify markers for outcomes, and se…