University Hospital, Tours

This study tests whether a 5-day course of inhaled amikacin can prevent ventilator-associated pneumonia in critically ill patients who already have a milder airway infection called tracheobronchitis. 250 adults on breathing machines will receive either the drug or a placebo. The …

This study tests whether wearing compression stockings alone can prevent repeat episodes of erysipelas (a bacterial skin infection) as well as the usual approach of antibiotics plus stockings. About 200 adults who have had at least two infections in the same leg will be randomly …

This study tests whether giving high-flow nasal oxygen during the intubation procedure can prevent severe drops in oxygen levels in ICU patients with acute respiratory failure. 500 participants will be randomly assigned to receive either the extra oxygen or usual care. The goal i…

This study aims to find specific markers in blood platelets that can help doctors diagnose ALS (Lou Gehrig's disease) more accurately and earlier. Researchers will compare 60 participants—30 with newly diagnosed ALS and 30 with other motor neuron diseases—to see if platelet tests…

This study tests whether an ultrasound-guided needle biopsy is a safe way to diagnose interstitial lung disease (ILD), a group of conditions that scar the lungs. Fifteen adults who need a tissue sample will first get the ultrasound-guided biopsy under local anesthesia, then have …

This study tests whether the blood pressure medication propranolol can prevent post-traumatic stress disorder (PTSD) in women who have experienced sexual violence. 34 women will receive either propranolol or a placebo within 72 hours of the assault, then take it for about three w…

This study tests whether adding aspirin to a standard anti-inflammatory gel can reduce pain from blood clots in children aged 6 to 17 with superficial venous malformations. The trial will compare aspirin plus gel against a placebo plus gel over 14 days. Only 34 children will take…

This study tests whether adding nitrous oxide (EMONO) to standard antidepressants can reduce depressive symptoms in nursing home residents aged 60 and older who have moderate to severe dementia. Participants receive either EMONO or medical air (placebo) via a face mask over sever…

This study tests whether dexmedetomidine, a sedative, can lower the chance of delirium (sudden confusion) in children who need a breathing machine in the ICU. About 266 children aged 1 month to 17 years will be randomly assigned to receive either dexmedetomidine or the standard d…

This study tests whether playing music through a sound shower in the ICU waiting room can reduce anxiety in family members. 224 adult relatives of intubated patients will be randomly assigned to wait with or without the music. Their anxiety levels will be measured using a standar…

This study will check how often people with ADHD also have fibromyalgia, and vice versa. Researchers will collect blood and urine samples from 100 adults to look for shared biological markers. The goal is to better understand why these two conditions often occur together.

This study tests whether a non-invasive brain ultrasound can predict which patients with suspected normal pressure hydrocephalus will improve after shunt surgery. Researchers will measure brain pulsatility before a lumbar puncture and again one year later. The goal is to see if t…

This study looks at whether common environmental chemicals like PFAS, bisphenol A, and pesticides are linked to childhood obesity. Researchers will measure levels of these chemicals in blood, urine, and hair samples from 80 children aged 6 to 15—half with obesity and half without…

This study aims to create a detailed atlas of ultrasound images of the mouth. Researchers will take ultrasound pictures of the inside and outside of the mouth in 100 adult dental patients. The goal is to better understand normal and diseased tissues, which could help dentists dia…

This study looks at sputum and blood samples from 50 adults with advanced non-small cell lung cancer who are starting immunotherapy. Researchers want to find immune cell changes that could predict which patients will respond well to treatment. The goal is to better understand the…

This study looks at a program called Individual Placement and Support (IPS) that helps people with severe mental disorders find regular jobs. It compares IPS to the usual way of getting help from social workers. The goal is to see if IPS is worth the extra cost by measuring how m…