Laughing gas tested as rapid depression treatment for dementia patients in nursing homes

NCT ID NCT06382389

Not yet recruiting Symptom relief Sponsor: University Hospital, Tours Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding nitrous oxide (EMONO) to standard antidepressants can reduce depressive symptoms in nursing home residents aged 60 and older who have moderate to severe dementia. Participants receive either EMONO or medical air (placebo) via a face mask over several weeks. The goal is to see if EMONO provides a faster and safer way to improve mood in this vulnerable group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

nitrous oxide (EMONO)

What this could lead to

If it works, this could offer a fast-acting, safer option to treat depression in older adults with dementia who live in nursing homes.

What could go wrong

This is a small, early-stage trial. The effect may be modest or no better than placebo, and side effects from nitrous oxide are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

cognitive disorder dementia Depression depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION NEUROCOGNITIVE DISORDERS