NEUROCOGNITIVE DISORDERS

This study is testing whether a special anesthesia plan focused on protecting the brain can reduce hidden strokes and thinking problems after heart surgery. Researchers will compare this new plan to standard care in over 900 older adults having planned heart surgery. The goal is …

This study is testing whether the drug donanemab is safe and effective at slowing the progression of early Alzheimer's disease. It will involve about 1,500 people who have mild memory problems and confirmed Alzheimer's-related brain changes. Participants will receive either the d…

This study is testing whether a 6-month lifestyle program can help improve memory, reasoning, and liver health in adults with Non-Alcoholic Fatty Liver Disease (NAFLD). Researchers are enrolling 45 participants aged 18-42 who will be randomly assigned to receive general health ad…

This study is testing a device that combines gentle magnetic brain stimulation with memory and thinking exercises. It aims to see if this non-invasive treatment can help slow or improve thinking problems in people with mild Alzheimer's disease. About 158 participants will receive…

This study is testing whether a computer can detect early signs of Alzheimer's disease by analyzing a person's speech patterns. Researchers will compare voice recordings from 100 adults (age 50+) with their existing medical test results. The goal is to create a simple voice test …

This study is testing whether a 6-month program focused on nutrition education, healthy cooking classes, and at-home brain exercises can help prevent cognitive decline in adults at higher risk for dementia. Researchers will enroll 120 adults aged 55-85 and randomly assign them to…

This study tests if involving family members in a proven hospital care program is better at preventing delirium (sudden, severe confusion) in older patients. It will compare the standard Hospital Elder Life Program (HELP) with a new version that trains and includes family caregiv…

This study is testing whether a sedative drug called dexmedetomidine can prevent long-term memory and thinking problems that sometimes occur after heart surgery. It will involve 2,400 patients aged 60 and older who are having planned heart surgery. Researchers will compare the dr…

This study is testing whether a fast-acting, oral calming medication (midazolam gel) can help elderly patients with moderate to severe dementia accept essential medical care, like bathing or wound dressing, when they are agitated and refusing it. It aims to see if this approach i…

This study aims to understand if speech therapy tailored for bilingual people can help those with primary progressive aphasia, a condition that causes worsening language problems. Researchers will test 60 bilingual participants to see if practicing in both their languages improve…

This study aims to understand if children born to mothers with type 1 diabetes are more likely to have differences in thinking skills, attention, or social behavior. Researchers are following up with 225 families from a previous pregnancy trial, asking parents to fill out questio…

This study aims to see if a small, contactless device placed in the bedroom can detect subtle changes in sleep patterns, walking speed, and daily activity in people with mild memory problems or early Alzheimer's disease. About 40 participants will have the device monitor them at …

This study is testing a new memory assessment tool designed to be more realistic to daily life. Researchers will compare how 60 adults aged 70 and older, with and without diagnosed memory disorders, perform on the test. The goal is to create a better tool for understanding memory…

This study aims to create and test a new questionnaire called LiCCoS, designed to help spot thinking and memory problems in adults with liver cirrhosis. Researchers will ask 230 participants with liver disease to complete the questionnaire and some standard memory tests to see if…

This study aims to see if a phone app can be used in a brain cancer clinic to measure patients' thinking skills, like memory and attention. It will also test if patients can report their quality of life electronically. The study is observational, meaning it watches and measures c…

This study aims to understand if a specific property of the carotid artery, called 'wall viscosity,' is linked to vascular dementia and Alzheimer's disease. Researchers will measure this artery stiffness in 140 participants over age 70 who have either type of dementia or memory c…