NEUROCOGNITIVE DISORDERS

This study tests a special anesthesia plan called NeuroFirst, designed to protect the brain during heart surgery. About 912 adults aged 60 and older will be randomly assigned to receive either NeuroFirst or standard care. The goal is to see if NeuroFirst reduces silent brain infa…

This study looks at whether a healthy diet and regular walking can improve memory and thinking in people with non-alcoholic fatty liver disease (NAFLD). 45 adults aged 18-42 will be split into three groups: one gets general health advice, another follows a Mediterranean diet, and…

This study tests a drug called donanemab in 1,500 people with early Alzheimer's disease. The goal is to see if it can slow down memory and thinking problems. Participants receive the drug or a placebo for up to 93 weeks, and researchers track changes in daily function and dementi…

This study tests whether a sedative called dexmedetomidine can prevent long-term memory and thinking problems that often occur after heart surgery. About 2,400 adults aged 60 and older having bypass or valve surgery will receive either dexmedetomidine or a placebo during their op…

This study is developing a computer algorithm that analyzes speech patterns to detect early Alzheimer's disease. Researchers will compare voice recordings from 100 adults aged 50 and older with existing brain and spinal fluid tests. If successful, this could replace painful lumba…

This study compares two programs designed to prevent delirium (sudden confusion) in older adults during hospital stays. About 1,900 patients aged 70 and older will take part, with one program involving family members as active helpers. The goal is to see which approach better red…

This study tests whether a program focused on healthy eating, exercise, and brain games can help prevent memory and thinking problems in older adults. Researchers will enroll 120 people aged 55 to 85 who are at higher risk for dementia. Participants will attend group sessions on …

This study tests if a liquid sedative (midazolam) can reduce resistance to care in elderly patients with moderate to severe dementia who refuse help. Researchers will give the medicine before care tasks and measure changes in agitation and cooperation. The trial involves 30 hospi…

This small pilot study tests whether a non-invasive brain stimulation technique called rTMS can reduce apathy in people with dementia or mild cognitive impairment. Apathy—a lack of interest or motivation—is common and disabling in these conditions. The study includes 10 participa…

This study tests a device called ATNC MDD-V1 that uses gentle magnetic pulses and brain exercises to improve thinking and memory in people with mild Alzheimer's. About 180 adults aged 60 to 85 who are already on stable Alzheimer's medication will receive either the real treatment…

This study looks at whether adding a physical activity education program to regular exercise helps people with mild memory or thinking problems more than exercise alone. About 34 participants will be followed for 6 months to see changes in activity level, thinking skills, and qua…

This study tests whether combining a gentle, non-invasive brain stimulation technique (called iTBS) with computer-based thinking exercises can help people with mild cognitive impairment (MCI). About 50 adults aged 60-85 will receive the same brain stimulation but be randomly assi…

This study aims to create and test a new questionnaire called LiCCoS for adults with liver cirrhosis. The goal is to help identify common thinking problems like forgetfulness and trouble focusing, which are often missed in regular checkups. About 230 participants will fill out th…

This study uses ultrasound to measure tiny brain movements in 300 people with mild or major cognitive disorders. Researchers want to see if these brain pulses differ between groups and change over time. The goal is to better understand how memory problems progress, not to test a …

This study is developing a practical memory test for adults aged 70 and older. Researchers will compare test results between people with memory disorders (like Alzheimer's) and healthy seniors. The goal is to create a better tool for assessing everyday memory skills.

This study is testing whether a smartphone app can reliably measure thinking and memory changes in 200 adults with brain tumors. Participants will use the app to complete memory, attention, and problem-solving tests, and report their quality of life. The goal is to see if these d…

This study looks at whether the viscosity (or 'stickiness') of the carotid artery wall differs between people with vascular dementia, Alzheimer's disease, and those without dementia. Researchers will measure artery wall behavior using ultrasound and a pressure sensor. The goal is…

This study follows up on children whose mothers had type 1 diabetes and took part in the CONCEPTT trial. Researchers will assess the children's thinking skills, behavior, and risk of autism using parent questionnaires. The goal is to understand how maternal diabetes during pregna…

This study looks at whether being bilingual helps people with primary progressive aphasia (PPA) respond better to speech therapy. Researchers will give tailored language treatment in both languages to 60 bilingual Spanish speakers and track their progress for a year. Another 30 p…

This study aims to find digital markers of brain energy changes in people with mild cognitive impairment or early Alzheimer's. Researchers will use passive home sensors to measure sleep, movement, and walking speed over 12 weeks. Participants take a daily supplement called nicoti…