New strategy aims to shield Seniors' brains during heart surgery

NCT ID NCT07048002

Recruiting now Disease control Sponsor: Chinese Academy of Medical Sciences, Fuwai Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a specific set of anesthesia targets, called NeuroFirst, can reduce silent brain injury and thinking problems in older adults having heart surgery. About 900 patients aged 60 and older will be randomly assigned to either the NeuroFirst approach or standard care. Researchers will use brain scans and thinking tests to compare outcomes up to one year after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: NeuroFirst target bundle (a set of anesthesia management goals including blood pressure, brain activity, oxygen levels, and temperature)
What this could lead to: If it works, this could point toward a standard way to protect the brain during heart surgery, reducing the risk of silent strokes and memory or thinking problems afterward.
What could go wrong: This is a single study testing a bundle of targets, not a new drug. It may not show a clear benefit, and the results might not apply to all heart surgery patients or hospitals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain infarction cognitive disorder MRI defined brain infarct

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC SURGERY NEUROCOGNITIVE DISORDERS NEUROPROTECTIVE SILENT BRAIN INFARCTION

Contacts and locations

Locations

Beijing Chaoyang Hospital，Capital Medical University
RECRUITING

Beijing, Beijing Municipality, 100020, China
Beijing Tiantan Hospital, Capital Medical University
RECRUITING

Beijing, Beijing Municipality, 100160, China
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College
RECRUITING

Beijing, Beijing Municipality, 100037, China
The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology
RECRUITING

Wuhan, Hubei, 430014, China
Xuanwu Hospital,Capital Medical University
RECRUITING

Beijing, Beijing Municipality, 100053, China

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