Calcium timing during bypass may cut need for heart drugs

NCT ID NCT03772990

Completed Disease control Sponsor: Meshalkin Research Institute of Pathology of Circulation Source: ClinicalTrials.gov ↗

First seen Jul 30, 2026 · Last updated Aug 05, 2026 · Updated 3 times

Summary

This trial tests whether giving calcium chloride as patients come off cardiopulmonary bypass reduces the need for drugs that support the heart and blood pressure. About 800 adults having valve or combined valve-and-bypass surgery will receive either calcium or a placebo. The goal is to see if a simple calcium dose can stabilize the heart during this critical transition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: calcium chloride
What this could lead to: If giving calcium at the right time reduces the need for strong heart medications after bypass, it could make cardiac surgery safer and recovery smoother.
What could go wrong: This is a single-center trial, and calcium can also cause dangerous side effects like heart rhythm problems or coronary spasm if levels get too high.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC SURGERY CARDIOPULMONARY BYPASS

Contacts and locations

Locations

B.V. Petrovsky Russian Scientific Surgery Center

Moscow, Russia
District clinical hospital

Khanty-Mansiysk, Russia
Federal Center for Cardiovascular Surgery

Astrakhan, Russia
Federal Center for Cardiovascular Surgery

Chelyabinsk, Russia
Federal Center for Cardiovascular Surgery

Penza, Russia
King Abdullah Medical City

Mecca, Saudi Arabia
M. Vladimirsky Moscow Regional Research Cinical Institute (MONIKI)

Moscow, Russia
Meshalkin Research Institute of Pathology of Circulation

Novosibirsk, 630055, Russia
Sh. Mohammed Bin Khalifa Bin Salman Al-Khalifa Cardiac Center

Manama, Bahrain
St Petersburg University Multifunctional Clinical Centre

Saint Petersburg, Russia
Tomsk National Research Medical Center

Tomsk, Russia

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