CARDIAC SURGERY

This study tests whether using a simple urine test to guide diuretic dosing can improve fluid removal after heart surgery. About 102 adults having heart surgery will be randomly assigned to standard care or a urine-sodium-guided approach. The goal is to see if this method safely …

This study tests a special anesthesia plan called NeuroFirst, designed to protect the brain during heart surgery. About 912 adults aged 60 and older will be randomly assigned to receive either NeuroFirst or standard care. The goal is to see if NeuroFirst reduces silent brain infa…

This study looks at whether giving iron through a vein (IV) after heart surgery can help people with iron-deficiency anemia recover faster and spend fewer days in the hospital. About 60 adults having planned heart surgery will receive either IV iron or a placebo shortly after sur…

This study looks at whether giving iron to anemic patients before heart surgery improves their long-term recovery. About 400 adults with iron deficiency anemia having major heart surgery will get either iron supplements or standard care. Researchers will track quality of life, sl…

This study tests whether cold-stored platelets work as well as standard room temperature-stored platelets to control bleeding in adults having heart surgery. About 150 participants will be randomly assigned to receive one type of platelet transfusion. The goal is to see if a larg…

This study tests new plastic tubes (cannulas) used to connect patients to a heart-lung machine during heart surgery. The goal is to check if they are safe and work as well as current tubes. About 80 adults having planned heart surgery will take part.

This study tests whether the inhaled anesthetic desflurane is better than the IV drug propofol at preventing major heart events like death, heart failure, or heart attack in adults undergoing coronary artery bypass surgery. About 3,560 participants will be randomly assigned to re…

This study tests whether a smartwatch can find hidden atrial fibrillation (an irregular heartbeat) in people who have had heart surgery. About 30% of patients develop this condition after surgery, but many have no symptoms and it can lead to strokes. The trial will compare standa…

This study tests an investigational drug called LSALT peptide to see if it can prevent or reduce acute kidney injury (AKI) in people having heart surgery with a heart-lung machine. About 240 adults scheduled for non-emergency heart surgery will receive either the drug or a placeb…

This study tests two different numbing techniques to manage pain after heart surgery. 50 adults having open-heart surgery will receive either one nerve block or a combination of two others. The goal is to find which method provides better pain relief and reduces the need for stro…

This study compares giving oral methadone before heart surgery versus intravenous methadone during anesthesia to see which better controls pain afterward. About 100 adults having elective heart surgery will take part at Mayo Clinic. The goal is to reduce the total amount of opioi…

This study tests whether a special nerve block (SPSIP block) can reduce pain and the need for strong painkillers after open-heart surgery. About 50 adults having planned heart surgery will receive either the block plus standard care or standard care alone. The main goal is to see…

This study tests two types of nerve blocks (TTPB and PIFB) to see which one provides better pain relief after open heart surgery. About 90 adults aged 40 to 60 will receive one of the blocks, and researchers will measure how much extra pain medicine they need and their pain level…

This study tests if giving a numbing medicine (ropivacaine) through chest tubes after heart surgery helps patients recover better and feel less pain. About 116 adults having planned heart surgery will take part. Half will get the medicine, half a placebo, and researchers will mea…

This study aims to find out how often people having heart surgery have trouble with their breathing tube (difficult airway) and what factors make it more likely. Researchers will watch 2000 adult heart surgery patients and use the information to create a prediction tool. The goal…

This study tests whether a smartphone-based platform using ERAS (Enhanced Recovery After Surgery) guidelines can reduce hospital stay after coronary artery bypass grafting. About 480 adults undergoing first-time bypass surgery at hospitals in São Paulo, Brazil, will participate. …

This study explores whether medical trainees (residents and fellows) can learn to use lung ultrasound to detect a collapsed lung (pneumothorax) after heart surgery. About 120 adults who recently had heart surgery and are having chest tubes removed will participate. After tube rem…

This study tracks 230 adults having planned heart surgery to see if drops in blood pressure during the operation lead to serious problems like confusion, kidney damage, stroke, or death within 30 days. Researchers will monitor blood pressure and use of medicines to raise it, then…

This study looks at whether blood backing up in the veins during heart surgery may increase the risk of delirium—a state of confusion and disorientation—after the operation. Researchers will monitor 120 adults undergoing planned heart surgery, using ultrasound to check for vein c…

This study tests a personalized breathing maneuver in children on ventilators—either after heart surgery or with severe lung failure. The goal is to see if adjusting the breathing machine settings can improve heart and lung function, reduce time on the ventilator, and lower the n…

This study looks at 160 adults having planned heart surgery to see if taking more than one blood pressure medication leads to more severe blood pressure drops right after anesthesia starts. Researchers will measure how low blood pressure goes and how long it stays low, and how mu…

This study compares two recovery plans for people having heart surgery. One plan aims to remove the breathing tube soon after surgery, while the other aims to remove it even earlier, right in the operating room. Researchers will track complications like lung problems, pain, and n…

This study looks at whether people who have had heart surgery can safely and effectively collect a swab from their own chest wound at home. About 40 adults will try it using a special instruction pack, with a researcher watching via video call. The goal is to see if this approach…

This study looks at why many older adults experience memory and thinking problems after heart surgery. Researchers will test 80 patients aged 60 and older with thinking assessments and blood tests before and after surgery. The goal is to find simple ways to predict or diagnose th…

This early-stage study tests a new tube (cannula) designed to keep blood flowing to the leg during heart surgery that uses a heart-lung machine. The device aims to reduce the risk of leg complications. Fifteen adults having planned heart surgery will be enrolled to check if the d…

This study aims to find out how often atrial fibrillation (an irregular heartbeat) happens after heart surgery and who is most at risk. About 150 adults having planned open-heart surgery will wear a small heart monitor patch to track their heart rhythm. The results will help doct…