Can a peptide shield kidneys during bypass surgery? new trial aims to find out

NCT ID NCT05879432

Recruiting now Disease control Sponsor: Arch Biopartners Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 trial tests whether the drug LSALT peptide can prevent or reduce acute kidney injury in 240 adults undergoing on-pump cardiac surgery. Participants receive either the drug or a placebo before surgery, and doctors monitor kidney function for a week. The goal is to see if the drug lowers the risk of kidney damage, which is a common complication after heart surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: LSALT peptide (Metablok)
What this could lead to: If successful, this could provide a new way to prevent kidney damage during heart surgery, reducing complications and recovery time.
What could go wrong: This is a Phase 2 trial with only 240 participants, so results may not apply to all patients. The drug may not reduce kidney injury more than a placebo, and side effects are still being studied.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease acute kidney injury prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE KIDNEY INJURY CARDIAC SURGERY

Contacts and locations

Locations

Cumming School of Medicine & Libin Cardiovascular Centre, University of Calgary
RECRUITING

Calgary, Alberta, T2N 4N1, Canada
Erciyes University, Faculty of Medicine - Semiha Kibar Organ Transplant & Dialysis Hospital
COMPLETED

Melikgazi, Kayseri, 38030, Turkey (Türkiye)
Gazi University
COMPLETED

Yenimahalle, Ankara, 06560, Turkey (Türkiye)
Kocaeli University, Faculty of Medicine Practices and Research Hospital
COMPLETED

İzmit, Kocaeli, 41001, Turkey (Türkiye)
Kosuyolu High Specialization Training and Research Hospital
COMPLETED

Kartal, Istanbul, 34865, Turkey (Türkiye)
Royal Columbian Hospital
RECRUITING

New Westminster, British Columbia, V3L 0A2, Canada
Sütçü İmam University, Faculty of Medicine
COMPLETED

Kahramanmaraş, Onikişubat, 46040, Turkey (Türkiye)
Unity Health Toronto, St. Michael's Hospital
RECRUITING

Toronto, Ontario, M5B 1W8, Canada
University Health Network, Toronto General Hospital
RECRUITING

Toronto, Ontario, M5G 1L7, Canada

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