CARDIAC SURGERY

This study compares two ways of deciding when heart surgery patients need a blood transfusion in the ICU. One uses a fixed blood count threshold, while the other also considers each patient's oxygen and lactate levels. The goal is to see if the personalized approach is as safe an…

About one in four older adults experiences confusion (delirium) after cardiac surgery, which can lead to longer hospital stays and higher risks. This pilot study tests whether using a brain-monitoring device to personalize blood pressure during surgery can help prevent delirium. …

This study tests a new technique called PWI-Box, which uses a device named GeminiS to isolate the pulmonary veins and treat atrial fibrillation (AF) during open-heart surgery. About 200 adults with AF who are already scheduled for heart surgery via sternotomy will take part. The …

This study tests whether customizing ventilator settings during heart bypass surgery can lower the risk of lung complications like pneumonia or respiratory failure. Researchers will compare a standard approach with one that adjusts settings based on lung mechanics. Eighty adults …

This study tests whether giving a single dose of intravenous iron the day after heart surgery can reduce the chance of long-term anemia. About 180 adults with low iron or anemia before surgery will be randomly assigned to receive either the iron treatment or a placebo. The main g…

This study tests if giving a simple amino acid infusion during heart surgery can prevent acute kidney injury, a common complication. Researchers will measure kidney damage markers in the urine of 130 adults before and after surgery. Half will receive standard care, and the other …

This study tests whether an anti-bloating patch can reduce stomach swelling after heart surgery. Stomach bloating is common after cardiac procedures and can slow recovery. The trial will compare standard care alone to standard care plus the patch in 150 adults undergoing elective…

This study tests whether foot massage or kinesio taping can help older adults (65+) move better and feel less afraid of movement after heart surgery. Sixty participants will receive one of the two treatments daily for a week. Researchers will measure mobility, pain, and fear of m…

This study tests whether combining breathing exercises with progressive muscle relaxation can reduce shortness of breath, anxiety, and delirium in patients recovering from heart surgery. 116 adults will be randomly assigned to either receive these techniques plus standard care, o…

This study compares two ultrasound-guided nerve blocks to manage pain after heart surgery through the breastbone. 80 adults will receive one of the two blocks plus standard care. The goal is to see which block reduces opioid use and pain better in the first 24 hours after surgery…

This study looks at whether listening to guided meditation audio can reduce stress and anxiety in people having open-heart surgery. About 72 adults will either receive meditation sessions or standard care. Researchers will measure stress hormones, blood sugar, and anxiety levels …

This study tests whether a special nerve block, called SPSIPB, can reduce pain and the need for strong painkillers after heart surgery. 120 adults having planned heart surgery will either get the block plus standard care, or standard care alone. The goal is to see if the block le…

This study will look at data from 918 adults who had planned heart surgery to find out why some develop atrial fibrillation, a common and serious irregular heartbeat. The researchers will also examine whether newer anesthesia methods, like a nerve block, might help protect agains…

This study will test whether artificial intelligence programs like ChatGPT, Gemini, and Copilot can interpret brain oxygen monitoring data as accurately as experienced clinicians during open heart surgery. Researchers will compare responses from AI tools and two doctors for 63 el…

This study looks at whether a new test called T-TAS can help predict bleeding after heart surgery. Researchers will take blood samples from 30 adults before, right after, and 24 hours after surgery. They will compare T-TAS results with standard tests and track how much bleeding a…

This study looks at whether placing patients face-down (prone) soon after heart surgery can improve how well the right side of the heart works. The idea is that this position helps open up collapsed parts of the lungs, making it easier for the heart to pump blood. About 80 adults…

This study will examine how the heart-lung machine used during cardiac surgery changes platelet function and metabolism. Researchers will take blood samples from 100 adult heart surgery patients at several time points. The goal is to link these platelet changes to post-surgery in…

This study looks at whether a special numbing shot (regional anesthesia) can reduce the chance of long-term pain after heart surgery compared to standard opioid painkillers. It will involve 180 adults having elective heart surgery. The study also tests a new questionnaire designe…

This study looks at whether using a special heart monitor (pulmonary artery catheter) during open heart surgery is necessary. About 1600 adults having heart surgery will be randomly assigned to either get the monitor or not. Researchers will compare how well they recover, focusin…

This study watches 210 older adults (60+) having heart surgery to see if the anesthesia drug remimazolam affects their thinking and memory afterward. Participants answer questionnaires about confusion and mental function. The goal is to learn, not to test a new treatment.

This study will test whether a noninvasive device can accurately measure how much oxygen is being delivered to the body during heart surgery. Researchers will compare readings from the new monitor to those from standard invasive catheters in 150 adult patients. If the new method …

This study looks at whether measuring antithrombin levels in the blood before heart surgery can predict if a patient will respond poorly to heparin, a blood thinner used during surgery. Researchers will collect one extra blood sample from 300 adults undergoing planned heart surge…

This study looks at whether a special breathing maneuver during heart surgery can improve heart and lung function in children with congenital heart disease. About 80 children will be randomly assigned to receive either the maneuver or standard care. The goal is to see if this app…

This study will enroll 400 older adults (over 60) having heart surgery to see if genetic differences affect how well methadone and oxycodone work and their side effects. Researchers will measure pain, nausea, breathing problems, and sedation. The goal is to personalize pain treat…

This study looks at whether making fibrinogen concentrate (a protein that helps blood clot) free for hospitals in Belgium changed how doctors manage bleeding during complex heart surgery. Researchers will compare transfusion rates and patient outcomes before and after the reimbur…

This study watches 100 heart surgery patients to learn why some develop serious gut issues. Researchers will track patients from hospital arrival to discharge, looking for early warning signs and risk factors. No new treatments are given—the goal is simply to better predict and d…

This study compares two ultrasound-guided techniques (Direct vs. Seldinger) for placing a small tube in the wrist artery of adults having heart surgery. It focuses on patients whose arteries are expected to be hard to access. The goal is to see which method works best on the firs…

This study tests whether using a video laryngoscope (McGRATH) to insert a heart ultrasound probe causes less throat injury than the standard method. About 100 adults having elective heart surgery will take part. The main goal is to see how often the throat gets bruised or cut dur…

This observational study will collect data from 15,000 heart surgery patients across many hospitals worldwide. Researchers will look at how anesthesia, heart-lung machines, and surgical techniques are used, and track patient outcomes like recovery time and complications. The goal…